Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
pTa	CD4	-2.02	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	CD4	-2.48	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
pTa	CD4_24-	-2.57	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
pTa	CD4_69-	-4.32	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
pTa	CD8	-2.62	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	CD8	-3	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
pTa	CD8_24-	-4.26	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
pTa	CD8_69-	-4.92	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
preTa	DN1	-4.72	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
preTa	DN1	-4.64	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DN1	-3.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DN1	-3.72	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
pTa	DN2	-1.04	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DN2	-1.31	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DN2	-3.05	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
preTa	DN2a	-4.09	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
preTa	DN2a	-4.08	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DN2a	-4.4	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DN2a	-4.04	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
preTa	DN2b	-1.42	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
preTa	DN2b	-1.8	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
preTa	DN3a	0	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
preTa	DN3a	-0.17	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DN3a	0.34	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DN3a	-0.17	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DN3a	0.08	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DN3a	0.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
pTa	DN3b	-0.62	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DN3b	-0.7	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DN3b	-0.64	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DN3b	-0.6	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
pTa	DP	-0.8	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DP	-0.64	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
pTa	DP69-	-2.43	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	DP69-	-0.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
pTa	GDT	-2.15	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
pTa	GDT	-2.26	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
pTalpha	BM	-3.5	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
pTalpha	Mast	-3.63	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
pTalpha	Fthymus	0.31	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
pTalpha	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
pTalpha	LZ_noDL	-1.3	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
pTalpha	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
pTalpha	LZ_noDL	-1.7	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
pTalpha	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
pTalpha	G3_DL	-0.42	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
pTalpha	KRRm_DL	-0.19	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
pTalpha	LZ_noDL	-1.7	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
pTalpha	G3_noDL	-2.1	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
pTalpha	KRRm_noDL	-1.93	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
pTalpha	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
pTalpha	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
pTalpha	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
pTalpha	DL_PU1	0.07	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
pTalpha	DL_PU1	-0.14	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
pTalpha	DL_PU1	-0.12	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
pTalpha	noDL_LZ	-1.3	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
pTalpha	noDL_LZ	-1.39	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
pTalpha	noDL_LZ	-1.2	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
pTalpha	noDL_PU1	-1.39	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
pTalpha	noDL_PU1	-1.53	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
pTalpha	noDL_PU1	-1.18	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
.
pTalpha	Prmtv_LZ	-2.27	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	Prmtv_LZ	-0.81	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	Prmtv_PU1	-0.84	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	Prmtv_PU1	-1.35	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	ProT_PU1	-0.02	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	ProT_PU1	-0.08	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	ProT_PU1	-0.06	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	PreT_LZ	-0.13	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	PreT_LZ	-0.3	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	PreT_LZ	-0.01	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	PreT_PU1	-0.05	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	PreT_PU1	-0.45	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
pTalpha	PreT_PU1	-0.09	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
Notch.CSL	PROMOTES	PTAlpha	Reizis, B. & Leder Genes Dev. 2002 Feb 1;16(3):295-300; Franco et al. 2006 PNAS; Taghon et al 2007 Nat Immunol
pre-TCR signal	REPRESSES	PTAlpha	Taghon et al 2006 Immunity
Net E protein activity	PROMOTES	PTAlpha	Reizis, B. & Leder J Exp Med. 2001 Oct 1;194(7):979-90; Petersson K.et al.: Sigvardsson Eur J Immunol. 2002 Mar;32(3):911-20; Tremblay, M.et al.: Hoang, J Biol Chem. 2003 Apr 11;278(15):12680-7.
High-level GATA-3	REPRESSES	PTAlpha	Taghon, Yui, Rothenberg 2007 Nat. Immunol.; Anderson, M. K. et al 2002 Devel. Biol.
PTAlpha	PROMOTES	Pre-TCR	Structural component of pre-TCR