Cell Type Specific Log10 QPCR Expression Values

SynonymCell TypeQPCR ExpressionNormalized ToData From
Notch3CD4-3.77bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3CD4-3.68bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3CD4_24--2.24bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3CD4_69--4.36bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3CD8-2.32bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3CD8-2.85bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3CD8_24--3.7bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3CD8_69--2.66bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3DN1-2.1bActinIntrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN1-2.01bActinIntrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN1-1.96bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN1-2.01bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3DN2-0.74bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN2-0.8bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN2-1.33bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3DN2a-1.22bActinIntrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN2a-1.47bActinIntrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN2a-1.28bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN2a-1.4bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3DN2b-0.92bActinIntrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN2b-0.82bActinIntrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3DN3a0.08bActinIntrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN3a-0.21bActinIntrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN3a0bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN3a0.04bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN3a-0.38bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN3a-0.28bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3DN3b-0.77bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN3b-0.92bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN3b-1.28bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DN3b-1.12bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3DP-1.55bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DP-1.48bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3DP69--2.05bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3DP69--1.34bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Notch3GDT-1.68bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Notch3GDT-1.92bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

SynonymPerturbationQPCR ExpressionRelative ToData From
Notch3BM-2.14ThymusGATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Notch3Mast-2.89ThymusGATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Notch3Fthymus-0.08ThymusGATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
Notch3LZ_DL0LZ,DLNotch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
Notch3LZ_noDL-1.05LZ,DLNotch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
Notch3LZ_DL0LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Notch3G3_DL0.04LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Notch3KRRm_DL0.19LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Notch3LZ_noDL-1.05LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Notch3G3_noDL -0.72LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Notch3KRRm_noDL-0.32LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
Notch3Prmtv_LZ-0.7Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3Prmtv_LZ-0.32Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3Prmtv_PU1-0.76Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3Prmtv_PU1-1.56Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3ProT_LZ0Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3ProT_LZ0Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3ProT_LZ0Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3ProT_PU1-0.16Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3ProT_PU1-0.33Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3ProT_PU1-0.17Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3PreT_LZ-1.04Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3PreT_LZ-0.51Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3PreT_LZ-0.39Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3PreT_PU1-0.45Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3PreT_PU1-0.24Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
Notch3PreT_PU1-0.64Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream NodeInteraction TypeTarget NodeLiterature Evidence
GATA-3PROMOTESNotch3Taghon, Yui, Rothenberg 2007 Nat. Immunol.; interpreted as physiological because Notch 3 expressed at DN3 stage when GATA-3 is at peak
Notch.CSLPROMOTESNotch3Taghon et al 2007 Nat Immunol
pre-TCR signalREPRESSESNotch3Taghon et al 2006 Immunity
DN3 Specific RegulatorPROMOTESNotch3Rothenberg, Moore, Yui 2008 Nat Rev Immunol
Net E protein activityPROMOTESNotch3Ikawa, T.et al.: Murre J Exp Med. 2006 May 15;203(5):1329-42.
Notch3PROMOTESNotchAssuming that Notch3 is here acting as Notch agonist