RELEVANT BACKGROUND PUBLICATIONS

  1. Georgescu C, Longabaugh W, Scripture-Adams D, David-Fung E, Yui M, Zarnegar M, and Bolouri H, and Rothenberg EV.  2008.  A gene regulatory network armature for T lymphocyte specification.  PNAS 105(51), 20100-20105.
  2. Chen F, Rowen L, Hood L, Rothenberg EV 2001. Differential transcriptional regulation of individual TCR V beta segments before gene rearrangement. J. Immunol. 166(3), 1771-1780.
  3. Anderson, M. K., Weiss, A. H., Hernandez-Hoyos, G., Dionne, C. J., and Rothenberg, E. V.  2002.  Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage.  Immunity 16, 285-296.
  4. Rothenberg, E. V. and Anderson, M. K.  2002.  Elements of transcription factor network design for T-lineage specification.  Devel. Biol. 246, 29-44.
  5. Anderson, M. K., Hernandez-Hoyos, G., Dionne, C. J., Arias, A. M., Chen, D., and Rothenberg, E. V.  2002.  Definition of regulatory network elements for T-cell development by perturbation analysis with PU.1 and GATA-3.  Devel. Biol. 246, 103-121.
  6. Rothenberg, E. V.  2002.  T lineage specification and commitment: a gene regulation perspective. Semin. Immunol. 14, 431-440.
  7. Rothenberg, E. V. and Dionne, C. J.  2002.  Lineage plasticity and commitment in T-cell development.  Immunol. Rev. 187, 96-115.
  8. Hernández-Hoyos, G., Anderson, M. K., Wang, C., Rothenberg, E. V., and Alberola-Ila, J.  2003.  GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation.  Immunity 19, 83-94.
  9. Warren, L. A. and Rothenberg, E. V.  2003.  Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors.  Curr. Opin. Immunol. 15, 166-175.
  10. Yui MA, Rothenberg EV. 2004. Deranged early T cell development in immunodeficient strains of nonobese diabetic mice. J. Immunol 173(9), 5381-5391
  11. Rothenberg, E. V. and Taghon, T.  2005.  Molecular genetics of T-cell development.  Annu. Rev. Immunol. 23, 601-649.
  12. Dionne, C. J., Tse, K. Y., Weiss, A. H., Franco, C. B., Wiest, D. L., Anderson, M. K., and Rothenberg, E. V.  2005.  Subversion of T lineage commitment by PU.1 in a clonal cell line system.  Devel. Biol. 280, 448-466.
  13. Taghon, T., David, E.-S., Zúñiga-Pflücker, J. C., and Rothenberg, E. V.  2005.  Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.  Genes Dev. 19, 965-978.
  14. David-Fung, E.-S., Yui, M. A., Morales, M., Wang, H., Taghon, T., Diamond, R. A., and Rothenberg, E. V.  2006.  Progression of regulatory gene expression states in fetal and adult pro-T cell development.  Immunol. Rev. 209, 212-236.
  15. Franco, C. B., Scripture-Adams, D. D., Proekt, I., Taghon, T., Weiss, A. H., Yui, M. A., Adams, S. L., Diamond, R. A., and Rothenberg, E. V.  2006.  Notch/Delta signaling constrains re-engineering of pro-T cells by PU.1.  Proc. Natl. Acad. Sci. USA 103, 11993-11998.
  16. Taghon T, Yui MA, Pant R, Diamond RA, Rothenberg EV. 2006. Developmental and Molecular Characterization of Emerging β- and γδ-Selected Pre-T Cells in the Adult Mouse Thymus Immunity. 24, 53-64.
  17. Wang D,Claus CL,Vaccarelli G., Braunstein M,Schmitt TM,Zuniga-Pflucker JC,Rothenberg EV, Anderson MK. 2006. The basic helix-loop-helix transcription factor HEBAlt is expressed in pro-T cells and enhances the generation of T cell precursors. J. Immunol. 177(1), 109-119.
  18. Rothenberg, E. V.  2007.  Cell lineage regulators in B and T cell development.  Nat. Immunol. 8, 441-444.
  19. Rothenberg, E. V. 2007.  Regulatory factors for initial T-lymphocyte lineage specification.  Curr. Opin. Hematol. 14, 322-329.
  20. Tydell, C. C., David-Fung, E.-S., Moore, J. E., Rowen, L., Taghon, T., and Rothenberg, E. V.  2007.  Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway.  J. Immunol. 179, 421-438.
  21. Rothenberg, E. V. 2007.  Negotiation of the T-lineage fate decision by transcription factor interplay and microenvironmental signals.  Immunity 26, 690-702.
  22. Taghon, T., Yui, M. A., and Rothenberg, E. V.  2007.  Mast cell lineage diversion of T lineage precursor cells by the essential T cell transcription factor GATA-3.  Nat. Immunol. 8, 845-855. 
  23. Rothenberg, E. V., Moore, J. E., and Yui, M. A.  2008.  Launching the T-lineage developmental programme.  Nat. Rev. Immunol. 8, 9-21.
  24. David-Fung, E.-S., Butler R, Buzi G, Yui, M. A., Diamond, R. A., Anderson M, Rowen L, and Rothenberg, E. V.   2009.  Transcription factor expression dynamics of early T-lymphocyte specification and commitment .  Developmental Biology 325(2), 444-467 .