Evidence for Interactions

Upstream NodeInteraction TypeTarget NodeLiterature Evidence
Notch-ICNREGULATESNotch.CSLby definition
CSLPROMOTESNotch.CSLby definition
Notch.CSLREPRESSESC.EBPaweak early effect? Stronger indirect effect? (Franco et al. 2006 shows effect on purified Thy-1+ cells; not seen in crude fraction in Taghon et al 2007)
Notch.CSLPROMOTESHEBAltWang, D.et al.: Anderson, J Immunol. 2006 Jul 1;177(1):109-19; Franco et al 2006 PNAS.
Notch.CSLPROMOTESCD25Taghon et al 2005 ; I. Maillardet al.: Pear, J Exp Med. 2006 Oct 2;203(10):2239-45.
Notch.CSLPROMOTESDeltex1Taghon et al 2005 Genes Dev; Franco et al. 2006 PNAS; Taghon et al 2007 Nat Immunol; many earlier references
Notch.CSLPROMOTESEts2Taghon et al 2007 Nat Immunol; Franco et al 2006 PNAS
Notch.CSLPROMOTESHES-1Taghon et al 2005 Genes Dev; many other references
Notch.CSLPROMOTESLEF-1Taghon et al 2007 Nat Immunol
Notch.CSLPROMOTESNotch1Taghon et al 2007 Nat Immunol
Notch.CSLPROMOTESNotch3Taghon et al 2007 Nat Immunol
Notch.CSLPROMOTESPTAlphaReizis, B. & Leder Genes Dev. 2002 Feb 1;16(3):295-300; Franco et al. 2006 PNAS; Taghon et al 2007 Nat Immunol
Notch.CSLPROMOTESRunx1Taghon et al 2007 Nat Immunol; Franco et al 2006 PNAS; cf. also Nakagawa,M.et al.: Chiba, Blood. 2006 Nov 15;108(10):3329-34.
Notch.CSLPROMOTESE2AFranco et al PNAS 2006; Taghon et al 2007 Nat Immunol; both quite weak
Notch.CSLREPRESSESId3Taghon et al 2007 Nat Immunol; Franco et al 2006 PNAS
Notch.CSLPROMOTESNrarpKrebs, L.T.et al.: T. Gridley, 2001 Dev. Biol.; Pirot, P. et al. 2004 Biochem. Biophys. Research Commun.
Notch.CSLREPRESSESNotch-mod. GATA-3by definition
Notch.CSLREPRESSESEBF antagonized by Notch signaling (Net EBF)Bubble = EBF activity;
Notch.CSLPROMOTESDN2, DN3 Stage Negative Regulatorconjectural; based on Notch requirement to reach DN2 stage
Notch.CSLPROMOTESDN3 Specific Regulatorconjectural; based on Notch requirement to reach DN3 stage
Notch.CSLREPRESSESEBFTaghon et al. 2005 Genes Dev; only demonstrated before EBF upregulation (see Smith, E.M.et al.: Sigvardsson, Blood. 2005 Sep 15;106(6):1995-2001 for alt. mechanism)
Notch.CSLPROMOTESGATA-3Taghon et al. 2005 Genes Dev
Notch.CSLPROMOTESNotch+MAPKby definition
Notch.CSLREPRESSESPU.1 modulated by Notch.DLby definition
Notch.CSLPROMOTESSpecification initiatorTydell et al. 2007 J. Immunol.
Notch.CSLPROMOTESHEBTaghon, Yui, Rothenberg 2007 Nat. Immunol.
Notch.CSLPROMOTESGfi1BTaghon, Yui, Rothenberg 2007 Nat. Immunol.
Notch.CSLREPRESSESId1Taghon, Yui, Rothenberg 2007 Nat. Immunol.
Notch.CSLPROMOTESLATTaghon, Yui, Rothenberg 2007 Nat. Immunol.
Notch.CSLPROMOTESLckTaghon, Yui, Rothenberg 2007 Nat. Immunol.
Notch.CSLPROMOTESCD3gTaghon, Yui, Rothenberg 2007 Nat. Immunol.
Notch.CSLPROMOTESCD3EpsilonTaghon, Yui, Rothenberg 2007 Nat. Immunol.
Notch.CSLPROMOTESRAG-1Taghon, Yui, Rothenberg 2007 Nat. Immunol.
Notch.CSLPROMOTESAiolosTaghon, Yui, Rothenberg 2007 Nat. Immunol.