| Upstream Node | Interaction Type | Target Node | Literature Evidence |
|---|
| Notch.CSL | PROMOTES | DN2, DN3 Stage Negative Regulator | conjectural; based on Notch requirement to reach DN2 stage |
| Bcl11B | PROMOTES | DN2, DN3 Stage Negative Regulator | Conjectural: from expression pattern and known repressor function |
| DN2, DN3 Stage Negative Regulator | REPRESSES | GATA-2 | Tydell et al. 2007 J. Immunol. |
| DN2, DN3 Stage Negative Regulator | REPRESSES | c-Kit | Taghon et al. 2006 Immunity; Yui & Rothenberg 2004 J. Immunol. |
| DN2, DN3 Stage Negative Regulator | REPRESSES | Gfi1B | David-Fung et al 2006 Immunol. Rev. |
| DN2, DN3 Stage Negative Regulator | REPRESSES | PU.1 | Anderson et al. 1999 Development; Anderson et al 2002 Immunity; Spain, L. M et. al.: Scott, J Immunol. 1999 Sep 1;163(5):2681-7; Lefebvre, J.M.et al.: Wiest J Immunol. 2005 May 15;174(10):6184-94.; David-Fung et al 2006 Immunol. Rev. |
| DN2, DN3 Stage Negative Regulator | REPRESSES | SCL.Tal-1 | Herblot, S. & Hoang, Nat Immunol. 2000 Aug;1(2):138-44; Rothenberg, Moore, Yui 2008 Nat Rev Immunol; Tydell et al. 2007 J. Immunol. |
| DN2, DN3 Stage Negative Regulator | REPRESSES | C.EBPa | Rothenberg, Moore, Yui 2008 Nat Rev Immunol |
| DN2, DN3 Stage Negative Regulator | REPRESSES | Runx3 | David-Fung et al 2006 Immunol. Rev., Taghon et al. 2006 Immunity |