NORMAL UNPERTURBED IMMATURE THYMOCYTE GENE EXPRESSION
By set |
4 |
5 |
4 |
5 |
4 |
5 |
4 |
5 |
4 |
5 |
Gene
|
DN1.wt
|
DN1.wt
|
DN2.wt
|
DN2.wt
|
DN3a.wt
|
DN3a.wt
|
DN3b.wt
|
DN3b.wt
|
DN4.wt
|
DN4.wt
|
Aiolos
|
-2.09 |
-1.88 |
-3.72 |
-2.75 |
-1.98 |
-1.31 |
-1.45 |
-0.57 |
-0.71 |
-0.22 |
CD3e
|
-3.98 |
-4.25 |
-2.2 |
-2.17 |
-0.62 |
-0.59 |
-1.11 |
-1.15 |
-1.41 |
-1.4 |
Deltex1
|
-2.27 |
-2.36 |
-2.26 |
-2.24 |
-0.77 |
-0.77 |
-1.2 |
-1.62 |
-1.66 |
-2.87 |
E2A
|
-0.96 |
-0.38 |
-0.81 |
-0.48 |
-0.81 |
-0.66 |
-0.77 |
-0.46 |
-1.08 |
-0.34 |
Ets1
|
-1.11 |
-0.8 |
-0.51 |
-0.42 |
-0.01 |
-0.05 |
-0.14 |
0.06 |
-0.4 |
-0.02 |
Ets2
|
-2.65 |
-2.35 |
-2.58 |
-2.55 |
-1.44 |
-1.48 |
-1.8 |
-1.68 |
-1.88 |
-1.62 |
GATA3
|
-1.41 |
-1.33 |
-0.84 |
-0.99 |
-0.72 |
-0.84 |
-0.88 |
-0.74 |
-0.98 |
-1.31 |
"GATA3* (different assay, 1 yr later)"
|
-1.28 |
-1.26 |
-0.86 |
-0.78 |
-0.69 |
-0.82 |
-0.84 |
-0.54 |
-1.17 |
-1.01 |
Gfi1
|
-1.19 |
-1.13 |
-1.14 |
-1.13 |
-0.99 |
-1.03 |
-1.21 |
-1.1 |
-1.47 |
-1.14 |
Gfi1B
|
-1.23 |
-0.85 |
-1.39 |
-1.05 |
-2.21 |
-2.06 |
-2.49 |
-2.38 |
-2.82 |
-2.07 |
HEB
|
-1.13 |
-0.69 |
-0.79 |
-0.57 |
-0.24 |
-0.12 |
-0.51 |
-0.1 |
-0.69 |
-0.17 |
Helios
|
-0.94 |
-0.79 |
-0.97 |
-0.48 |
-1 |
-0.62 |
-1.3 |
-0.57 |
-1.04 |
-0.67 |
Id1
|
-3.18 |
-3.77 |
-2.95 |
-2.76 |
-2.46 |
-2.51 |
-3.14 |
-3.57 |
-2.93 |
-2.15 |
Id2
|
-2.5 |
-2.15 |
-2.65 |
-2.26 |
-2.28 |
-2.34 |
-2.89 |
-2.73 |
-3.31 |
-3.46 |
Id3
|
-3.5 |
-3.16 |
-2.93 |
-3.01 |
-2.2 |
-2.25 |
-1.51 |
-1.75 |
-1.86 |
-2.63 |
Ikaros
|
-0.61 |
-0.36 |
-0.85 |
-0.56 |
-0.93 |
-0.53 |
-1.12 |
-0.22 |
-0.72 |
-0.68 |
LEF-1
|
-2.33 |
-2 |
-1.71 |
-1.93 |
-0.17 |
0.07 |
0.33 |
0.04 |
0.3 |
-0.7 |
MEF (=Elf4)
|
-0.82 |
-0.4 |
-0.9 |
-0.61 |
-0.65 |
-0.57 |
-0.87 |
-0.6 |
-1.19 |
-0.56 |
Pou6f1
|
-3.63 |
-3.51 |
-3.12 |
-2.86 |
-1.63 |
-1.45 |
-1.91 |
-1.58 |
-1.83 |
-1.34 |
PU.1 (=Sfpi1)
|
-0.59 |
-0.3 |
-1.08 |
-0.75 |
-2.44 |
-2.03 |
-3.01 |
-2.69 |
-3.14 |
-3.78 |
Runx1
|
-0.27 |
-0.25 |
-0.03 |
-0.09 |
0.28 |
0.42 |
-0.16 |
-0.17 |
-0.62 |
-1.33 |
Runx2
|
-0.7 |
-0.57 |
-0.94 |
-0.88 |
-1.2 |
-1.08 |
-2.06 |
-1.64 |
-2.89 |
-2.27 |
Runx3
|
-0.37 |
-0.3 |
-0.44 |
-0.51 |
-0.88 |
-0.63 |
-0.96 |
-1.15 |
-1.32 |
-2.01 |
SpiB-1
|
-3.14 |
-3.51 |
-3.56 |
-3.3 |
-1.89 |
-1.98 |
-2.68 |
-3.95 |
-4.4 |
-3.35 |
SpiB-2
|
-4.07 |
-4.68 |
-2.9 |
-2.84 |
-1.21 |
-1.29 |
-2.33 |
-2.95 |
-3.08 |
-2.6 |
Tcf7.8
|
-0.47 |
-0.06 |
0.08 |
0.36 |
0.35 |
0.54 |
0.43 |
0.75 |
0.22 |
0.8 |
|
Averages of log transformed values
Gene |
DN1.avg |
DN2.avg |
DN3a.avg |
DN3b.avg |
DN4.avg |
Aiolos
|
-1.99 |
-3.23 |
-1.65 |
-1.01 |
-0.47 |
CD3e
|
-4.12 |
-2.19 |
-0.61 |
-1.13 |
-1.4 |
Deltex1
|
-2.32 |
-2.25 |
-0.77 |
-1.41 |
-2.26 |
E2A
|
-0.67 |
-0.65 |
-0.74 |
-0.62 |
-0.71 |
Ets1
|
-0.96 |
-0.46 |
-0.03 |
-0.04 |
-0.21 |
Ets2
|
-2.5 |
-2.56 |
-1.46 |
-1.74 |
-1.75 |
GATA3
|
-1.37 |
-0.91 |
-0.78 |
-0.81 |
-1.15 |
"GATA3* (different assay, 1 yr later)"
|
-1.27 |
-0.82 |
-0.76 |
-0.69 |
-1.09 |
Gfi1
|
-1.16 |
-1.14 |
-1.01 |
-1.16 |
-1.31 |
Gfi1B
|
-1.04 |
-1.22 |
-2.13 |
-2.43 |
-2.45 |
HEB
|
-0.91 |
-0.68 |
-0.18 |
-0.3 |
-0.43 |
Helios
|
-0.86 |
-0.72 |
-0.81 |
-0.93 |
-0.85 |
Id1
|
-3.48 |
-2.85 |
-2.49 |
-3.36 |
-2.54 |
Id2
|
-2.32 |
-2.46 |
-2.31 |
-2.81 |
-3.38 |
Id3
|
-3.33 |
-2.97 |
-2.23 |
-1.63 |
-2.24 |
Ikaros
|
-0.49 |
-0.71 |
-0.73 |
-0.67 |
-0.7 |
LEF-1
|
-2.17 |
-1.82 |
-0.05 |
0.19 |
-0.2 |
MEF (=Elf4)
|
-0.61 |
-0.75 |
-0.61 |
-0.73 |
-0.88 |
Pou6f1
|
-3.57 |
-2.99 |
-1.54 |
-1.75 |
-1.59 |
PU.1 (=Sfpi1)
|
-0.44 |
-0.92 |
-2.23 |
-2.85 |
-3.46 |
Runx1
|
-0.26 |
-0.06 |
0.35 |
-0.17 |
-0.97 |
Runx2
|
-0.63 |
-0.91 |
-1.14 |
-1.85 |
-2.58 |
Runx3
|
-0.34 |
-0.47 |
-0.76 |
-1.05 |
-1.67 |
SpiB-1
|
-3.33 |
-3.43 |
-1.93 |
-3.32 |
-3.87 |
SpiB-2
|
-4.38 |
-2.87 |
-1.25 |
-2.64 |
-2.84 |
Tcf7.8
|
-0.26 |
0.22 |
0.44 |
0.59 |
0.51 |
|
"Sets 4&5" adult DN thymocyte subsets, analyzed summer 2005
C57BL/6 mice, 4-6 wk old, sorted based on lack of CD4, 8, TCR, etc. and by c-kit, CD44, CD25, and CD27 expression (DN1-3) and by CD24, CD44, and CD25 expression (DN4)
All published in:
E.-S. David-Fung, M. A. Yui, M. Morales, H. Wang, T. Taghon, R. A. Diamond, and E. V. Rothenberg, Immunological Reviews 2006; 209:212-236
.
with the exception of Runx2 (not yet published)