Syllabus (Updated 1/18/2016)
Below you will find the sequence of lectures, a copy will be posted here after it is given. Please email the webmaster if it is not posted by the end of the day the lecture is given.
Lecture slides and other course materials:
Lecture 8 (Jan 28):
Evolution and genome manipulation & Brief comment on quantitating biological reactions
The new frontier of genome engineering with CRISPR-Cas9 (Optional reading)
Evolution and genome manipulation & Brief comment on quantitating biological reactions
The new frontier of genome engineering with CRISPR-Cas9 (Optional reading)
Lecture 9 (Feb 2):
Components of transcriptional regulatory machines ... & Bacterial modes of regulation, part 1
Components of transcriptional regulatory machines ... & Bacterial modes of regulation, part 1
Lecture 10 (Feb 4):
Bacterial Regulation, II
The different roles of tryptophan transfer RNA in regulating trp operon expression in E. coli versus B. subtilis (Optional reading)
Bacterial Regulation, II
The different roles of tryptophan transfer RNA in regulating trp operon expression in E. coli versus B. subtilis (Optional reading)
Lecture 11 (Feb 9):
Quantitative aspects of transcription factor binding and gene regulatory circuit design
Quantitative aspects of transcription factor binding and gene regulatory circuit design
Lecture 14 (Feb 18):
Epigenetics and gene regulation: new elements for transcriptional regulation in multicellular eukaryotes
Epigenetics and gene regulation: new elements for transcriptional regulation in multicellular eukaryotes
Lecture 15 (Feb 23):
Combinatoriality in cis and trans: transcriptional control in multicellular eukaryotes
Combinatoriality in cis and trans: transcriptional control in multicellular eukaryotes
Lecture 16 (Feb 25):
Developmental gene regulation: intersection with epigenetics and gene networks
Transcription factors: from enhancer binding to developmental control (Supplementary reading)
Developmental gene regulation: intersection with epigenetics and gene networks
Transcription factors: from enhancer binding to developmental control (Supplementary reading)