Upstream Node | Interaction Type | Target Node | Literature Evidence |
---|
Notch-ICN | REGULATES | Notch.CSL | by definition |
CSL | PROMOTES | Notch.CSL | by definition |
Notch.CSL | REPRESSES | C.EBPa | weak early effect? Stronger indirect effect? (Franco et al. 2006 shows effect on purified Thy-1+ cells; not seen in crude fraction in Taghon et al 2007) |
Notch.CSL | PROMOTES | HEBAlt | Wang, D.et al.: Anderson, J Immunol. 2006 Jul 1;177(1):109-19; Franco et al 2006 PNAS. |
Notch.CSL | PROMOTES | CD25 | Taghon et al 2005 ; I. Maillardet al.: Pear, J Exp Med. 2006 Oct 2;203(10):2239-45. |
Notch.CSL | PROMOTES | Deltex1 | Taghon et al 2005 Genes Dev; Franco et al. 2006 PNAS; Taghon et al 2007 Nat Immunol; many earlier references |
Notch.CSL | PROMOTES | Ets2 | Taghon et al 2007 Nat Immunol; Franco et al 2006 PNAS |
Notch.CSL | PROMOTES | HES-1 | Taghon et al 2005 Genes Dev; many other references |
Notch.CSL | PROMOTES | LEF-1 | Taghon et al 2007 Nat Immunol |
Notch.CSL | PROMOTES | Notch1 | Taghon et al 2007 Nat Immunol |
Notch.CSL | PROMOTES | Notch3 | Taghon et al 2007 Nat Immunol |
Notch.CSL | PROMOTES | PTAlpha | Reizis, B. & Leder Genes Dev. 2002 Feb 1;16(3):295-300; Franco et al. 2006 PNAS; Taghon et al 2007 Nat Immunol |
Notch.CSL | PROMOTES | Runx1 | Taghon et al 2007 Nat Immunol; Franco et al 2006 PNAS; cf. also Nakagawa,M.et al.: Chiba, Blood. 2006 Nov 15;108(10):3329-34. |
Notch.CSL | PROMOTES | E2A | Franco et al PNAS 2006; Taghon et al 2007 Nat Immunol; both quite weak |
Notch.CSL | REPRESSES | Id3 | Taghon et al 2007 Nat Immunol; Franco et al 2006 PNAS |
Notch.CSL | PROMOTES | Nrarp | Krebs, L.T.et al.: T. Gridley, 2001 Dev. Biol.; Pirot, P. et al. 2004 Biochem. Biophys. Research Commun. |
Notch.CSL | REPRESSES | Notch-mod. GATA-3 | by definition |
Notch.CSL | REPRESSES | EBF antagonized by Notch signaling (Net EBF) | Bubble = EBF activity; |
Notch.CSL | PROMOTES | DN2, DN3 Stage Negative Regulator | conjectural; based on Notch requirement to reach DN2 stage |
Notch.CSL | PROMOTES | DN3 Specific Regulator | conjectural; based on Notch requirement to reach DN3 stage |
Notch.CSL | REPRESSES | EBF | Taghon et al. 2005 Genes Dev; only demonstrated before EBF upregulation (see Smith, E.M.et al.: Sigvardsson, Blood. 2005 Sep 15;106(6):1995-2001 for alt. mechanism) |
Notch.CSL | PROMOTES | GATA-3 | Taghon et al. 2005 Genes Dev |
Notch.CSL | PROMOTES | Notch+MAPK | by definition |
Notch.CSL | REPRESSES | PU.1 modulated by Notch.DL | by definition |
Notch.CSL | PROMOTES | Specification initiator | Tydell et al. 2007 J. Immunol. |
Notch.CSL | PROMOTES | HEB | Taghon, Yui, Rothenberg 2007 Nat. Immunol. |
Notch.CSL | PROMOTES | Gfi1B | Taghon, Yui, Rothenberg 2007 Nat. Immunol. |
Notch.CSL | REPRESSES | Id1 | Taghon, Yui, Rothenberg 2007 Nat. Immunol. |
Notch.CSL | PROMOTES | LAT | Taghon, Yui, Rothenberg 2007 Nat. Immunol. |
Notch.CSL | PROMOTES | Lck | Taghon, Yui, Rothenberg 2007 Nat. Immunol. |
Notch.CSL | PROMOTES | CD3g | Taghon, Yui, Rothenberg 2007 Nat. Immunol. |
Notch.CSL | PROMOTES | CD3Epsilon | Taghon, Yui, Rothenberg 2007 Nat. Immunol. |
Notch.CSL | PROMOTES | RAG-1 | Taghon, Yui, Rothenberg 2007 Nat. Immunol. |
Notch.CSL | PROMOTES | Aiolos | Taghon, Yui, Rothenberg 2007 Nat. Immunol. |