Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
Nrarp	BM	-0.71	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Nrarp	Mast	-0.51	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Nrarp	Fthymus	0.89	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
Nrarp	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
Nrarp	LZ_noDL	-0.45	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
Nrarp	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Nrarp	G3_DL	0.15	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Nrarp	KRRm_DL	0.24	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Nrarp	LZ_noDL	-0.45	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Nrarp	G3_noDL	-0.24	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Nrarp	KRRm_noDL	-0.06	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
pre-TCR signal	REPRESSES	Nrarp	Taghon et al 2006 Immunity
Notch.CSL	PROMOTES	Nrarp	Krebs, L.T.et al.: T. Gridley, 2001 Dev. Biol.; Pirot, P. et al. 2004 Biochem. Biophys. Research Commun.
Nrarp	REPRESSES	Notch-ICN	Yun, T.J. & Bevan, M. J. J Immunol. 2003 Jun 15;170(12):5834-41