Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
HEBalt	CD4	-5.09	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	CD4	-5.19	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBalt	CD4_24-	-3.47	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBalt	CD4_69-	-5.62	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBalt	CD8	-3.77	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	CD8	-3.72	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBalt	CD8_24-	-4.27	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBalt	CD8_69-	-5.08	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEB-alt	DN1	-2.96	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	DN1	-5.22	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	DN1	-4	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEBalt	DN1	-4.72	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN1	-4.64	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN1	-4.15	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN1	-3.64	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEB-alt	DN2	-1.27	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	DN2	-1.32	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	DN2	-1.29	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEBalt	DN2	-0.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN2	-0.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN2	-0.74	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBalt	DN2a	-1.05	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN2a	-0.92	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN2a	-0.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN2a	-1	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBalt	DN2b	-0.66	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN2b	-0.62	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEB-alt	DN3a	-1.07	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	DN3a	-1.14	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	DN3a	-1.22	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEBalt	DN3a	-0.57	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN3a	-0.68	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN3a	-0.43	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN3a	-0.7	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN3a	-0.55	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN3a	-0.6	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEB-alt	DN3b	-1.62	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	DN3b	-1.77	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	DN3b	-1.74	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEBalt	DN3b	-1.06	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN3b	-1.2	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN3b	-0.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DN3b	-0.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEB-alt	DN4	-2.33	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	DN4	-2.28	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	DN4	-2.15	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
.
HEBalt	DP	-4.89	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DP	-3.89	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBalt	DP69-	-5	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	DP69-	-3.39	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBalt	GDT	-2.58	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBalt	GDT	-2.54	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEB-alt	LSK-	-2.96	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	LSK-	-2.42	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	LSK-	-2.72	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEBalt	LSK-	-3.85	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBalt	LSK-	-3.4	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBalt	LSK-	-3.4	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
HEB-alt	LSK+	-3.17	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	LSK+	-2.96	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	LSK+	-2.8	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEBalt	LSK+	-3.08	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBalt	LSK+	-3.11	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBalt	LSK+	-3.22	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
HEB-alt	PreM	-2.82	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	PreM	-3.64	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	PreM	-3.32	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEBalt	PreM	-3.43	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBalt	PreM	-4.22	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBalt	PreM	-3.62	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
HEB-alt	ProB	-1.89	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	ProB	-1.96	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEB-alt	ProB	-2.47	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
HEBalt	ProB	-2.27	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBalt	ProB	-2.39	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBalt	ProB	-2.85	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
HEBalt	ProT	-1.77	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBalt	ProT	-1.34	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBalt	ProT	-1.2	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
HEBAlt	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
HEBAlt	LZ_noDL	-1	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
HEBAlt	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBAlt	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBAlt	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBAlt	DL_PU1	-0.89	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBAlt	DL_PU1	-0.18	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBAlt	DL_PU1	-0.38	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBAlt	noDL_LZ	-0.97	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBAlt	noDL_LZ	-1.08	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBAlt	noDL_LZ	-0.96	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBAlt	noDL_PU1	-1.56	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBAlt	noDL_PU1	-1.8	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBAlt	noDL_PU1	-1.15	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
.
HEBAlt	Prmtv_LZ	-0.05	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	Prmtv_LZ	-0.73	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	Prmtv_PU1	-1.11	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	Prmtv_PU1	-0.65	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	ProT_PU1	-0.7	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	ProT_PU1	-0.25	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	ProT_PU1	-1.2	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	PreT_LZ	-0.64	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	PreT_LZ	-0.16	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	PreT_LZ	-0.42	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	PreT_PU1	-1.31	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	PreT_PU1	-0.28	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBAlt	PreT_PU1	-0.4	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
Notch.CSL	PROMOTES	HEBAlt	Wang, D.et al.: Anderson, J Immunol. 2006 Jul 1;177(1):109-19; Franco et al 2006 PNAS.
PU1 activity	REPRESSES	HEBAlt	Franco et al 2006 PNAS, Dionne et al 2005 Devel. Biol.
Specification initiator	PROMOTES	HEBAlt	C.C. Tydell et al 2007 J Immunol.
pre-TCR signal	REPRESSES	HEBAlt	Taghon et al 2006 Immunity; Wang, D.et al.: Anderson, J Immunol. 2006 Jul 1;177(1):109-19; J. Immunol.; M. Yui and EVR, J Immunol. 2004
Net E protein activity	PROMOTES	HEBAlt	Wang, D.et al.: Anderson, J Immunol. 2006 Jul 1;177(1):109-19.
HEBAlt	PROMOTES	Net E protein activity	Conjectural; D. Wang et al. 2006 J. Immunol.
HEBAlt	PROMOTES	E2A.HEB	Conjectural; from Wang, D.et al.: Anderson, J Immunol. 2006 Jul 1;177(1):109-19.