| Upstream Node | Interaction Type | Target Node | Literature Evidence |
|---|
| PU1 activity | PROMOTES | PU.1 modulated by Notch.DL | by definition |
| Notch.CSL | REPRESSES | PU.1 modulated by Notch.DL | by definition |
| PU.1 modulated by Notch.DL | REPRESSES | Bcl11B | Franco et al PNAS 2006 |
| PU.1 modulated by Notch.DL | REPRESSES | c-Myb | Franco et al PNAS 2006; for PU.1 effect generally also Dionne et al. 2005 Devel. Biol. |
| PU.1 modulated by Notch.DL | REPRESSES | Ets1 | Franco et al PNAS 2006 |
| PU.1 modulated by Notch.DL | REPRESSES | FOG-1 | Franco et al PNAS 2006 |
| PU.1 modulated by Notch.DL | REPRESSES | Gfi1 | Franco et al PNAS 2006 |
| PU.1 modulated by Notch.DL | REPRESSES | HEB | Franco et al PNAS 2006 |
| PU.1 modulated by Notch.DL | PROMOTES | Id2 | Franco et al PNAS 2006; for PU.1 effect generally also Dionne et al. 2005 Devel. Biol. |
| PU.1 modulated by Notch.DL | REPRESSES | Ikaros | Franco et al PNAS 2006 |
| PU.1 modulated by Notch.DL | REPRESSES | LAT | Franco et al PNAS 2006 |
| PU.1 modulated by Notch.DL | REPRESSES | Lck | Franco et al PNAS 2006 |
| PU.1 modulated by Notch.DL | REPRESSES | RAG-1 | Franco et al PNAS 2006; for PU.1 effect generally also Dionne et al. 2005 Devel. Biol. |
| PU.1 modulated by Notch.DL | REPRESSES | TCF-1 | Franco et al PNAS 2006 |
| PU.1 modulated by Notch.DL | REPRESSES | Zap70 | Franco et al PNAS 2006 |
| PU.1 modulated by Notch.DL | REPRESSES | CD3g | Franco et al PNAS 2006 |
| PU.1 modulated by Notch.DL | REPRESSES | CD3Epsilon | Franco et al PNAS 2006 |
| PU.1 modulated by Notch.DL | REPRESSES | HES-1 | Franco et al. 2006 PNAS |