| Upstream Node | Interaction Type | Target Node | Literature Evidence |
|---|---|---|---|
| Negative inputs | PROMOTES | Runx + corepressor | Contextual inputs needed to direct Runx effect |
| Runx1 | PROMOTES | Runx + corepressor | by definition |
| Runx + corepressor | REPRESSES | PU.1 | M. Zarnegar unpublished; Huang, G.et al.: Tenen Nat Genet. 2008 Jan;40(1):51-60. |