| Upstream Node | Interaction Type | Target Node | Literature Evidence |
|---|---|---|---|
| PU.1 | PROMOTES | PU.1 transactivation | by definition |
| GATA-1 | REPRESSES | PU.1 transactivation | "Nerlov, C. … & Graf Blood. 2000 Apr 15;95(8):2543-51" |
| PU.1 transactivation | PROMOTES | PU1 activity | by definition |