Previous Network (to 2009)

Funding and Personnel
Network in Biotapestry
Data Sets

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NHLBI R33 Cluster Project HL089102, HL089123

Principal Investigators


Ellen Rothenberg              Hamid Bolouri

 

 


Computation

Constantin Georgescu
Bill Longabaugh

Data

E.-S. David-Fung
C. Franco
D. D. Scripture-Adams
T. Taghon
M. A. Yui
M. A. Zarnegar
R. Butler
K. J. Elihu


Click Here to View the Network Model Using the BioTapestry Interactive Network Viewer
from Georgescu et al., 2008

 

Evidence pages are also available directly below

( List of References )

 

GENES

Ablim1 Aff3 AI449175 Akap8
Bat2 Bcl11a Bcl11b Bcl2
Cd19 CD3 Cd3e Cd3g Cebpa Cebpb Cpa3 Csf2ra Ctdsp1
Ddx17 Ddx19b Dtx1 Dtx3l
Ebf1 Egr1 Egr2 Egr3 Elf4 Emr1 Epor Erg Ets1 Ets2
Fgfrl1 Fkbp5 Fli1 Fus
Gapdh Gata1 Gata2 Gata3 Gfi1 Gfi1b Gpr56 Grap
Hbb-b1 HEBalt Helz Hes1 Hoxb4 Huwe1
Id1 Id2 Id3 Ikzf1 Ikzf2 Ikzf3 Il2 Il2ra Il2rb Il7r Itgam
Kit
Lat Lck Ldb1 Lef1 Lmo2 Lzm-s2
Med26 Mitf Mll1 Mll2 Mpl Mpzl2 Mxd4 Myb
Nfe2 Notch1 Notch3 Nrarp
Pax5 Pou6f1 Prss16 Ptcra Ptpn7
Rab2a Rabgap1 Rag1 Ranbp1 Rbpj Runx1 Runx2 Runx3
Satb1 Senp2 Sfpi1 Sox13 Sox4 Spib Stat5b
Tal1 Tbx21 Tcf12 Tcf25 Tcf7 Tcfe2a Tcra-C Tcra Tmem131 Tpsb2 Trappc2l Trim44
Zap70 Zcchc11 Zfp109 Zfp27 Zfp30 Zfpm1

OTHER NODES

Delta
DN2, DN3 Stage Negative Regulator
DN3 Specific Regulator
E2A antagonized by SCL.Tal1 (net E2A)
E2A.E2A
E2A.HEB
E2A.SCL
EBF antagonized by Notch signaling (Net EBF)
Egr2+3
Ets-repr
GATA-1 antagonized by PU.1 (net GATA-1)
High-level GATA-3
High GATA3 modulated by Notch
IL-15.IL-2R signal
IL-7
IL-7.IL-7R
IL-7.IL-7R.STAT
IL7R.STAT signal
Inputs (Gfil, Bcl11b, TCF, Ets1.2)
Inputs (TCF, Ets, Sp1)
MAP kinase
Negative inputs
Net E protein activity
NK Cell Genes
NK Receptors
Notch-ICN
Notch-mod. GATA-3
Notch.CSL
Notch
Notch+MAPK
Other B-cell Different'n Genes
Other Eryth. Genes
Other Ets
Other Myeloid Genes
Other T-cell Differentiation Genes
Positive inputs
pre-TCR signal
Pre-TCR
PU.1 antagonized by GATA-1 (net PU.1)
PU.1 modulated by Notch.DL
PU.1 modulated by Notch
PU.1 transactivation
PU1 activity
Rearranged-TCR-Beta
Runx + corepressor
Runx+coactivator
Specification initiator

Data Sets:

Data on the short-term effects of removing fetal thymocytes from Notch-Delta interactions

Data compiled from two published studies, Franco et al. 2006 PNAS ("Chris data") and Taghon et al. 2007 Nat. Immunol. ("Mary data")

Data for effects of overexpression of GATA-3 wildtype and the partial agonist "GATA3-KRR" mutant in fetal thymocytes.

Data from Taghon et al. 2007 Nat. Immunol.

Gene Expression Pattern Comparison:

"LSK" (progenitor-like bone marrow cells) versus Pro-T, Pro-B, and pre-myeloid cells

Data from Tydell et al. 2007, The Journal of Immunology

Gene Expression Pattern Comparison:

"LSK" (progenitor-like bone marrow cells) versus Cells of five DN Stages

Data from Tydell et al. 2007, The Journal of Immunology

Gene Expression Pattern Comparison:

Intrathymic T Cell Precursors vs. Myeloid Progenitors

Data from Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology