| Upstream Node | Interaction Type | Target Node | Literature Evidence |
|---|
| bubble | REGULATES | pre-TCR signal | Bubble = assembly of full Pre-TCR signaling complex with kinases and adaptors |
| pre-TCR signal | REPRESSES | HES-1 | Taghon et al 2006 Immunity; Yui & Rothenberg 2004 J. Immunol. |
| pre-TCR signal | REPRESSES | SpiB | Taghon et al 2006 Immunity; Yui & Rothenberg 2004 J. Immunol. |
| pre-TCR signal | PROMOTES | Tcr-CAlpha | Taghon et al 2006 Immunity; Yui & Rothenberg 2004 J. Immunol. |
| pre-TCR signal | REPRESSES | HEBAlt | Taghon et al 2006 Immunity; Wang, D.et al.: Anderson, J Immunol. 2006 Jul 1;177(1):109-19; J. Immunol.; M. Yui and EVR, J Immunol. 2004 |
| pre-TCR signal | PROMOTES | Aiolos | Taghon et al 2006 Immunity |
| pre-TCR signal | REPRESSES | CD25 | Taghon et al 2006 Immunity |
| pre-TCR signal | REPRESSES | Deltex1 | Taghon et al 2006 Immunity |
| pre-TCR signal | PROMOTES | Egr1 | Carleton, M.et al.: Wiest J Immunol. 2002 Feb 15;168(4):1649-58. |
| pre-TCR signal | PROMOTES | Egr2 | Carleton, M.et al.: Wiest J Immunol. 2002 Feb 15;168(4):1649-58.; Taghon et al 2006 Immunity (note that most expression is in gamma delta T cells) |
| pre-TCR signal | PROMOTES | Egr3 | Carleton, M.et al.: Wiest J Immunol. 2002 Feb 15;168(4):1649-58.; Taghon et al 2006 Immunity (note that most expression is in gamma delta T cells) |
| pre-TCR signal | REPRESSES | Eva1 | C.C. Tydell et al 2007 J Immunol. |
| pre-TCR signal | PROMOTES | Id3 | Taghon et al 2006 Immunity |
| pre-TCR signal | REPRESSES | IL-7RAlpha | Taghon et al 2006 Immunity |
| pre-TCR signal | REPRESSES | Notch1 | Taghon et al 2006 Immunity |
| pre-TCR signal | REPRESSES | Notch3 | Taghon et al 2006 Immunity |
| pre-TCR signal | REPRESSES | Nrarp | Taghon et al 2006 Immunity |
| pre-TCR signal | REPRESSES | PTAlpha | Taghon et al 2006 Immunity |
| pre-TCR signal | REPRESSES | RAG-1 | Taghon et al 2006 Immunity |
| pre-TCR signal | REPRESSES | Bcl2 | Yui & Rothenberg 2004 J. Immunol.; Taghon et al 2006 Immunity (ab lineage only) |
| pre-TCR signal | REPRESSES | Erg | Anderson et al. 1999 Development; Anderson, M. K. Immunol Rev. 2006 Feb;209:191-211 |
| pre-TCR signal | PROMOTES | SATB1 | E.S.David-Fung, unpublished results |