| Upstream Node | Interaction Type | Target Node | Literature Evidence |
|---|---|---|---|
| E2A antagonized by SCL.Tal1 (net E2A) | PROMOTES | E2A.HEB | Bubble = net E2A escaping SCL/Tal1 heterodimer |
| HEBAlt | PROMOTES | E2A.HEB | Conjectural; from Wang, D.et al.: Anderson, J Immunol. 2006 Jul 1;177(1):109-19. |
| HEB | PROMOTES | E2A.HEB | by definition |
| E2A.HEB | PROMOTES | Net E protein activity | by definition |