Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
GATA.1	BM	0.61	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
GATA.1	Fliver	1.56	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
GATA.1	Mast	0.83	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
GATA.1	Fthymus	0.05	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
GATA.1	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
GATA.1	LZ_noDL	-0.12	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
GATA.1	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
GATA.1	G3_DL	0.48	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
GATA.1	KRRm_DL	0.45	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
GATA.1	LZ_noDL	-0.12	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
GATA.1	G3_noDL	0.63	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
GATA.1	KRRm_noDL	0.64	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
GATA-1	PROMOTES	GATA-1	Nishimura, S.et al.: Yamamoto. Mol Cell Biol. 2000 Jan;20(2):713-23
High-level GATA-3	PROMOTES	GATA-1	Taghon, Yui, Rothenberg 2007 Nat. Immunol.
GATA-1	PROMOTES	GATA-1 antagonized by PU.1 (net GATA-1)	bubble= net GATA-1 activity
GATA-1	REPRESSES	PU.1 antagonized by GATA-1 (net PU.1)	Nerlov, C.et al.: Graf Blood. 2000 Apr 15;95(8):2543-51