Evidence for Interactions

Upstream NodeInteraction TypeTarget NodeLiterature Evidence
Egr2+3REPRESSESDN3 Specific RegulatorCarleton, M.et al.: Wiest J Immunol. 2002 Feb 15;168(4):1649-58.
Notch.CSLPROMOTESDN3 Specific Regulatorconjectural; based on Notch requirement to reach DN3 stage
DN3 Specific RegulatorPROMOTESEva1Tydell et al. 2007 J. Immunol.
DN3 Specific RegulatorPROMOTESNotch1Taghon et al. 2006 Immunity
DN3 Specific RegulatorPROMOTESSpiBDavid-Fung et al 2006 Immunol. Rev.; Taghon et al. 2006 Immunity; Lefebvre, J.M.et al.: Wiest, J Immunol. 2005 May 15;174(10):6184-94; Yui & Rothenberg 2004 J. Immunol.
DN3 Specific RegulatorPROMOTESEts1David-Fung et al 2006 Immunol. Rev.
DN3 Specific RegulatorPROMOTESEts2David-Fung et al 2006 Immunol. Rev.
DN3 Specific RegulatorPROMOTESLEF-1David-Fung et al 2006 Immunol. Rev.
DN3 Specific RegulatorPROMOTESPou6f1David-Fung et al 2006 Immunol. Rev.
DN3 Specific RegulatorPROMOTESId3Rothenberg, Moore, Yui 2008 Nat Rev Immunol
DN3 Specific RegulatorPROMOTESNotch3Rothenberg, Moore, Yui 2008 Nat Rev Immunol
DN3 Specific RegulatorPROMOTESTcr-CAlphaRothenberg, Moore, Yui 2008 Nat Rev Immunol
DN3 Specific RegulatorPROMOTESSATB1E-S. David-Fung, unpublished
DN3 Specific RegulatorREPRESSESHigh-level GATA-3Taghon, Yui, Rothenberg 2007 Nat. Immunol.