Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
Hes1	CD4	-4.19	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	CD4	-3.62	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Hes1	CD4_24-	-3.82	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Hes1	CD4_69-	-4.92	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Hes1	CD8	-5.37	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	CD8	-3.72	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Hes1	CD8_24-	-4.27	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Hes1	CD8_69-	-5.74	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Hes1	DN1	-0.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	DN1	-1.13	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Hes1	DN2	-0.82	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	DN2	-0.62	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	DN2	-0.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Hes1	DN2a	-0.92	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	DN2a	-1.02	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Hes1	DN3a	-0.19	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	DN3a	-0.05	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	DN3a	-0.64	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	DN3a	-0.41	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Hes1	DN3b	-1.15	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	DN3b	-0.89	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	DN3b	-1.44	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	DN3b	-1.25	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Hes1	DP	-3.82	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	DP	-4.41	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Hes1	DP69-	-5.12	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	DP69-	-2.52	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Hes1	GDT	-2.02	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Hes1	GDT	-2.2	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
HES.1	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
HES.1	LZ_noDL	-0.73	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
HES.1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HES.1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HES.1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HES.1	DL_PU1	0.05	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HES.1	DL_PU1	-0.14	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HES.1	DL_PU1	-0.32	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HES.1	noDL_LZ	-0.97	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HES.1	noDL_LZ	-0.67	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HES.1	noDL_LZ	-0.54	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HES.1	noDL_PU1	-1.72	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HES.1	noDL_PU1	-1.23	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HES.1	noDL_PU1	-1.22	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
.
Hes1	BM	-1.33	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Hes1	Mast	0.05	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Hes1	Fthymus	0.55	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
Hes1	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
Hes1	LZ_noDL	-0.66	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
Hes1	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Hes1	G3_DL	0.35	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Hes1	KRRm_DL	0.36	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Hes1	LZ_noDL	-0.66	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Hes1	G3_noDL	0.2	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Hes1	KRRm_noDL	0.25	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
Notch.CSL	PROMOTES	HES-1	Taghon et al 2005 Genes Dev; many other references
pre-TCR signal	REPRESSES	HES-1	Taghon et al 2006 Immunity; Yui & Rothenberg 2004 J. Immunol.
High-level GATA-3	PROMOTES	HES-1	Taghon, Yui, Rothenberg 2007 Nat. Immunol.; Anderson, M. K. et al 2002 Devel. Biol.
PU.1 modulated by Notch.DL	REPRESSES	HES-1	Franco et al. 2006 PNAS
Net E protein activity	PROMOTES	HES-1	Ikawa, T.et al.: Murre J Exp Med. 2006 May 15;203(5):1329-42; Schwartz, R.,et al.: Murre, Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9976-81.