Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
Runx1	CD4	-0.31	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	CD4	-0.58	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx1	CD4_24-	-0.4	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx1	CD4_69-	-0.74	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx1	CD8	-1.19	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	CD8	-1.02	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx1	CD8_24-	-1.21	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx1	CD8_69-	-1.27	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx1	DN1	-0.27	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx1	DN1	-0.25	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx1	DN1	0.11	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	DN1	-0.32	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx1	DN2	-0.03	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx1	DN2	-0.09	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx1	DN2	0.11	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	DN2	0.11	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	DN2	0.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx1	DN2a	0.08	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	DN2a	-0.07	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx1	DN3a	0.28	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx1	DN3a	0.42	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx1	DN3a	0.45	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	DN3a	0.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	DN3a	0.23	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	DN3a	0.51	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx1	DN3b	-0.16	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx1	DN3b	-0.17	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx1	DN3b	-0.13	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	DN3b	-0.18	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	DN3b	-0.09	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	DN3b	0.04	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx1	DN4	-0.62	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx1	DN4	-1.33	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
.
Runx1	DP	-0.23	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	DP	-0.35	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx1	DP69-	-0.8	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	DP69-	-0.42	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx1	GDT	-0.52	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx1	GDT	-0.54	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
Runx1	BM	-0.66	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Runx1	Mast	0.34	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Runx1	Fthymus	-0.12	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
Runx1	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
Runx1	LZ_noDL	-0.4	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
Runx1	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
Runx1	LZ_noDL	-0.51	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
Runx1	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Runx1	G3_DL	0.02	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Runx1	KRRm_DL	0.01	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Runx1	LZ_noDL	-0.51	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Runx1	G3_noDL	-0.42	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Runx1	KRRm_noDL	-0.36	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
Runx1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx1	DL_PU1	0.02	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx1	DL_PU1	-0.02	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx1	DL_PU1	0.02	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx1	noDL_LZ	-0.35	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx1	noDL_LZ	-0.53	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx1	noDL_LZ	-0.32	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx1	noDL_PU1	-0.29	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx1	noDL_PU1	-0.33	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx1	noDL_PU1	-0.13	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
.
Runx1	Prmtv_LZ	-0.27	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	Prmtv_LZ	-0.46	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	Prmtv_PU1	-0.19	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	Prmtv_PU1	-0.52	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	ProT_PU1	0.07	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	ProT_PU1	-0.25	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	ProT_PU1	0.13	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	PreT_LZ	-0.3	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	PreT_LZ	-0.61	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	PreT_LZ	-0.14	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	PreT_PU1	-0.32	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	PreT_PU1	-0.23	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx1	PreT_PU1	-0.01	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
Notch.CSL	PROMOTES	Runx1	Taghon et al 2007 Nat Immunol; Franco et al 2006 PNAS; cf. also Nakagawa,M.et al.: Chiba, Blood. 2006 Nov 15;108(10):3329-34.
Runx1	PROMOTES	Tcr-Beta	Wotton, D et al.: Owen, M. J. Mol Cell Biol. 1994 Jan;14(1):840-50; Kim, W.Y.et al.: Ito, EMBO J. 1999 Mar 15;18(6):1609-20
Runx1	PROMOTES	M-CSF-R	Petrovick, M.S.et al.: Tenen, Mol Cell Biol. 1998 Jul;18(7):3915-25
Runx1	REPRESSES	RAG-1	Yannoutsos, N.,et al.: Nussenzweig, Nat Immunol. 2004 Apr;5(4):443-50
Runx1	PROMOTES	Runx + corepressor	by definition
Runx1	PROMOTES	Runx+coactivator	by definition
Runx1	PROMOTES	Specification initiator	Guo, Y.et al.: Speck Blood. 2008 epub Apr 4. PMID: 18390836