Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
Lef1	CD4	0.15	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	CD4	-0.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Lef1	CD4_24-	-0.89	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Lef1	CD4_69-	-0.6	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Lef1	CD8	-0.43	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	CD8	-0.54	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Lef1	CD8_24-	-1	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Lef1	CD8_69-	-0.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Lef	DN1	-2.21	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef	DN1	-2.92	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
LEF-1	DN1	-2.33	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
LEF-1	DN1	-2	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Lef1	DN1	-2.03	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	DN1	-3.68	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
LEF-1	DN2	-1.71	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
LEF-1	DN2	-1.93	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Lef1	DN2	-1.57	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	DN2	-1.7	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	DN2	-1.46	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Lef	DN2a	-2.36	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef	DN2a	-2.44	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	DN2a	-2.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	DN2a	-2.54	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Lef	DN2b	-1.33	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef	DN2b	-1.32	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Lef	DN3a	-0.28	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef	DN3a	-0.33	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
LEF-1	DN3a	-0.17	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
LEF-1	DN3a	0.07	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Lef1	DN3a	-0.06	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	DN3a	-0.55	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	DN3a	-0.29	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	DN3a	-0.09	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
LEF-1	DN3b	0.33	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
LEF-1	DN3b	0.04	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Lef1	DN3b	-0.21	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	DN3b	-0.34	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	DN3b	-0.26	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	DN3b	-0.02	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
LEF-1	DN4	0.3	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
LEF-1	DN4	-0.7	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
.
Lef1	DP	-0.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	DP	-0.32	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Lef1	DP69-	-0.46	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	DP69-	-0.48	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Lef1	GDT	-0.29	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Lef1	GDT	-0.19	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
LEF.1	BM	-2.12	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
LEF.1	Mast	-2.63	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
LEF.1	Fthymus	-0.16	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
LEF.1	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
LEF.1	LZ_noDL	-0.52	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
LEF.1	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
LEF.1	G3_DL	-0.35	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
LEF.1	KRRm_DL	-0.09	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
LEF.1	LZ_noDL	-0.52	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
LEF.1	G3_noDL	-0.89	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
LEF.1	KRRm_noDL	-0.88	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
Lef.1	Prmtv_LZ	0.58	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	Prmtv_LZ	-1.03	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	Prmtv_PU1	0.27	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	Prmtv_PU1	-1.46	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	ProT_PU1	0.66	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	ProT_PU1	-0.79	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	ProT_PU1	-0.55	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	PreT_LZ	0.74	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	PreT_LZ	-0.55	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	PreT_LZ	-0.06	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	PreT_PU1	0.63	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	PreT_PU1	-0.33	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Lef.1	PreT_PU1	-0.09	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
Notch.CSL	PROMOTES	LEF-1	Taghon et al 2007 Nat Immunol
DN3 Specific Regulator	PROMOTES	LEF-1	David-Fung et al 2006 Immunol. Rev.
High-level GATA-3	REPRESSES	LEF-1	Taghon, Yui, Rothenberg 2007 Nat. Immunol.