Effect of Key Gene Perturbations

SynonymPerturbationQPCR ExpressionRelative ToData From
GM.CSFR.b.LZ_DL0LZ,DLNotch-Delta interaction data (Franco et al. 2006 PNAS)
GM.CSFR.b.LZ_noDL-0.13LZ,DLNotch-Delta interaction data (Franco et al. 2006 PNAS)
.
GM.CSFR.b.DL_LZ0DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
GM.CSFR.b.DL_LZ0DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
GM.CSFR.b.DL_LZ0DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
GM.CSFR.b.DL_PU10.3DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
GM.CSFR.b.DL_PU1-0.01DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
GM.CSFR.b.DL_PU10.33DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
GM.CSFR.b.noDL_LZ-0.11DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
GM.CSFR.b.noDL_LZ-0.18DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
GM.CSFR.b.noDL_LZ-0.1DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
GM.CSFR.b.noDL_PU10.08DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
GM.CSFR.b.noDL_PU10.49DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
GM.CSFR.b.noDL_PU10.35DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
.
M.CSF.R.repLZ_DL0LZ,DLNotch-Delta interaction data (Franco et al. 2006 PNAS)
M.CSF.R.repLZ_noDL0.06LZ,DLNotch-Delta interaction data (Franco et al. 2006 PNAS)
.
M.CSF.R.repDL_LZ0DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
M.CSF.R.repDL_LZ0DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
M.CSF.R.repDL_LZ0DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
M.CSF.R.repDL_PU10.81DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
M.CSF.R.repDL_PU10.82DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
M.CSF.R.repDL_PU10.49DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
M.CSF.R.repnoDL_LZ0.2DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
M.CSF.R.repnoDL_LZ0.74DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
M.CSF.R.repnoDL_LZ-0.77DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
M.CSF.R.repnoDL_PU10.85DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
M.CSF.R.repnoDL_PU10.61DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
M.CSF.R.repnoDL_PU10.5DL,LZPU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream NodeInteraction TypeTarget NodeLiterature Evidence
Egr2PROMOTESM-CSF-RKrysinska,H,et al.: Bonifer Mol Cell Biol. 2007 Feb;27(3):878-87
C.EBPaPROMOTESM-CSF-RPetrovick, M.S.et al.: Tenen, Mol Cell Biol. 1998 Jul;18(7):3915-25
Runx1PROMOTESM-CSF-RPetrovick, M.S.et al.: Tenen, Mol Cell Biol. 1998 Jul;18(7):3915-25
C.EBPaPROMOTESGM-CSF-RHohaus, S..et al.: Tenen, Mol Cell Biol. 1995 Oct;15(10):5830-45
PU1 activityPROMOTESGM-CSF-RHohaus, S..et al.: Tenen, Mol Cell Biol. 1995 Oct;15(10):5830-45. Note that C/EBPa contributes too (not shown)
PU1 activityPROMOTESM-CSF-RPetrovick, M.S.et al.: Tenen, Mol Cell Biol. 1998 Jul;18(7):3915-25; for early T cells also Dionne et al. 2005 Devel. Biol.