Upstream Node | Interaction Type | Target Node | Literature Evidence |
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MAP kinase | PROMOTES | PU1 activity | Several modes, via p38 or other MAP kinases. Wang, J.M., Lai, & Yang-Yen Mol Cell Biol. 2003 Mar;23(6):1896-909; Himes, S.R.,et al.: Hume, J Immunol. 2006 Feb 15;176(4):2219-28. |
PU.1 antagonized by GATA-1 (net PU.1) | PROMOTES | PU1 activity | by definition |
PU1 activity | PROMOTES | Aiolos | Franco et al 2006 PNAS |
PU1 activity | PROMOTES | Bcl11A | Franco et al 2006 PNAS |
PU1 activity | REPRESSES | c-Kit | Franco et al 2006 PNAS (supplementary information, cell surface staining) |
PU1 activity | REPRESSES | E2A | Franco et al 2006 PNAS |
PU1 activity | REPRESSES | Egr3 | Franco et al 2006 PNAS |
PU1 activity | REPRESSES | Ets2 | Franco et al 2006 PNAS |
PU1 activity | REPRESSES | HEBAlt | Franco et al 2006 PNAS, Dionne et al 2005 Devel. Biol. |
PU1 activity | REPRESSES | Id3 | Franco et al 2006 PNAS |
PU1 activity | PROMOTES | IL-7RAlpha | DeKoter, R. P.et al.: Singh Immunity. 2002 Feb;16(2):297-309. |
PU1 activity | PROMOTES | Mac-1 | Franco et al 2006 PNAS; Laiosa, C.V.et al.: Graf, Immunity. 2006 Nov;25(5):731-44. for effect in thymocytes; many other refs for other cells |
PU1 activity | PROMOTES | Pou6f1 | Franco et al 2006 PNAS |
PU1 activity | PROMOTES | PU.1 modulated by Notch.DL | by definition |
PU1 activity | REPRESSES | SpiB | Franco et al 2006 PNAS |
PU1 activity | PROMOTES | GM-CSF-R | Hohaus, S..et al.: Tenen, Mol Cell Biol. 1995 Oct;15(10):5830-45. Note that C/EBPa contributes too (not shown) |
PU1 activity | PROMOTES | Egr2 | Laslo, P.et al.: Singh Cell. 2006 Aug 25;126(4):755-66; and Franco et al 2006 PNAS, and Dionne et al. 2005 Devel. Biol. |
PU1 activity | PROMOTES | F4.80 | Franco et al PNAS 2006 |
PU1 activity | REPRESSES | IL-7RAlpha | Franco et al PNAS 2006 |
PU1 activity | PROMOTES | M-CSF-R | Petrovick, M.S.et al.: Tenen, Mol Cell Biol. 1998 Jul;18(7):3915-25; for early T cells also Dionne et al. 2005 Devel. Biol. |
PU1 activity | REPRESSES | Runx3 | Franco et al. 2006 PNAS |