Evidence for Interactions

Upstream NodeInteraction TypeTarget NodeLiterature Evidence
MAP kinasePROMOTESPU1 activitySeveral modes, via p38 or other MAP kinases. Wang, J.M., Lai, & Yang-Yen Mol Cell Biol. 2003 Mar;23(6):1896-909; Himes, S.R.,et al.: Hume, J Immunol. 2006 Feb 15;176(4):2219-28.
PU.1 antagonized by GATA-1 (net PU.1)PROMOTESPU1 activityby definition
PU1 activityPROMOTESAiolosFranco et al 2006 PNAS
PU1 activityPROMOTESBcl11AFranco et al 2006 PNAS
PU1 activityREPRESSESc-KitFranco et al 2006 PNAS (supplementary information, cell surface staining)
PU1 activityREPRESSESE2AFranco et al 2006 PNAS
PU1 activityREPRESSESEgr3Franco et al 2006 PNAS
PU1 activityREPRESSESEts2Franco et al 2006 PNAS
PU1 activityREPRESSESHEBAltFranco et al 2006 PNAS, Dionne et al 2005 Devel. Biol.
PU1 activityREPRESSESId3Franco et al 2006 PNAS
PU1 activityPROMOTESIL-7RAlphaDeKoter, R. P.et al.: Singh Immunity. 2002 Feb;16(2):297-309.
PU1 activityPROMOTESMac-1Franco et al 2006 PNAS; Laiosa, C.V.et al.: Graf, Immunity. 2006 Nov;25(5):731-44. for effect in thymocytes; many other refs for other cells
PU1 activityPROMOTESPou6f1Franco et al 2006 PNAS
PU1 activityPROMOTESPU.1 modulated by Notch.DLby definition
PU1 activityREPRESSESSpiBFranco et al 2006 PNAS
PU1 activityPROMOTESGM-CSF-RHohaus, S..et al.: Tenen, Mol Cell Biol. 1995 Oct;15(10):5830-45. Note that C/EBPa contributes too (not shown)
PU1 activityPROMOTESEgr2Laslo, P.et al.: Singh Cell. 2006 Aug 25;126(4):755-66; and Franco et al 2006 PNAS, and Dionne et al. 2005 Devel. Biol.
PU1 activityPROMOTESF4.80Franco et al PNAS 2006
PU1 activityREPRESSESIL-7RAlphaFranco et al PNAS 2006
PU1 activityPROMOTESM-CSF-RPetrovick, M.S.et al.: Tenen, Mol Cell Biol. 1998 Jul;18(7):3915-25; for early T cells also Dionne et al. 2005 Devel. Biol.
PU1 activityREPRESSESRunx3Franco et al. 2006 PNAS