Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
cMyb	CD4	-1.42	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	CD4	-1.6	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
cMyb	CD4_24-	-1.14	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
cMyb	CD4_69-	-1.77	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
cMyb	CD8	-1.32	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	CD8	-2.7	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
cMyb	CD8_24-	-1.13	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
cMyb	CD8_69-	-1.82	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
cMyb	DN1	-0.36	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN1	-0.33	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN1	-0.41	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	DN1	-0.82	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	DN1	-0.74	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
.
cMyb	DN2	0.04	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN2	0.11	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN2	0.11	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN2	-0.34	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	DN2	-0.57	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	DN2	-0.39	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
.
cMyb	DN2a	0.04	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN2a	-0.09	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
cMyb	DN3a	0.18	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN3a	0.15	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN3a	-0.1	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN3a	0.08	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN3a	-0.36	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	DN3a	-0.96	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	DN3a	-0.23	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
.
cMyb	DN3b	-0.2	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN3b	-0.19	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN3b	-0.51	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN3b	-0.32	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DN3b	-0.85	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	DN3b	-0.55	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	DN3b	-0.7	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
.
cMyb	DN4	-0.96	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	DN4	-1.07	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	DN4	-1.11	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
.
cMyb	DP	-0.09	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DP	-0.13	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
cMyb	DP69-	-0.72	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	DP69-	-0.14	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
cMyb	GDT	-0.58	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
cMyb	GDT	-0.6	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
cMyb	LSK-	-0.89	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	LSK-	-0.89	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	LSK-	-0.96	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Myb	LSK-	-0.7	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Myb	LSK-	-0.8	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Myb	LSK-	-0.77	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
cMyb	LSK+	-0.7	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	LSK+	-0.8	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	LSK+	-0.77	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Myb	LSK+	-0.89	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Myb	LSK+	-0.89	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Myb	LSK+	-0.96	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
cMyb	PreM	-1.55	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	PreM	-1.34	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	PreM	-1.85	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Myb	PreM	-1.55	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Myb	PreM	-1.34	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Myb	PreM	-1.85	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
cMyb	ProB	-0.59	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	ProB	-0.72	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
cMyb	ProB	-0.85	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Myb	ProB	-0.59	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Myb	ProB	-0.72	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Myb	ProB	-0.85	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
Myb	ProT	-0.36	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Myb	ProT	-0.96	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Myb	ProT	-0.23	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
c.Myb	BM	-0.42	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
c.Myb	Mast	-0.41	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
c.Myb	Fthymus	0.25	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
c.Myb	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
c.Myb	LZ_noDL	-0.25	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
c.Myb	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
c.Myb	LZ_noDL	-0.27	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
c.Myb	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
c.Myb	G3_DL	0.05	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
c.Myb	KRRm_DL	0.12	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
c.Myb	LZ_noDL	-0.27	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
c.Myb	G3_noDL	-0.29	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
c.Myb	KRRm_noDL	-0.13	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
c.Myb	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
c.Myb	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
c.Myb	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
c.Myb	DL_PU1	-0.11	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
c.Myb	DL_PU1	-0.19	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
c.Myb	DL_PU1	-0.23	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
c.Myb	noDL_LZ	-0.23	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
c.Myb	noDL_LZ	-0.32	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
c.Myb	noDL_LZ	-0.2	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
c.Myb	noDL_PU1	-1.06	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
c.Myb	noDL_PU1	-0.82	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
c.Myb	noDL_PU1	-0.8	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
.
c.Myb	Prmtv_LZ	-0.13	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	Prmtv_LZ	-0.33	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	Prmtv_PU1	-0.94	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	Prmtv_PU1	-1.44	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	ProT_PU1	-0.45	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	ProT_PU1	-0.96	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	ProT_PU1	-0.64	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	PreT_LZ	-0.48	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	PreT_LZ	-0.57	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	PreT_LZ	-0.21	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	PreT_PU1	-0.7	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	PreT_PU1	-1.02	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
c.Myb	PreT_PU1	-0.6	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
PU.1 modulated by Notch.DL	REPRESSES	c-Myb	Franco et al PNAS 2006; for PU.1 effect generally also Dionne et al. 2005 Devel. Biol.
c-Myb	PROMOTES	RAG-1	Conjectural; based on Rag-1/Rag-2 coregulation and Myb inputs to Rag-2 per Wang QF, Lauring J, Schlissel MS Mol Cell Biol. 2000 Dec;20(24):9203-11; a different Myb complex, with Pax5 and LEF-1, controls Rag-2 in B cells per Jin,Z.X., et al.: Muraguchi, J Immunol. 2002 Oct 1;169(7):3783-92
c-Myb	PROMOTES	GATA-3	Maurice, D.et al.: Weston EMBO J. 2007 Aug 8;26(15):3629-40