Research
Microfluidic long-term culture, manipulation and
imaging platform for C. elegans
(Primary student researchers: Xiquan Cui, Lap Man Lee)
In this project, we aim to develop a novel microfluidic tool
to confine and sustain a biological sample in an enclosed environment.
Bioscientist can use such a tool to monitor and observe the development
of a biological sample under the influence of different stimulations.
At this stage, we can trap a single C. elegans; feed it with
bacteria and special reagent; and immobilize it for high resolution
DIC and fluorescent imaging.
Figure 1. Trapping a single C. elegans.
Figure 2. High resolution DIC (a) and corresponding fluorescent
(b,c) images of C. elegans (at different focal depths) immobilized
by our new microfluidic tool.
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