| Upstream Node | Interaction Type | Target Node | Literature Evidence |
|---|---|---|---|
| Rearranged-TCR-Beta | PROMOTES | Pre-TCR | Rate limiting component of pre-TCR |
| CD3 | PROMOTES | Pre-TCR | Integral component of pre-TCR |
| PTAlpha | PROMOTES | Pre-TCR | Structural component of pre-TCR |
| Pre-TCR | PROMOTES | bubble | Prequisite for signaling competence |