Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
Cebpa	CD4	-4.68	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	CD4_24-	-3.8	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	CD4_69-	-5.62	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	CD8	-3.72	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	CD8_24-	-4.27	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	CD8_69-	-5.74	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	DN1	-1.66	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN1	-1.55	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN1	-2.55	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN1	-1.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	DN2	-3.82	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN2	-4.7	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	DN2a	-3.82	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN2a	-4	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN2a	-3.77	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN2a	-4.57	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	DN2b	-3.74	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN2b	-3.24	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	DN3a	-3.03	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN3a	-3.68	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN3a	-3.89	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN3a	-2.47	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN3a	-4.27	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN3a	-3.77	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	DN3b	-3.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN3b	-3.38	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DN3b	-4.8	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	DP	-4.66	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	DP69-	-4.19	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	DP69-	-3.89	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Cebpa	GDT	-4.01	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Cebpa	GDT	-4.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
C.EBPa	BM	1.19	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
C.EBPa	Mast	1.6	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
C.EBPa	Fthymus	0.48	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
C.EBPa	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
C.EBPa	LZ_noDL	0.53	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
C.EBPa	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
C.EBPa	LZ_noDL	0.06	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
C.EBPa	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
C.EBPa	G3_DL	-0.32	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
C.EBPa	KRRm_DL	-0.29	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
C.EBPa	LZ_noDL	0.06	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
C.EBPa	G3_noDL	-0.12	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
C.EBPa	KRRm_noDL	-0.02	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
C.EBPa	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
C.EBPa	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
C.EBPa	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
C.EBPa	DL_PU1	-0.21	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
C.EBPa	DL_PU1	0.63	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
C.EBPa	DL_PU1	-0.31	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
C.EBPa	noDL_LZ	0.5	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
C.EBPa	noDL_LZ	1.05	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
C.EBPa	noDL_LZ	0.05	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
C.EBPa	noDL_PU1	0.3	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
C.EBPa	noDL_PU1	0.91	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
C.EBPa	noDL_PU1	0.01	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
GATA-3	REPRESSES	C.EBPa	Taghon, Yui, Rothenberg 2007 Nat. Immunol.
Notch.CSL	REPRESSES	C.EBPa	weak early effect? Stronger indirect effect? (Franco et al. 2006 shows effect on purified Thy-1+ cells; not seen in crude fraction in Taghon et al 2007)
DN2, DN3 Stage Negative Regulator	REPRESSES	C.EBPa	Rothenberg, Moore, Yui 2008 Nat Rev Immunol
C.EBPa	PROMOTES	M-CSF-R	Petrovick, M.S.et al.: Tenen, Mol Cell Biol. 1998 Jul;18(7):3915-25
C.EBPa	PROMOTES	GM-CSF-R	Hohaus, S..et al.: Tenen, Mol Cell Biol. 1995 Oct;15(10):5830-45
C.EBPa	PROMOTES	Other Myeloid Genes	Friedman,A.D. Oncogene. 2007 Oct 15;26(47):6816-28