| Upstream Node | Interaction Type | Target Node | Literature Evidence |
|---|
| Ikaros | PROMOTES | Other B-cell Different'n Genes | based on its requirement in B development; Thompson, E.C.et al.: Merkenschlager, Immunity. 2007 Mar;26(3):335-44; Reynaud D.et al.: Singh, Nat Immunol. 2008 epub Jun 22.PMID: 18568028 |
| Pax5 | PROMOTES | Other B-cell Different'n Genes | Cobaleda, C. & Busslinger, M. Nat Immunol. 2007 May;8(5):463-70. |
| E2A.E2A | PROMOTES | Other B-cell Different'n Genes | Murre, C. Nat Immunol. 2005 Nov;6(11):1079-86; Hagman, J., & Lukin, K. Curr Opin Immunol. 2006 Apr;18(2):127-34 |
| EBF antagonized by Notch signaling (Net EBF) | PROMOTES | Other B-cell Different'n Genes | Hagman, J., & Lukin, K. Curr Opin Immunol. 2006 Apr;18(2):127-34 |
| IL7R.STAT signal | PROMOTES | Other B-cell Different'n Genes | direct or indirect permissive effect for development |