| Upstream Node | Interaction Type | Target Node | Literature Evidence |
|---|---|---|---|
| PU.1 | PROMOTES | PU.1 antagonized by GATA-1 (net PU.1) | by definition |
| GATA-1 | REPRESSES | PU.1 antagonized by GATA-1 (net PU.1) | Nerlov, C.et al.: Graf Blood. 2000 Apr 15;95(8):2543-51 |
| PU.1 antagonized by GATA-1 (net PU.1) | PROMOTES | PU1 activity | by definition |