Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
Id3	CD4	-1.17	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	CD4	-1.39	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	CD4_24-	-1.38	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	CD4_69-	-1.06	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	CD8	-1.51	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	CD8	-1.13	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	CD8_24-	-1.25	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	CD8_69-	-1.17	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	DN1	-3.5	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Id3	DN1	-3.16	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Id3	DN1	-2.26	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN1	-3.85	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN1	-2.7	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN1	-2.47	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3-2	DN1	-3.68	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3-2	DN1	-4.64	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	DN2	-2.93	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Id3	DN2	-3.01	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Id3	DN2	-1.52	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN2	-1.55	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN2	-3.54	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	DN2a	-2.43	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN2a	-3.52	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN2a	-2.72	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN2a	-2.72	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3-2	DN2a	-3.19	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3-2	DN2a	-4.51	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	DN2b	-1.77	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN2b	-1.77	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3-2	DN2b	-2.07	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3-2	DN2b	-1.92	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	DN3a	-2.2	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Id3	DN3a	-2.25	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Id3	DN3a	-1.55	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN3a	-1.6	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN3a	-1.31	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN3a	-1.3	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN3a	-1.52	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN3a	-1.49	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3-2	DN3a	-1.58	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3-2	DN3a	-1.85	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	DN3b	-1.51	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Id3	DN3b	-1.75	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Id3	DN3b	-1	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN3b	-1.37	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN3b	-1.09	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DN3b	-1.36	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	DN4	-1.86	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Id3	DN4	-2.63	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
.
Id3	DP	-1.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DP	-1.23	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	DP69-	-1	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	DP69-	-1.06	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Id3	GDT	-0.92	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Id3	GDT	-0.82	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
Id3	BM	-1.18	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Id3	Mast	-2.22	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Id3	Fthymus	-0.26	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
Id3	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
Id3	LZ_noDL	0.32	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
Id3	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
Id3	LZ_noDL	0.39	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
Id3	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Id3	G3_DL	-0.21	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Id3	KRRm_DL	-0.33	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Id3	LZ_noDL	0.39	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Id3	G3_noDL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Id3	KRRm_noDL	0.05	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
Id3	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Id3	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Id3	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Id3	DL_PU1	-0.38	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Id3	DL_PU1	-0.24	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Id3	DL_PU1	-0.27	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Id3	noDL_LZ	0.23	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Id3	noDL_LZ	0.24	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Id3	noDL_LZ	0.49	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Id3	noDL_PU1	-0.24	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Id3	noDL_PU1	0.1	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Id3	noDL_PU1	-0.03	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
Egr1	PROMOTES	Id3	Bain, G.et al.: Murre Nat Immunol. 2001 Feb;2(2):165-71; Bettini, M.et al.: Kersh J Immunol. 2002 Aug 15;169(4):1713-20
PU1 activity	REPRESSES	Id3	Franco et al 2006 PNAS
Notch.CSL	REPRESSES	Id3	Taghon et al 2007 Nat Immunol; Franco et al 2006 PNAS
pre-TCR signal	PROMOTES	Id3	Taghon et al 2006 Immunity
DN3 Specific Regulator	PROMOTES	Id3	Rothenberg, Moore, Yui 2008 Nat Rev Immunol
High-level GATA-3	REPRESSES	Id3	Taghon, Yui, Rothenberg 2007 Nat. Immunol.
Id3	REPRESSES	Net E protein activity	by definition