Publications

  1. Del Real MM, Rothenberg EV. Architecture of a lymphomyeloid developmental switch controlled by PU.1, Notch and Gata3.  Development. 140(6), 1207-19
  2. Yui MA, Feng N, Zhang JA, Liaw CY, Rothenberg EV, Longmate JA. Loss of T cell progenitor checkpoint control underlies leukemia initiation in rag1-deficient nonobese diabetic mice.  J Immunol. 190(7), 3276-88
  3. Manesso E, Chickarmane V, Kueh HY, Rothenberg EV, Peterson C. Computational modelling of T-cell formation kinetics: output regulated by initial proliferation-linked deferral of developmental competence.  J R Soc Interface. 10(78), 20120774
  4. Zhang JA, Mortazavi A, Williams BA, Wold BJ, Rothenberg EV. Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity.  Cell. 149(2), 467-82
  5. Rothenberg EV. Transcriptional drivers of the T-cell lineage program.  Curr Opin Immunol. 24(2), 132-8
  6. Zarnegar MA, Rothenberg EV. Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer.  Oncogene. 31(43), 4647-54
  7. Kueh HY, Rothenberg EV. 2011. Regulatory gene network circuits underlying T-cell development from multipotent progenitors.  Wiley Interdiscip. Rev. Syst. Biol. Med. 4(1), 79-102
  8. Rothenberg EV, Zhang JA. 2011. T-Cell Identity and Epigenetic Memory.  Curr Top Microbiol Immunol. 356, 117-43
  9. Rothenberg EV. 2011.T cell lineage commitment: identity and renunciation.  J Immunol 186(12), 6649-55.
  10. Feng N, Vegh P, Rothenberg EV, Yui MA. 2011. Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice.  J Immunol 186(2), 826-37.
  11. Rothenberg EV. 2010. Lineage determination in the immune system.  Immunol Rev. 238(1), 5-11
  12. Rothenberg EV, Zhang J, Li L. 2010. Multilayered specification of the T-cell lineage fate.  Immunol Rev. 238(1), 150-68.
  13. Zarnegar MA, Chen J, Rothenberg EV. 2010. Cell-type-specific activation and repression of PU.1 by a complex of discrete, functionally specialized cis-regulatory elements.  Mol. Cell Biol. 30(20), 4922-39.
  14. Li L, Leid M, Rothenberg EV. 2010. An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b.  Science. 329(5987), 89-93
  15. Yui MA, Feng N, Rothenberg EV. 2010. Fine-scale staging of T cell lineage commitment in adult mouse thymus.  J Immunol. 185(1), 284-93
  16. David-Fung, E.-S., Butler R, Buzi G, Yui, M. A., Diamond, R. A., Anderson M, Rowen L, and Rothenberg, E. V.   2009.  Transcription factor expression dynamics of early T-lymphocyte specification and commitment .  Developmental Biology 325(2), 444-467 .
  17. Rothenberg EV, Scripture-Adams DD. 2008.  Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination.  Semin. Immunol. 20, 236-246 .
  18. Georgescu C, Longabaugh W, Scripture-Adams D, David-Fung E, Yui M, Zarnegar M, and Bolouri H, and Rothenberg EV.  2008.  A gene regulatory network armature for T lymphocyte specification.  PNAS 105(51), 20100-20105.
  19. Rothenberg, E. V., Moore, J. E., and Yui, M. A.  2008.  Launching the T-lineage developmental programme.  Nat. Rev. Immunol. 8, 9-21.
  20. Taghon, T., Yui, M. A., and Rothenberg, E. V.  2007.  Mast cell lineage diversion of T lineage precursor cells by the essential T cell transcription factor GATA-3.  Nat. Immunol. 8, 845-855. 
  21. Rothenberg, E. V. 2007.  Negotiation of the T-lineage fate decision by transcription factor interplay and microenvironmental signals.  Immunity 26, 690-702.
  22. Tydell, C. C., David-Fung, E.-S., Moore, J. E., Rowen, L., Taghon, T., and Rothenberg, E. V.  2007.  Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway.  J. Immunol. 179, 421-438.
  23. Rothenberg, E. V. 2007.  Regulatory factors for initial T-lymphocyte lineage specification.  Curr. Opin. Hematol. 14, 322-329.
  24. Rothenberg, E. V.  2007.  Cell lineage regulators in B and T cell development.  Nat. Immunol. 8, 441-444.
  25. Taghon T, Yui MA, Pant R, Diamond RA, Rothenberg EV. 2006. Developmental and molecular characterization of emerging β- and γδ-selected pre-T cells in the adult mouse thymus Immunity. 24, 53-64.
  26. Franco, C. B., Scripture-Adams, D. D., Proekt, I., Taghon, T., Weiss, A. H., Yui, M. A., Adams, S. L., Diamond, R. A., and Rothenberg, E. V.  2006.  Notch/Delta signaling constrains re-engineering of pro-T cells by PU.1.  Proc. Natl. Acad. Sci. USA 103, 11993-11998.
  27. David-Fung, E.-S., Yui, M. A., Morales, M., Wang, H., Taghon, T., Diamond, R. A., and Rothenberg, E. V.  2006.  Progression of regulatory gene expression states in fetal and adult pro-T cell development.  Immunol. Rev. 209, 212-236.
  28. Taghon, T., David, E.-S., Zúñiga-Pflücker, J. C., and Rothenberg, E. V.  2005.  Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.  Genes Dev. 19, 965-978.
  29. Dionne, C. J., Tse, K. Y., Weiss, A. H., Franco, C. B., Wiest, D. L., Anderson, M. K., and Rothenberg, E. V.  2005.  Subversion of T lineage commitment by PU.1 in a clonal cell line system.  Devel. Biol. 280, 448-466.
  30. Rothenberg, E. V. and Taghon, T.  2005.  Molecular genetics of T-cell development.  Annu. Rev. Immunol. 23, 601-649.
  31. Warren, L. A. and Rothenberg, E. V.  2003.  Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors.  Curr. Opin. Immunol. 15, 166-175.
  32. Hernández-Hoyos, G., Anderson, M. K., Wang, C., Rothenberg, E. V., and Alberola-Ila, J.  2003.  GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation.  Immunity 19, 83-94.
  33. Rothenberg, E. V. and Dionne, C. J.  2002.  Lineage plasticity and commitment in T-cell development.  Immunol. Rev. 187, 96-115.
  34. Rothenberg, E. V.  2002.  T lineage specification and commitment: a gene regulation perspective. Semin. Immunol. 14, 431-440.
  35. Anderson, M. K., Hernandez-Hoyos, G., Dionne, C. J., Arias, A. M., Chen, D., and Rothenberg, E. V.  2002.  Definition of regulatory network elements for T-cell development by perturbation analysis with PU.1 and GATA-3.  Devel. Biol. 246, 103-121.
  36. Rothenberg, E. V. and Anderson, M. K.  2002.  Elements of transcription factor network design for T-lineage specification.  Devel. Biol. 246, 29-44.
  37. Anderson, M. K., Weiss, A. H., Hernandez-Hoyos, G., Dionne, C. J., and Rothenberg, E. V.  2002.  Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage.  Immunity 16, 285-296.