Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
Ets1	CD4	0	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	CD4	-0.24	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets1	CD4_24-	-0.18	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets1	CD4_69-	-0.12	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets1	CD8	-0.46	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	CD8	-0.48	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets1	CD8_24-	-0.64	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets1	CD8_69-	-0.44	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets1	DN1	-1.11	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets1	DN1	-0.8	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets1	DN1	-1.36	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	DN1	-1.52	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets1	DN2	-0.51	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets1	DN2	-0.42	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets1	DN2	-0.77	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	DN2	-0.4	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	DN2	-0.72	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets1	DN2a	-0.8	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	DN2a	-0.89	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets1	DN3a	-0.01	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets1	DN3a	-0.05	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets1	DN3a	0.23	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	DN3a	0	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	DN3a	-0.19	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	DN3a	-0.01	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets1	DN3b	-0.14	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets1	DN3b	0.06	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets1	DN3b	-0.11	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	DN3b	-0.21	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	DN3b	-0.44	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	DN3b	-0.36	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets1	DN4	-0.4	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
Ets1	DN4	-0.02	bActin	Immature Thymocyte Gene Expression Data (David-Fung et al. 2006 Immunological Reviews)
.
Ets1	DP	0	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	DP	-0.09	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets1	DP69-	-0.14	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	DP69-	-0.15	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
Ets1	GDT	-0.2	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
Ets1	GDT	-0.17	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
Ets1	BM	-0.53	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Ets1	Mast	-0.3	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
Ets1	Fthymus	0.11	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
Ets1	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
Ets1	LZ_noDL	-0.01	LZ,DL	Notch-Delta interaction data (Franco et al. 2006 PNAS)
.
Ets1	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
Ets1	LZ_noDL	0.03	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
Ets1	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Ets1	G3_DL	0.07	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Ets1	KRRm_DL	0.04	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Ets1	LZ_noDL	0.03	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Ets1	G3_noDL	-0.1	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
Ets1	KRRm_noDL	0.01	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
Ets1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets1	DL_LZ	0	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets1	DL_PU1	-0.33	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets1	DL_PU1	-0.24	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets1	DL_PU1	-0.52	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets1	noDL_LZ	0.02	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets1	noDL_LZ	-0.09	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets1	noDL_LZ	0.04	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets1	noDL_PU1	-1.04	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets1	noDL_PU1	-0.68	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)
Ets1	noDL_PU1	-0.66	DL,LZ	PU.1-Notch signaling interaction data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
PU.1 modulated by Notch.DL	REPRESSES	Ets1	Franco et al PNAS 2006
DN3 Specific Regulator	PROMOTES	Ets1	David-Fung et al 2006 Immunol. Rev.
Ets1	PROMOTES	Tcr-Beta	Wotton, D et al.: Owen, M. J. Mol Cell Biol. 1994 Jan;14(1):840-50; Kim, W.Y.et al.: Ito, EMBO J. 1999 Mar 15;18(6):1609-20
Ets1	PROMOTES	NK Cell Genes	Walunas,T.L et al.: Leiden J Immunol. 2000 Mar 15;164(6):2857-60.
Ets1	PROMOTES	Ets-repr	Conjectural: based on Ets target elements in PU.1 cis-reg region