Effect of Key Gene Perturbations

SynonymPerturbationQPCR ExpressionRelative ToData From
Egr3LZ_DL0LZ,DLNotch-Delta interaction data (Franco et al. 2006 PNAS)
Egr3LZ_noDL-0.72LZ,DLNotch-Delta interaction data (Franco et al. 2006 PNAS)
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Egr3DL_LZ0DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr3DL_LZ0DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr3DL_LZ0DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr3DL_PU1-0.23DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr3DL_PU1-0.63DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr3DL_PU1-0.38DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr3noDL_LZ-0.68DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr3noDL_LZ-1.09DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr3noDL_LZ-0.38DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr3noDL_PU1-2.44DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr3noDL_PU1-2.36DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr3noDL_PU1-2.33DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream NodeInteraction TypeTarget NodeLiterature Evidence
PU1 activityREPRESSESEgr3Franco et al 2006 PNAS
pre-TCR signalPROMOTESEgr3Carleton, M.et al.: Wiest J Immunol. 2002 Feb 15;168(4):1649-58.; Taghon et al 2006 Immunity (note that most expression is in gamma delta T cells)
Egr3PROMOTESEgr2+3by definition