Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
Tcf7	CD4	0.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	CD4	-0.07	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Tcf7	CD4_24-	-0.1	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Tcf7	CD4_69-	-0.18	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Tcf7	CD8	-0.4	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	CD8	-0.15	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Tcf7	CD8_24-	-0.55	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Tcf7	CD8_69-	-0.66	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Tcf7	DN1	-0.38	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN1	-0.57	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN1	-0.51	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN1	-0.77	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7.8	DN1	-0.47	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Tcf7.8	DN1	-0.06	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
.
Tcf7	DN2	0.15	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN2	0	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN2	0.2	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7.8	DN2	0.08	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Tcf7.8	DN2	0.36	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
.
Tcf7	DN2a	0.15	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN2a	0.11	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN2a	0	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN2a	0	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Tcf7	DN2b	0.4	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN2b	0.4	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Tcf7	DN3a	0.26	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN3a	0.3	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN3a	0.32	bActin	Intrathymic T Cell Precursors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN3a	0.38	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN3a	0.15	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN3a	0.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN3a	0.61	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7.8	DN3a	0.35	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Tcf7.8	DN3a	0.54	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
.
Tcf7	DN3b	0.32	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN3b	0.23	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN3b	0.3	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DN3b	0.57	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7.8	DN3b	0.43	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Tcf7.8	DN3b	0.75	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
.
Tcf7.8	DN4	0.22	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Tcf7.8	DN4	0.8	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
.
Tcf7	DP	0.59	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DP	0.52	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Tcf7	DP69-	-0.17	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	DP69-	0.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Tcf7	GDT	0.04	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Tcf7	GDT	0.04	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
TCF.1	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
TCF.1	LZ_noDL	-0.17	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
TCF.1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
TCF.1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
TCF.1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
TCF.1	DL_PU1	-0.41	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
TCF.1	DL_PU1	-0.65	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
TCF.1	DL_PU1	-0.57	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
TCF.1	noDL_LZ	-0.12	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
TCF.1	noDL_LZ	-0.22	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
TCF.1	noDL_LZ	-0.16	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
TCF.1	noDL_PU1	-1.14	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
TCF.1	noDL_PU1	-0.88	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
TCF.1	noDL_PU1	-0.82	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
.
TCF.1	Prmtv_LZ	-0.37	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	Prmtv_LZ	-0.5	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	Prmtv_PU1	-1.09	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	Prmtv_PU1	-1.54	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	ProT_PU1	-0.78	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	ProT_PU1	-1.04	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	ProT_PU1	-0.7	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	PreT_LZ	-0.2	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	PreT_LZ	-0.31	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	PreT_LZ	-0.05	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	PreT_PU1	-0.95	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	PreT_PU1	-0.91	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
TCF.1	PreT_PU1	-0.57	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
.
TCF.7.8	BM	-1.99	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
TCF.7.8	Mast	-2.51	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
TCF.7.8	Fthymus	-0.09	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
TCF.7.8	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
TCF.7.8	LZ_noDL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
TCF.7.8	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
TCF.7.8	G3_DL	-0.19	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
TCF.7.8	KRRm_DL	-0.08	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
TCF.7.8	LZ_noDL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
TCF.7.8	G3_noDL	-0.7	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
TCF.7.8	KRRm_noDL	-0.46	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
Notch-mod. GATA-3	REPRESSES	TCF-1	Taghon et al 2007 Nat Immunol
PU.1 modulated by Notch.DL	REPRESSES	TCF-1	Franco et al PNAS 2006
TCF-1	PROMOTES	Bcl11B	Conjectural, based on cis-regulatory sequence and expression pattern
TCF-1	REGULATES	Negative inputs	Rosenbauer, F.et al.: Tenen, Nat Genet. 2006 Jan;38(1):27-37
TCF-1	REGULATES	Positive inputs	Rosenbauer, F.et al.: Tenen, Nat Genet. 2006 Jan;38(1):27-37
TCF-1	PROMOTES	NK Receptors	Held, W.,et al.: Clevers, Immunity. 1999 Oct;11(4):433-42