LIST OF REFERENCES

  1. Chen F, Rowen L, Hood L, Rothenberg EV 2001. Differential transcriptional regulation of individual TCR V beta segments before gene rearrangement. J. Immunol. 166(3), 1771-1780.
  2. Anderson, M. K., Weiss, A. H., Hernandez-Hoyos, G., Dionne, C. J., and Rothenberg, E. V.  2002.  Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage.  Immunity 16, 285-296.
  3. Anderson, M. K., Hernandez-Hoyos, G., Dionne, C. J., Arias, A. M., Chen, D., and Rothenberg, E. V.  2002.  Definition of regulatory network elements for T-cell development by perturbation analysis with PU.1 and GATA-3.  Devel. Biol. 246, 103-121.
  4. Hernández-Hoyos, G., Anderson, M. K., Wang, C., Rothenberg, E. V., and Alberola-Ila, J.  2003.  GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation.  Immunity 19, 83-94.
  5. Yui MA, Rothenberg EV. 2004. Deranged early T cell development in immunodeficient strains of nonobese diabetic mice. J. Immunol 173(9), 5381-5391
  6. Taghon, T., David, E.-S., Zúñiga-Pflücker, J. C., and Rothenberg, E. V.  2005.  Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.  Genes Dev. 19, 965-978.
  7. David-Fung, E.-S., Yui, M. A., Morales, M., Wang, H., Taghon, T., Diamond, R. A., and Rothenberg, E. V.  2006.  Progression of regulatory gene expression states in fetal and adult pro-T cell developmentImmunol. Rev. 209, 212-236.
  8. Franco, C. B., Scripture-Adams, D. D., Proekt, I., Taghon, T., Weiss, A. H., Yui, M. A., Adams, S. L., Diamond, R. A., and Rothenberg, E. V.  2006.  Notch/Delta signaling constrains re-engineering of pro-T cells by PU.1.  Proc. Natl. Acad. Sci. USA 103, 11993-11998.
  9. Taghon T, Yui MA, Pant R, Diamond RA, Rothenberg EV. 2006. Developmental and Molecular Characterization of Emerging β- and γδ-Selected Pre-T Cells in the Adult Mouse Thymus Immunity. 24, 53-64.
  10. Wang D,Claus CL,Vaccarelli G., Braunstein M,Schmitt TM,Zuniga-Pflucker JC,Rothenberg EV, Anderson MK. 2006. The basic helix-loop-helix transcription factor HEBAlt is expressed in pro-T cells and enhances the generation of T cell precursors. J. Immunol. 177(1), 109-119.
  11. Tydell, C. C., David-Fung, E.-S., Moore, J. E., Rowen, L., Taghon, T., and Rothenberg, E. V.  2007.  Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway.  J. Immunol. 179, 421-438.
  12. Taghon, T., Yui, M. A., and Rothenberg, E. V.  2007.  Mast cell lineage diversion of T lineage precursor cells by the essential T cell transcription factor GATA-3.  Nat. Immunol. 8, 845-855. 
  13. Rothenberg, E. V., Moore, J. E., and Yui, M. A.  2008.  Launching the T-lineage developmental programme.  Nat. Rev. Immunol. 8, 9-21.
  14. Maillard, I., Fang, T. & Pear, W. S. 2005. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu. Rev. Immunol. 23, 945-974.
  15. Okada H, Watanabe T, Niki M, Takano H, Chiba N, Yanai N, Tani K, Hibino H, Asano S, Mucenski ML, Ito Y, Noda T, Satake M. 1998. AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene. Oncogene. 17(18), 2287-2293.
  16. Herblot S, Steff AM, Hugo P, Aplan PD, Hoang T. 2000. SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression. Nat Immunol. 1(2), 97-98.
  17. Carleton M, Ruetsch NR, Berger MA, Rhodes M, Kaptik S, Wiest DL. 1999. Signals transduced by CD3epsilon, but not by surface pre-TCR complexes, are able to induce maturation of an early thymic lymphoma in vitro. J. Immunol. 163(5), 2576-2585.
  18. Laslo P, Spooner CJ, Warmflash A, Lancki DW, Lee HJ, Sciammas R, Gantner BN, Dinner AR, Singh H. 2006. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell. 126(4), 755-766.
  19. Doan LL, Porter SD, Duan Z, Flubacher MM, Montoya D, Tsichlis PN, Horwitz M, Gilks CB, Grimes HL. 2004. Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells. Nucleic Acids Res. 32(8),2508-2519.
  20. Sun HX, Pan HJ, Pan Y. 2003. Haemolytic activities and immunologic adjuvant effect of Panax notoginseng saponins. Acta Pharmacol Sin. 24(11), 150-154.
  21. Huang G, Zhang P, Hirai H, Elf S, Yan X, Chen Z, Koschmieder S, Okuno Y, Dayaram T, Growney JD, Shivdasani RA, Gilliland DG, Speck NA, Nimer SD, Tenen DG. 2008. PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis. Nat Genet. 40, 51-60.
  22. LM Spain, A Guerriero, S Kunjibettu, EW Scott. 1999. T Cell Development in PU.1-Deficient Mice. The Journal of Immunology. 163,2681-2687.
  23. R Anderson, R Fassler, E Georges-Labouesse, RO Hynes, BL Bader, JA Kreidberg, K Schaible, J Heasman and C Wylie 1999. Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads. Development. 126(4), 1655-1664.
  24. M.S. Anderson, E.S. Venanzi, L. Klein, Z. Chen, S. Berzins, S.J. Turley, H. von Boehmer, R. Bronson, A. Dierich, C. Benoist and D. Mathis. 2002. Projection of an immunological self-shadow within the thymus by the aire protein. Science 298, 1395–1401.
  25. Walunas TL, Wang B, Wang CR, Leiden JM.. 2000. Cutting edge: the Ets1 transcription factor is required for the development of NK T cells in mice. J. Immunol. 164(6), 2857-60..
  26. Frank Rosenbauer, Bronwyn M Owens, Li Yu, Joseph R Tumang, Ulrich Steidl, Jeffery L Kutok, Linda K Clayton, Katharina Wagner, Marina Scheller, Hiromi Iwasaki, Chunhui Liu, Björn Hackanson, Koichi Akashi, Achim Leutz, Thomas L Rothstein, Christoph Plass and Daniel G Tenen 2006. Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1 Nature Genetics. 38, 27-37.
  27. Cornelis Murre 2005. Helix-loop-helix proteins and lymphocyte development. Nature Immunology. 6, 1079-1086.
  28. Engel I, Murre C. 2001. The function of E- and Id proteins in lymphocyte development. Nat. Rev. Immunol. 1(3), 193-199.
  29. Quong MW, Romanow WJ, Murre C. 2002. E protein function in lymphocyte development. Annu Rev Immunol. 20, 301-322.
  30. Helen Pettersson and Göran Forsberg 2002. Staphylococcal enterotoxin H contrasts closely related enterotoxins in species reactivity Immunology 106(1), 71–79.
  31. Petrovick MS, Hiebert SW, Friedman AD, Hetherington CJ, Tenen DG, Zhang DE 1998. Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1. Mol Cell Biol. 18(7),3915-3925.
  32. Pierre Pirot, Leo A. van Grunsven, Jean-Christophe Marine, Danny Huylebroeck and Eric J. Bellefroid 2004. Direct regulation of the Nrarp gene promoter by the Notch signaling pathway Biochemical and Biophysical Research Communications.322(2), 526-534.
  33. Hsu, L.Y., J. Lauring, H.E. Liang, S. Greenbaum, D. Cado, Y. Zhuang, and M.S. Schlissel. 2003. A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. Immunity. 19, 105–117.
  34. Agata Y, Tamaki N, Sakamoto S, Ikawa T, Masuda K, Kawamoto H, Murre C. 2007. Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47. Immunity. 27(6), 871-884.
  35. Grégoire JM, Roméo PH 1999. T-cell expression of the human GATA-3 gene is regulated by a non-lineage-specific silencer. J Biol Chem. 274(10), 6567-6578.
  36. Fang TC, Yashiro-Ohtani Y, Del Bianco C, Knoblock DM, Blacklow SC, Pear WS. 2007. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity. 27(1),100-110.
  37. Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, Busslinger M, McCright B, Gridley T, Flavell RA. 2007. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 27(1), 89-99.
  38. Yang XO, Doty RT, Hicks JS, Willerford DM. 2003. Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs. Blood 101(11), 4492-4499.
  39. Ivan Maillard1, LiLi Tu, Arivazhagan Sambandam, Yumi Yashiro-Ohtani, John Millholland, Karen Keeshan, Olga Shestova, Lanwei Xu, Avinash Bhandoola, and Warren S. Pear 2006. The requirement for Notch signaling at the ß-selection checkpoint in vivo is absolute and independent of the pre–T cell receptor. J Exp Med 203(10), 2239-45.
  40. Nakagawa M, Ichikawa M, Kumano K, Goyama S, Kawazu M, Asai T, Ogawa S, Kurokawa M, Chiba S. 2006. AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis. Blood 108(10), 3329-34.
  41. Dionne, C. J., Tse, K. Y., Weiss, A. H., Franco, C. B., Wiest, D. L., Anderson, M. K. & Rothenberg, E. V.  2005.  Subversion of T lineage commitment by PU.1 in a clonal cell line system  Dev. Biol. 280, 448–466.
  42. DeKoter RP, Lee HJ, Singh H. 2002.  PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors.  Immunity 16(2), 297-309.
  43. Laiosa CV, Stadtfeld M, Xie H, de Andres-Aguayo L, Graf T.  2006.  Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors  Immunity 25(5), 731-44.
  44. Okuno Y, Huang G, Rosenbauer F, Evans EK, Radomska HS, Iwasaki H, Akashi K, Moreau-Gachelin F, Li Y, Zhang P, Göttgens B, Tenen DG. 2005. Potential autoregulation of transcription factor PU.1 by an upstream regulatory element. Mol Cell Biol. 25(7), 2832-45.
  45. Chen, H. M., D. Ray-Gallet, P. Zhang, C. J. Hetherington, D. A. Gonzalez, D.-E. Zhang, F. Moreau-Gachelin, and D. G. Tenen. 1995. PU.1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene 11, 1549-1560.
  46. Okada H, Watanabe T, Niki M, Takano H, Chiba N, Yanai N, Tani K, Hibino H, Asano S, Mucenski ML, Ito Y, Noda T, Satake M. 1998. AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene. Oncogene 17(18), 2287-93.
  47. Carleton M, Haks MC, Smeele SA, Jones A, Belkowski SM, Berger MA, Linsley P, Kruisbeek AM, Wiest DL. 2002. Early growth response transcription factors are required for development of CD4(-)CD8(-) thymocytes to the CD4(+)CD8(+) stage. J Immunol. 168(4), 1649-58.
  48. Wotton D, Ghysdael J, Wang S, Speck NA, Owen MJ. 1994. Cooperative binding of Ets-1 and core binding factor to DNA. Mol Cell Biol. 14(1), 840-50.
  49. W Y Kim, M Sieweke, E Ogawa, H J Wee, U Englmeier, T Graf, Y Ito 1999. Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains. EMBO J 18(6), 1609-20.