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California Institute of Technology
Division of Biology and Biological Engineering
MC 114-96 | 1200 E. California Blvd.,
Pasadena, CA 91125
(626) 395-8351 phone
murphym [at] caltech dot edu

 


@bjorkmanlab

Our laboratory is interested in immune recognition of viral pathogens. We are investigating the immune responses against HIV-1 and other viruses, most recently SARS-CoV-2, in order to develop improved therapeutics and/or vaccines. We use X-ray crystallography, electron microscopy, and biochemistry to study pathogen glycoproteins and host immune proteins. Using structural information and alternate antibody architectures, we are engineering antibody-based reagents with increased potency and breadth. We are also investigating the structural correlates of potent antibody-mediated neutralization of HIV-1, SARS-CoV-2, and hepatitis C virus to better understand what leads to naturally-occurring potent neutralizing antibodies.

Anthony West has developed Variant Database, a SARS-CoV-2 mutation pattern query tool, 06/2021

HIVRADP01 2019 Project:
Developing Immunogens to Elicit Broadly Neutralizing anti-HIV-1Antibodies

-Pearl Meister Greengard Prize: Pamela Bjorkman, 2021

- Webinar: Pamela Bjorkman: Viruses, Antiviral
and Vaccines, 04/2020

- The HIV Life Cycle

Donate in memory of Will Lange, 2016
Earnest C. Watson Lecture, 2015
TEDxCaltech: New Anti-HIV Agents, 2013
Traveling with Purpose - Volunteering in India, 2012
World AIDS Day - News Conf on KNBC-TV, 2012
LA Theatre Works: Rosalind Franklin, 2011

Magnus Hoffmann wins Clauser Doctoral Prize, 2022
Rachel Galimidi wins Clauser Doctoral Prize, 2016
Louise Scharf, AIDS Vaccine Barcelona, 2013
Gwen Owens, Crystals in space, 2013
Gwen Owens in CASIS video, 2013