Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
Gfi1	CD4	-1.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	CD4	-1.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Gfi1	CD4_24-	-3.35	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Gfi1	CD4_69-	-1.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Gfi1	CD8	-2.19	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	CD8	-3.72	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Gfi1	CD8_24-	-2.26	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Gfi1	CD8_69-	-2.09	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Gfi1	DN1	-1.19	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Gfi1	DN1	-1.13	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Gfi1	DN1	-1.26	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	DN1	-1.42	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Gfi1	DN2	-1.14	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Gfi1	DN2	-1.13	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Gfi1	DN2	-0.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	DN2	-0.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	DN2	-1.11	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Gfi1	DN2a	-1.12	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	DN2a	-1.12	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Gfi1	DN3a	-0.99	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Gfi1	DN3a	-1.03	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Gfi1	DN3a	-0.32	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	DN3a	-0.48	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	DN3a	-0.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	DN3a	-0.64	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Gfi1	DN3b	-1.21	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Gfi1	DN3b	-1.1	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Gfi1	DN3b	-0.82	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	DN3b	-0.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	DN3b	-1.18	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	DN3b	-1.04	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Gfi1	DN4	-1.47	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Gfi1	DN4	-1.14	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
.
Gfi1	DP	-0.92	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	DP	-1.03	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Gfi1	DP69-	-1.49	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	DP69-	-0.92	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Gfi1	GDT	-1.6	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Gfi1	GDT	-1.55	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
Gfi1	BM	-0.22	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Gfi1	Mast	-0.27	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Gfi1	Fthymus	-0.22	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
Gfi1	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
Gfi1	LZ_noDL	-0.19	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
Gfi1	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
Gfi1	LZ_noDL	-0.28	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
Gfi1	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Gfi1	G3_DL	-0.04	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Gfi1	KRRm_DL	0.08	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Gfi1	LZ_noDL	-0.28	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Gfi1	G3_noDL	-0.24	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Gfi1	KRRm_noDL	-0.05	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
Gfi1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Gfi1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Gfi1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Gfi1	DL_PU1	-0.27	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Gfi1	DL_PU1	-0.4	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Gfi1	DL_PU1	-0.3	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Gfi1	noDL_LZ	-0.26	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Gfi1	noDL_LZ	-0.27	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Gfi1	noDL_LZ	-0.03	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Gfi1	noDL_PU1	-1.31	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Gfi1	noDL_PU1	-0.74	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Gfi1	noDL_PU1	-0.9	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
Egr2	REPRESSES	Gfi1	Laslo, P.et al.: Singh Cell. 2006 Aug 25;126(4):755-66
Gfi1B	REPRESSES	Gfi1	Doan, L. L.et al.: Grimes Nucleic Acids Res. 2004 May 6;32(8):2508-19; Xu, W. and Kee, B. L. Blood. 2007 May 15;109(10):4406-14
PU.1 modulated by Notch.DL	REPRESSES	Gfi1	Franco et al PNAS 2006
Net E protein activity	PROMOTES	Gfi1	Weak effect: Schwartz, R.,et al.: Murre, Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9976-81; Xu, W. and Kee, B. L. Blood. 2007 May 15;109(10):4406-14
Gfi1	REPRESSES	Egr2	Laslo, P.et al.: Singh Cell. 2006 Aug 25;126(4):755-66
Gfi1	REGULATES	Negative inputs	Conjectural link to PU.1 based on cis-regulatory DNA sequence and knockout phenotype