Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
Ets2	CD4	-1.8	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	CD4	-2.03	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets2	CD4_24-	-1.74	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets2	CD4_69-	-2.1	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets2	CD8	-2.24	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	CD8	-2.11	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets2	CD8_24-	-2.55	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets2	CD8_69-	-2.44	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets2	DN1	-2.65	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets2	DN1	-2.35	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets2	DN1	-2.8	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	DN1	-2.74	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets2	DN2	-2.58	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets2	DN2	-2.55	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets2	DN2	-2.15	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	DN2	-2.37	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	DN2	-2.49	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets2	DN2a	-2.54	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	DN2a	-2.58	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets2	DN3a	-1.44	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets2	DN3a	-1.48	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets2	DN3a	-1.1	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	DN3a	-1.34	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	DN3a	-1.62	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	DN3a	-1.49	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets2	DN3b	-1.8	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets2	DN3b	-1.68	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets2	DN3b	-1.77	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	DN3b	-1.77	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	DN3b	-1.92	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	DN3b	-1.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets2	DN4	-1.88	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets2	DN4	-1.62	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
.
Ets2	DP	-0.8	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	DP	-0.8	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets2	DP69-	-1.82	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	DP69-	-0.92	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets2	GDT	-2.04	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets2	GDT	-2.09	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
Ets2	BM	-0.51	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Ets2	Mast	-0.68	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Ets2	Fthymus	0.48	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
Ets2	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
Ets2	LZ_noDL	-0.39	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
Ets2	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
Ets2	LZ_noDL	-0.58	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
Ets2	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Ets2	G3_DL	-0.16	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Ets2	KRRm_DL	-0.12	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Ets2	LZ_noDL	-0.58	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Ets2	G3_noDL	-0.53	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Ets2	KRRm_noDL	-0.48	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
Ets2	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets2	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets2	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets2	DL_PU1	-0.49	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets2	DL_PU1	-0.4	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets2	DL_PU1	-0.56	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets2	noDL_LZ	-0.39	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets2	noDL_LZ	-0.4	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets2	noDL_LZ	-0.38	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets2	noDL_PU1	-1.28	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets2	noDL_PU1	-0.84	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets2	noDL_PU1	-1.02	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
Notch.CSL	PROMOTES	Ets2	Taghon et al 2007 Nat Immunol; Franco et al 2006 PNAS
PU1 activity	REPRESSES	Ets2	Franco et al 2006 PNAS
DN3 Specific Regulator	PROMOTES	Ets2	David-Fung et al 2006 Immunol. Rev.
Ets2	PROMOTES	Ets-repr	Conjectural: based on Ets target elements in PU.1 cis-reg region