| Upstream Node | Interaction Type | Target Node | Literature Evidence |
|---|
| PU.1 | REPRESSES | GATA-1 antagonized by PU.1 (net GATA-1) | bubble= net GATA-1 activity; Rekhtman, N. et al.: Skoultchi, Genes Dev. 1999 Jun 1;13(11):1398-411; Zhang, P.et al.: Tenen, Blood. 2000 Oct 15;96(8):2641-8. |
| GATA-1 | PROMOTES | GATA-1 antagonized by PU.1 (net GATA-1) | bubble= net GATA-1 activity |
| GATA-1 antagonized by PU.1 (net GATA-1) | PROMOTES | Gfi1B | bubble= net GATA-1 activity; Huang,D.Y., Kuo, & Chang, Nucleic Acids Res. 2005 Sep 21;33(16):5331-42. |
| GATA-1 antagonized by PU.1 (net GATA-1) | PROMOTES | Other Eryth. Genes | bubble= net GATA-1 activity |
| GATA-1 antagonized by PU.1 (net GATA-1) | PROMOTES | SCL.Tal-1 | bubble= net GATA-1 activity |