Bjorkman Lab - Monoclonal Antibodies |
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[A useful place to search for MAbs: The Developmental Studies Hybridoma Bank] We have submitted most of our hybridomas to the American Type Culture Collection (ATCC). Below is a brief summary of each antibody and a link to the ATCC page that describes how to order each hybridoma and how to grow it. If you need any other reagents from our lab, please send an e-mail to Pamela Bjorkman - (bjorkman[at]caltech.edu) with:
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Antibodies against cytomegalovirus class I MHC homologs (See Fahnestock, M.L., J.L. Johnson, R.M.R. Feldman, J.M. Neveu, W.S. Lane, and P.J. Bjorkman (1995) The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides. Immunity 3: 583-590 andChapman, T.L. and P.J. Bjorkman (1998) Characterization of a murine cytomegalovirus class I MHC homolog: Comparison to MHC molecules and to the human cytomegalovirus MHC homolog. J. Virol. 72: 460-466. |
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Hybridoma
Name Antigen
recognized Antigen ELISA Western
blot IP
& immunoaffinity chromatography live
cell staining ATCC
number ATCC 10C7 UL18 purified
UL18/B2m heterodimers CRL-2430 15C6 m144 gel
slice of m144 CRL-2431 19G4 m144 purfied
m144/human B2m heterodimers CRL-2432 pending
approval |
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Antibodies against FcRn (see Raghavan, M., L.N. Gastinel, M.Y. Chen, and P.J. Bjorkman (1994) Investigation of the interaction between the lass I MHC-related Fc receptor and its immunoglobulin G ligand. Immunity 1: 303-315. |
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Hybridoma
Name Antigen
recognized Antigen ELISA Western
blot IP
& immunoaffinity chromatography live
cell staining ATCC
number ATCC 1G3 FcRn purfied
rat. FcRn/B2m heterodimers CRL-2434 2G3 FcRn purfied
rat FcRn/B2m heterodimers CRL-2435 4C9 rat
B2m purfied
rat FcRn/B2m heterodimers CRL-2437 |
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Antibodies against HFE (see Lebrón, J.A.*, M.J. Bennett*, D.E. Vaughn, A.J. Chirino, P.M. Snow, G.A. Mintier, J.N. Feder and P.J. Bjorkman (1998) Crystal Structure of the Hemochromatosis Protein HFE and Characterization of its Interaction with Transferrin Receptor. Cell 93:111-123. (* these authors contributed equally to the work) andLebrón, J.A., H. Shen, P.J. Bjorkman and S. Ou (1999) Tolerization of adult mice to immunodominant protein before monoclonal antibody production. J. Immunol. Meth. 222/1-2: 59-63. |
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Hybridoma
Name Antigen
recognized Antigen ELISA Western
blot IP
& immunoaffinity chromatography live
cell staining ATCC
number ATCC 3A5 HFE purfied
human HFE/B2m heterodimers CRL-2440 1C3 HFE purfied
human HFE/B2m heterodimers CRL-2441 2A11 HFE purfied
human HFE/B2m heterodimers CRL-2442 2B7 HFE purfied
human HFE/B2m heterodimers CRL-2443 2A5 HFE purfied
human HFE/B2m heterodimers CRL-2444 |
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Antibodies against human Zn-alpha2-glycoprotein (ZAG) (see Sánchez, L.M., C. López-Otín and P.J. Bjorkman (1997) Biochemical characterization and crystallization of human Zn-alpha2-glycoprotein, a soluble class I MHC homolog. Proc. Natl. Acad. Sci. USA 94: 4626-4630. |
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The anti-ZAG mAbs are now available from Santa Cruz Biotechnology, Inc.: Contact: link to
purchase: ZAG
(1D4): sc-13585 |
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