Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
Egr1	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
Egr1	LZ_noDL	0.15	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
Egr1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr1	DL_PU1	-0.39	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr1	DL_PU1	0.31	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr1	DL_PU1	0.58	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr1	noDL_LZ	-0.26	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr1	noDL_LZ	0.42	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr1	noDL_LZ	0.28	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr1	noDL_PU1	-0.4	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr1	noDL_PU1	0.39	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Egr1	noDL_PU1	0.34	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
pre-TCR signal	PROMOTES	Egr1	Carleton, M.et al.: Wiest J Immunol. 2002 Feb 15;168(4):1649-58.
Egr1	PROMOTES	Id3	Bain, G.et al.: Murre Nat Immunol. 2001 Feb;2(2):165-71; Bettini, M.et al.: Kersh J Immunol. 2002 Aug 15;169(4):1713-20