Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
Scl	CD4	-5.11	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	CD4	-5.19	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Scl	CD4_24-	-4.23	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Scl	CD4_69-	-5.62	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Scl	CD8	-5.37	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	CD8	-3.72	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Scl	CD8_24-	-4.27	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Scl	CD8_69-	-5.2	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Scl	DN1	-1.85	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN1	-1.55	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN1	-2.04	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN1	-1.7	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN1	-2	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	DN1	-2.06	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	DN1	-2.31	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
.
Scl	DN2	-3.8	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN2	-2.43	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN2	-2.05	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN2	-2.48	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	DN2	-2.57	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	DN2	-4	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
.
Scl	DN2a	-1.74	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN2a	-1.74	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN2a	-1.74	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN2a	-1.74	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Scl	DN2b	-2.24	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN2b	-2.38	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Scl	DN3a	-4	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN3a	-5.14	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN3a	-4.44	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN3a	-3.62	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN3a	-4.31	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN3a	-4.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN3a	-4.7	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	DN3a	-4.3	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	DN3a	-5	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
.
Scl	DN3b	-5.08	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN3b	-4.34	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN3b	-4.8	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN3b	-3.72	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DN3b	-4.52	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	DN3b	-5.52	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	DN3b	-5	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
.
Scl	DN4	-6.15	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	DN4	-5.52	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	DN4	-6	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
.
Scl	DP	-4.66	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DP	-4.66	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Scl	DP69-	-5.66	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	DP69-	-5.19	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Scl	GDT	-5.19	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Scl	GDT	-5.11	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Scl	LSK-	-2.41	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	LSK-	-2.35	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	LSK-	-2.26	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	LSK-	-1.92	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Scl	LSK-	-1.92	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Scl	LSK-	-1.82	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
Scl	LSK+	-1.92	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	LSK+	-1.92	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	LSK+	-1.82	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	LSK+	-2.41	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Scl	LSK+	-2.35	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Scl	LSK+	-2.26	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
Scl	PreM	-3.51	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	PreM	-3.46	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	PreM	-3.41	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	PreM	-3.51	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Scl	PreM	-3.46	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Scl	PreM	-3.41	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
Scl	ProB	-3.44	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	ProB	-3.57	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	ProB	-2.82	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	ProB	-3.44	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Scl	ProB	-3.57	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Scl	ProB	-2.82	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
.
Scl	ProT	-4	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	ProT	-3.7	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	ProT	-4	GAPD	LSK vs DN Stages (Tydell et al. 2007, The Journal of Immunology)
Scl	ProT	-3.85	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Scl	ProT	-3.8	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)
Scl	ProT	-3.85	GAPD	LSK vs ProT, ProB and pre-myeloid expressions (Tydell et al. 2007, The Journal of Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
SCL	BM	1.92	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
SCL	Fliver	3.05	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
SCL	Mast	3.07	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
SCL	Fthymus	1.55	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
SCL	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
SCL	LZ_noDL	-0.23	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
SCL	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
SCL	G3_DL	0.31	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
SCL	KRRm_DL	0.25	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
SCL	LZ_noDL	-0.23	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
SCL	G3_noDL	0.61	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
SCL	KRRm_noDL	0.6	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
DN2, DN3 Stage Negative Regulator	REPRESSES	SCL.Tal-1	Herblot, S. & Hoang, Nat Immunol. 2000 Aug;1(2):138-44; Rothenberg, Moore, Yui 2008 Nat Rev Immunol; Tydell et al. 2007 J. Immunol.
High-level GATA-3	PROMOTES	SCL.Tal-1	Taghon, Yui, Rothenberg 2007 Nat. Immunol.; Anderson, M. K. et al 2002 Devel. Biol.
GATA-1 antagonized by PU.1 (net GATA-1)	PROMOTES	SCL.Tal-1	bubble= net GATA-1 activity
SCL.Tal-1	REPRESSES	E2A antagonized by SCL.Tal1 (net E2A)	Bubble = net E2A escaping SCL/Tal1 heterodimer
SCL.Tal-1	PROMOTES	E2A.SCL	by definition