Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
HEBcan	CD4	-0.74	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	CD4	-0.77	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBcan	CD4_24-	-0.72	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBcan	CD4_69-	-1.23	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBcan	CD8	-0.82	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	CD8	-0.57	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBcan	CD8_24-	-0.58	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBcan	CD8_69-	-1.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEB	DN1	-1.13	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
HEB	DN1	-0.69	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
HEBcan	DN1	-0.89	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	DN1	-0.89	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEB	DN2	-0.79	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
HEB	DN2	-0.57	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
HEBcan	DN2	-0.48	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	DN2	-0.54	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	DN2	-0.4	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBcan	DN2a	-0.62	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	DN2a	-0.8	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEB	DN3a	-0.24	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
HEB	DN3a	-0.12	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
HEBcan	DN3a	-0.2	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	DN3a	-0.25	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	DN3a	-0.25	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	DN3a	-0.02	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEB	DN3b	-0.51	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
HEB	DN3b	-0.1	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
HEBcan	DN3b	-0.51	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	DN3b	-0.46	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	DN3b	-0.43	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	DN3b	-0.19	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEB	DN4	-0.69	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
HEB	DN4	-0.17	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
.
HEBcan	DP	-0.05	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	DP	-0.13	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBcan	DP69-	-1.17	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	DP69-	-0.18	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBcan	GDT	-0.52	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
HEBcan	GDT	-0.55	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
HEBcan	LSK-	-1.77	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBcan	LSK-	-1.64	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBcan	LSK-	-1.7	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
HEBcan	LSK+	-1.72	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBcan	LSK+	-1.49	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBcan	LSK+	-1.74	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
HEBcan	PreM	-2.19	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBcan	PreM	-2.13	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBcan	PreM	-2.44	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
HEBcan	ProB	-1.37	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBcan	ProB	-1.44	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBcan	ProB	-1.77	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
HEBcan	ProT	-1.39	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBcan	ProT	-1	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
HEBcan	ProT	-0.96	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
HEBcan	BM	-0.87	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
HEBcan	Fliver	-0.1	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
HEBcan	Mast	-0.28	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
HEBCan	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
HEBCan	LZ_noDL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
HEBcan	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
HEBcan	LZ_noDL	-0.23	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
HEBcan	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
HEBcan	G3_DL	-0.03	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
HEBcan	KRRm_DL	0.05	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
HEBcan	LZ_noDL	-0.23	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
HEBcan	G3_noDL	-0.18	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
HEBcan	KRRm_noDL	-0.12	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
HEBCan	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBCan	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBCan	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBCan	DL_PU1	-0.15	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBCan	DL_PU1	-0.16	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBCan	DL_PU1	-0.23	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBCan	noDL_LZ	0.09	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBCan	noDL_LZ	-0.07	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBCan	noDL_LZ	-0.01	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBCan	noDL_PU1	-0.37	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBCan	noDL_PU1	-0.55	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
HEBCan	noDL_PU1	-0.39	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
.
HEBCan	Prmtv_LZ	-0.55	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	Prmtv_LZ	-0.39	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	Prmtv_PU1	-0.83	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	Prmtv_PU1	-1.14	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	ProT_PU1	-0.46	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	ProT_PU1	-0.69	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	ProT_PU1	-0.37	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	PreT_LZ	-0.28	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	PreT_LZ	-0.18	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	PreT_LZ	-0.07	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	PreT_PU1	-1.7	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	PreT_PU1	-0.43	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
HEBCan	PreT_PU1	-1.57	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
PU.1 modulated by Notch.DL	REPRESSES	HEB	Franco et al PNAS 2006
Notch.CSL	PROMOTES	HEB	Taghon, Yui, Rothenberg 2007 Nat. Immunol.
HEB	PROMOTES	E2A.HEB	by definition