Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
Runx3	CD4	-0.64	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	CD4	-0.89	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx3	CD4_24-	-0.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx3	CD4_69-	-1.24	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx3	CD8	-0.58	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	CD8	-0.24	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx3	CD8_24-	-0.64	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx3	CD8_69-	-0.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx3	DN1	-0.37	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx3	DN1	-0.3	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx3	DN1	-0.02	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	DN1	-0.32	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx3	DN2	-0.44	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx3	DN2	-0.51	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx3	DN2	-0.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	DN2	-0.17	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	DN2	0	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx3	DN2a	-0.21	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	DN2a	-0.32	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx3	DN3a	-0.88	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx3	DN3a	-0.63	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx3	DN3a	-0.54	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	DN3a	-0.54	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	DN3a	-0.52	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	DN3a	-0.12	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx3	DN3b	-0.96	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx3	DN3b	-1.15	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx3	DN3b	-0.77	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	DN3b	-0.6	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	DN3b	-0.7	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	DN3b	-0.46	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx3	DN4	-1.32	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Runx3	DN4	-2.01	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
.
Runx3	DP	-0.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	DP	-1.24	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx3	DP69-	-1.13	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	DP69-	-1.22	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Runx3	GDT	-0.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Runx3	GDT	-0.32	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
Runx3	BM	-0.55	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Runx3	Mast	0.31	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Runx3	Fthymus	-0.31	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
Runx3	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
Runx3	LZ_noDL	0.05	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
Runx3	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
Runx3	LZ_noDL	0.08	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
Runx3	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Runx3	G3_DL	-0.02	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Runx3	KRRm_DL	-0.12	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Runx3	LZ_noDL	0.08	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Runx3	G3_noDL	-0.07	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Runx3	KRRm_noDL	-0.08	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
Runx3	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx3	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx3	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx3	DL_PU1	-0.1	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx3	DL_PU1	-0.08	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx3	DL_PU1	-0.05	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx3	noDL_LZ	0.07	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx3	noDL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx3	noDL_LZ	0.09	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx3	noDL_PU1	-0.28	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx3	noDL_PU1	-0.12	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Runx3	noDL_PU1	-0.14	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
.
Runx3	Prmtv_LZ	0.35	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	Prmtv_LZ	-0.03	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	Prmtv_PU1	-0.11	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	Prmtv_PU1	-0.37	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	ProT_PU1	-0.19	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	ProT_PU1	-0.5	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	ProT_PU1	-0.35	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	PreT_LZ	-0.24	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	PreT_LZ	-0.38	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	PreT_LZ	-0.31	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	PreT_PU1	-0.63	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	PreT_PU1	-0.55	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
Runx3	PreT_PU1	-0.59	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
DN2, DN3 Stage Negative Regulator	REPRESSES	Runx3	David-Fung et al 2006 Immunol. Rev., Taghon et al. 2006 Immunity
PU1 activity	REPRESSES	Runx3	Franco et al. 2006 PNAS
Runx3	PROMOTES	PU.1	possible interpretation of expression pattern in view of Huang, G.et al.: Tenen Nat Genet. 2008 Jan;40(1):51-60.