Bjorklab Publications

Complete List of Published Work in MyBibliography

2023

268. Horns, F, Martinez, JA, Fan, C, Haque, M, Linton, JM, Tobin, V, Santat, L, Maggiolo, AO, Bjorkman, PJ, Lois, C, Elowitz, MB (2023) Engineering RNA export for measurement and manipulation of living cells. Cell 186, 1–17. doi:10.1016/j.cell.2023.06.013
Full pdf: https://authors.elsevier.com/sd/article/S0092-8674(23)00689-X

267. Hoffmann, MAG, Yang, Z, Huey-Tubman, KE, Cohen, AA, Gnanapragasam, PNP, Nakatomi, LM, Storm, KN, Moon, WJ, Lin, PJC, West Jr AP, Bjorkman, PJ (2023) ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines, Cell 186: 2380-2391.e9. doi:10.1016/j.cell.2023.04.024 (open access link)
See preview: Zost, SJ, Carnahan, RH. (2023) A budding new approach strengthens an important message Cell 186: 2283-2285. doi:10.1016/j.cell.2023.04.034
See commentary: Gao, G. (2023) Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19 (2023) Nature Immunology 24: 1056–1057. doi:10.1038/s41590-023-01539-5

266. Shrock, EL, Timms, RT, Kula, T, Mena, EL, West, AP Jr, Guo, R, Lee, IH, Cohen, AA, McKay, LGA, Bi, C, Leng, Y, Fujimura, E, Horns, F, Li, M, Wesemann, DR, Griffiths, A, Gewurz, BE, Bjorkman, PJ, Elledge, SJ. (2023) Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses. Science 380: 6640 eadc9498. PMCID: PMC10273302 doi:10.1126/science.adc9498

265. Braet, SM, Buckley, TSC, Venkatakrishnan, V, Dam, K-MA, Bjorkman, PJ, Anand, GS (2023) Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics eLife 12:e82584. doi:10.7554/eLife.82584

264. Hills, RA, Tan, TK, Cohen, AA, JKeeffe, JR, Keeble, AH, Gnanapragasam, PNP, Storm, KN, Hill, ML, Liu, S, Gilbert-Jaramillo, J, Afzal, M, Napier, A, James, WS, Bjorkman, PJ, Townsend, AR, Howarth, M (2023) Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology. bioRxiv 2023.02.24.529520 doi:10.1101/2023.02.24.529520

263. Gristick, HB*, Hartweger, H*, Loewe, M, van Schooten, J, Ramos, V, Oliviera, TY, Nishimura, Y, Koranda, NS, Wall, A, Yao, K-H, Poston, D, Gazumyan, A, Wiatr, M, Horning, M, Keeffe, JR, Hoffmann, MAG, Yang, Z, Abernathy, ME, Dam, KA, Gao, H, Gnanapragasam, PNP, Kakutani, LM, Pavlovitch-Bedzyk, AJ, Seaman, MS, Howarth, M, McGuire, AT, Stamatatos, L, Martin, MA, West, AP, Nussenzweig, MC, Bjorkman, PJ (2023) CD4 binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wild-type animals. Sci Immunol doi:10.1126/sciimmunol.ade6364 *Co-first authors.
Free-access link: https://www.science.org/stoken/author-tokens/ST-1025/full

262. Dam K-MA, Fan, C, Yang, Z, Bjorkman,PJ (2023) Structural characterization of HIV-1 Env heterotrimers bound to one or two CD4 receptors reveals intermediate Env conformations. bioRxiv 2023.01.27.525985 doi:10.1101/2023.01.27.525985

261. Huang, KY A, Chen, X, Mohapatra, A, Nguyen, HTV, Schimanski, L, Tan, TK, Rijal, P, Vester, SK, Hills, RA, Howarth, M, Keeffe, JR, Cohen, AA, Kakutani, LM, Wu, Y-M, Shahed-Al-Mahmud, M, Chou, Y-C, Bjorkman, PJ, Townsend, AR, Ma, C (2023) Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2. Nat Commun 14: 311. PMCID: PMC9852238 doi:10.1038/s41467-023-35949-8
Full pdf: https://rdcu.be/c32mj

2022

260. Yang, Z, Dam, K-MA, Gershoni, JM, Zolla-Pazner, S, Bjorkman, PJ (2022) Antibody recognition of CD4-induced open HIV-1 Env trimers. J Virology e01082-22. PMCID: PMC9769388 doi:10.1128/jvi.01082-22

259. Fan, C, Cohen, AA, Park, M, Hung, AF-H., Keeffe, JR, Gnanapragasam, PNP, Lee, YE, Gao, H, Kakutani, LM, Wu, Z, Kleanthous, H, Malecek, KE, Williams, JC, Bjorkman, PJ (2022) Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bindconserved sarbecovirus epitopes. Immunity 55(12):2419-2435.e10 PMCID: PMC9606073 doi:10.1016/j.immuni.2022.10.019
Immune Epitope Database and Analysis Resource (IEDB), Reference ID 1041591: http://www.iedb.org/refId/1041591

258. Dam, K-MA, Barnes, CO, Gristick, HB, Schoofs, T, Gnanapragasam, PNP, Nussenzweig, MC, Bjorkman, PJ (2022) HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design. Nat Commun 13: 6123. PMCID: PMC9576718 doi:10.1038/s41467-022-33860-2
Full pdf: https://rdcu.be/cXIkx

257. Dam, K-MA, Mutia, PS, Bjorkman, PJ (2022) Comparing methods for immobilizing HIV-1 SOSIPs in ELISAs that evaluate antibody binding. Sci Rep 12: 11172. PMCID: PMC9247892 doi/10.1038/s41598-022-15506-x
Full pdf: https://www.nature.com/articles/s41598-022-15506-x.pdf
Full text: https://www.nature.com/articles/s41598-022-15506-x.epdf?sharing_token=dt8-iGi_PKOlcXVAuiZKi9RgN0jAjWel9jnR3ZoTv0PhiVmxRJ7Bi-IZWLzVqF6ZHovEeWyvlR7PCco6ZLdNsXTs3Akz64Gbp_ab9JWjQTqG5Pbz8p6XNi1cQXjGzX0_rr49PMJKQUteZE_oJZD5Vg3xpX7uU-EDlAJ8KUhHXss%3D

256. Bozhanova, NG, Flyak, AI, Brown, BP, Ruiz, SE, Salas, J, Rho, S, Bombardi, RG, Myers, L, Soto, C, Bailey, JR, Crowe, JE Jr, Bjorkman, PJ, Meiler, J (2022) Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals. Nat Commun 13: 3178. PMCID: PMC9177688 doi:10.1038/s41467-022-30865-9

255. Cohen, AA*, van Doremalen, N*, Greaney, AJ, Andersen, H, Sharma, A, Starr, TN, Keeffe, JR, Fan, C, Schulz, JE, Gnanapragasam, PNP, Kakutani, LM, West Jr., AP, Saturday, G, Lee YE, Gao, H, Jette, CA, Lewis, MG, Tan, TK, Townsend, AR, Bloom, JD, Munster, VJ, Bjorkman, PJ (2022) Mosaic RBD nanoparticles protect against diverse sarbecovirus challenges in animal models. Science 377(6606):eabq0839. *Co-first authors PMCID: PMC9273039 doi:10.1126/science.abq0839
Press releases: CEPI; Caltech; Wellcome Leap; Wellcome Leap animation; Merkin Institute
Free-access link: https://www.science.org/stoken/author-tokens/ST-597/full

254. Barnes CO, Schoofs T, Gnanapragasam PNP, Golijanin J, Huey-Tubman KE, Gruell H, Schommers P, Suh-Toma N, Lee YE, Cetrulo Lorenzi JC, Piechocka-Trocha A, Scheid JF, West AP Jr, Walker BD, Seaman MS, Klein F, Nussenzweig MC, Bjorkman PJ. (2022) A naturally arising broad and potent CD4-binding site antibody with low somatic mutation. Sci Adv. 8(32): eabp8155. PMCID: PMC9374330 doi:10.1126/sciadv.abp8155

253. Needham, BD, Funabashi, M., Adame, MD, Wang, Z, Boktor, JC, Haney, J, Wu, W-L, Rabut, C, Ladinsky, MS, Hwang, S-J, Guo, Y, Zhu, Q, Griffiths, JA, Knight, R, Bjorkman, PJ, Shapiro, MG, Geschwind, DH, Holschneider, DP, Fischbach, MA, Mazmanian, SK (2022) A gut-derived metabolite alters brain activity and anxiety behaviour in mice. Nature 602: 647-653. PMCID: PMC9170029 doi:10.1038/s41586-022-04396-8

252. Yang, Z, Dam K-MA, Bridges, MD, Hoffmann, MAG, DeLaitsch, AT, Gristick, HB, Escolano, A, Gautam, R, Martin, MA, Nussenzweig, MC, Hubbell, WL, Bjorkman, PJ (2022) Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer. Nat Commun 13: 732. PMCID: PMC8826976 doi:10.1038/s41467-022-28424-3

251. Tanaka, S, Olson, CA, Barnes, CO, Higashide, W, Gonzalez, M, Taft, J, Richardson, A, Martin-Fernandez, M, Bogunovic, D, Gnanapragasam, PNP, Bjorkman PJ, Spilman, P, Niazi, K, Rabizadeh, S, Soon-Shiong, P (2022) Rapid Identification of Neutralizing Antibodies against SARS-CoV-2 Variants by mRNA Display, Cell Reports 38: 110348. PMCID: PMC8769934 doi:10.1016/j.celrep.2022.110348

250. Weber, T, Potthoff, J, Bizu, S, Labuhn, M, Dold, L, Schoofs, T, Horning, M, Ercanoglu, MS, Kreer, C, Gieselmann, L, Vanshylla, K, Langhans, B, Janicki, H, Ströh, LJ, Knops, E, Nierhoff, D, Spengler, U, Kaiser, R, Bjorkman, PJ, Krey, T, Bankwitz, D, Pfeifer, N, Pietschmann, T, Flyak, AI, Klein, F (2022) Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization, Immunity 55: 341-355. doi:10.1016/j.immuni.2021.12.00

249. Vanshylla, K, Fan, C, Wunsch, M, Poopalasingam, N, Meijers, M, Kreer, C, Kleipass, F, Ruchnewitz, D, Ercanoglu, MS, Gruell, H, Münn, F, Pohl, K, Janicki, H, Nolden, T, Bartl, S, Stein, SC, Augustin, M, Dewald, F, Gieselmann, L, Schommers, P, Schulz, TF, Sander, LE, Koch, M, Luksza, M, Lässig, M, Bjorkman, PJ, Klein, F (2022) Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers, Cell Host & Microbe 30: 69-82. PMCID: PMC8683262 doi:10.1016/j.chom.2021.12.010

2021

248. Escolano, A*, Gristick, HB*, Gautam, R*, DeLaitsch, AT*, Abernathy, ME, Yang, Z, Wang, H, Hoffmann, MAG, Nishimura, Y, Wang, Z, Koranda, N, Kakutani, LM, Gao, H, Gnanapragasam, PNP, Raina, H, Gazumyan, A, Cipolla, M, Oliveria, TY, Ramos, V, Irvine, DJ, Silva, M, West, AP, Keeffe, JR, Barnes, CO, Seaman, MS, Nussenzweig, MC, Martin, MA, Bjorkman, PJ (2021) Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env. Science Transl Med. 13: eabk1533. PMCID PMC8932345 (available on 2022-05-24) doi:10.1126/scitranslmed.abk1533. *Co-first authors.
Free-access link: https://www.science.org/stoken/author-tokens/ST-169/full

247. Woodward, DM, Ricks, E Jr., Bjorkman, PJ, Tsoulfas, P, Johnson, JE, Westmoreland, G, Wilkie, TM (2021) The Path of Science in Future Tibetan Buddhist Education. Front. Commun., 27 October 2021. doi:10.3389/fcomm.2021.731604

246. Abernathy, ME, Dam, K-MA, Esswein, SR, Jette, CA, Bjorkman, PJ (2021) How Antibodies Recognize Pathogenic Viruses: Structural Correlates of Antibody Neutralization of HIV-1, SARS-CoV-2, and Zika. Viruses 13:2106. PMCID: PMC8537525 doi:10.3390/v13102106

245. Abernathy, ME, Gristick, HB, Vielmetter, J, Keeffe, JR, Gnanapragasam, PNP, Lee, YE, Escolano, A, Gautam, R, Seaman, MS, Martin, MA, Nussenzweig, MC, Bjorkman, PJ (2021) Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope. npj Vaccines 6:126. PMCID: PMC8545924 doi:10.1038/s41541-021-00387-4

244. Brune, KD, Liekniņa, I, Sutov, G, Morris, AR, Jovicevic, D, Kalniņš, G, Kazāks, A, Kluga, R, Kastaljana, S, Zajakina, A, Jansons, J, Skrastiņa, D, Spunde, K, Cohen, AA, Bjorkman, PJ, Morris, HR, Suna, E, Tārs, K (2021) N-Terminal Modification of Gly-His-tagged Proteins with Azidogluconolactone. ChemBioChem 22: 3199-3207. doi:10.1002/cbic.202100381

243. Ullah, I, Prévost, J, Ladinsky, MS, Stone, H, Lu, M, Anand, SP, Beaudoin-Bussières, G, Symmes, K, Benlarbi, M, Ding, S, Gasser, R, Fink, C, Chen, Y, Tauzin, A, Goyette, G, Bourassa, C, Medjahed, H, Mack, M, Chung, K, Wilen, CB, Dekaban, GA, Dikeakos, JD, Bruce, EA, Kaufmann, DE, Stamatatos, L, McGuire, AT, Richard, J, Pazgier, M, Bjorkman, PJ, Mothes, W, Finzi, A, Kumar, P, Uchil, PD (2021) Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy. Immunity 54: 2143-2158.e15. PMCID: PMC8372518 doi:10.1016/j.immuni.2021.08.015

242. Jacobs, JL, Bain, W, Naqvi, A, Staines, B, Castanha, PMS, Yang, H, Boltz, VF, Barratt-Boyes, S, Marques, ETA, Mitchell, SL, Methé, B, Olonisakin, TF, Haidar, G, Burke, TW, Petzold, E, Denny, T, Woods, CW, McVerry, BJ, Lee, JS, Watkins, SC, St Croix, CM, Morris, A, Kearney, MF, Ladinsky, MS, Bjorkman, PJ, Kitsios, G, Mellors, JW. (2021) SARS-CoV-2 Viremia is Associated with COVID-19 Severity and Predicts Clinical Outcomes. Clin Infect Dis. ciab686. doi: 10.1093/cid/ciab686

241. West, AP, Wertheim, JO, Wang, JC, Vasylyeva, TI, Havens, JL, Chowdhury, MA, Gonzalez, E, Fang, CE, Di Lonardo, SS, Hughes, S, Rakeman, JL, Lee, HH, Barnes, CO, Gnanapragasam, PNP, Yang, Z, Gaebler, C, Caskey, M, Nussenzweig, MC, Keeffe, JR, Bjorkman, PJ (2021) Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York. Nat Commun 12: 4886. PMCID: PMC8352861 doi:10.1038/s41467-021-25168-4

240. Muecksch, F, Weisblum, Y, Barnes, CO, Schmidt, F, Schaefer-Babajew, D, Wang, Z, Lorenzi, JCC, Flyak, AI, DeLaitsch, AT, Huey-Tubman, KE, Hou, S, Schiffer, CA, Gaebler, C, Da Silva, J, Poston, D, Finkin, S, Cho, A, Cipolla, M, Oliveira, TY, Millard, KG, Ramos, V, Gazumyan, A, Rutkowska, M, Caskey, M, Nussenzweig, MC, Bjorkman, PJ, Hatziioannou, T, Bieniasz, PD (2021) Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations. Immunity 54: 1853-1868.e7. PMCID: PMC8323339 doi:10.1016/j.immuni.2021.07.008

239. Greaney, AJ, Starr, TN, Barnes, CO, Weisblum, Y, Schmidt, F, Caskey, M, Gaebler, C, Cho, A, Agudelo, M, Finkin, S, Wang, Z, Poston, D, Muecksch, F, Hatziioannou, T, Bieniasz, PD, Robbiani, DF, Nussenzweig, MC, Bjorkman, PJ, Bloom, JD. (2021) Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies. Nat Commun 12: 4196. PMCID: PMC8263750 doi:10.1038/s41467-021-24435-8

238. Haugh, KA, Ladinsky, MS, Ullah, I, Stone, HM, Pi, R, Gilardet, A, Grunst, MW, Kumar, P, Bjorkman, PJ, Mothes, W, Uchil, PD (2021) In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission. eLife 10: e64179. PMCID: PMC8298093 doi:10.7554/eLife.64179

237. Garber, AI, Kupper, M, Laetsch, DR, Weldon, SR, Ladinsky, MS, Bjorkman, PJ, McCutcheon, JP (2021) The evolution of interdependence in a four-way mealybug symbiosis. Genome Biol and Evol 13: evab123. PMCID: PMC8331144 doi:10.1093/gbe/evab123

236. Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park S, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier R. (2021) B-cell genomics behind cross-neutralizing response against SARS-CoV-2 variants and SARS-CoV. Cell 184: P3205-3221.e24. PMCID: PMC8064835 doi:10.1016/j.cell.2021.04.032

235. Jette, CA, Cohen, AA, Gnanapragasam, PNP, Muecksch, F, Lee, YE, Huey-Tubman, KE, Schmidt, F, Hatziioannou, T, Bieniasz, PD, Nussenzweig, MC, West, AP, Jr., Keeffe, JR, Bjorkman, PJ, Barnes, CO (2021) Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies. Cell Reports 36: 109760. PMCID: PMC8423902 doi:10.1016/j.celrep.2021.109760

234. Agudelo, M, Martin Palus, M, Keeffe, JR, Bianchini, F, Svoboda, P, Salát, J, Peace, A, Gazumyan, A, Cipolla, M, Kapoor, T, Guidetti, F, Yao, K-H, Elsterová, J, Teislerová, D, Chrdle, A, Hönig, V, Oliviera, T, West, AP, Lee, YE, Rice, CM, MacDonald, MR, Bjorkman, PJ, Růžek, D, Robbiani, DF, Nussenzweig, MC, (2021) Broad and Potent Neutralizing Human Antibodies to Tick-borne Flaviviruses Protect Mice from Disease. J Exp Med. 218: e20210236. PMCID: PMC8040517 doi:10.1084/jem.20210236

233. Jette, CA, Barnes, CO, Kirk, SM, Melillo, B, Smith, III AB, Bjorkman, PJ (2021) Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation. Nat Commun 12: 1950. PMCID: PMC8007822 doi:10.1038/s41467-021-21816-x

232. De Gasparo, R, Pedotti, M, Simonelli, L, Nickl, P, Muecksch, F, Cassaniti, I, Percivalle, E, Lorenzi, JCC, Mazzola, F, Magrì, D, Michalcikova, T, Haviernik, J, Honig, V, Mrazkova, B, Polakova, N, Fortova, A, Tureckova, J, Iatsiuk, V, Di Girolamo, S, Palus, M, Zudova, D, Bednar, P, Bukova, I, Bianchini, F, Mehn, D, Nencka, R, Strakova, P, Pavlis, O, Rozman, J, Gioria, S, Sammartino, JC, Giardina, F, Gaiarsa, S, Pan-Hammarström, Q, Barnes, CO, Bjorkman, PJ, Calzolai, L, Piralla, A, Baldanti, F, Nussenzweig, MC, Bieniasz, PD, Hatziioannou, T, Prochazka, J, Sedlacek, R, Robbiani, DF, Ruzek, D, Varani, L. (2021) Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice. Nature. 593: 424-428. PMCID: PMC7836104 doi:10.038/s41586-021-03461-y

231. Hoffmann, MAG, Kiefer, C, Bjorkman, PJ (2021) In vitro characterization of engineered red blood cells as potent viral traps against HIV-1 and SARS-Co-2. Mol. Ther. Methods Clin. Dev. 21: 161-170. PMCID: PMC7944778 doi:10.1016/j.omtm.2021.03.003

230. Cohen, AA, Yang, Z, Gnanapragasam, P, Ou, S, Dam, K-M, Wang, H, Bjorkman, PJ (2021) Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers. PLoS One 16: e0247963. PMCID: PMC7932532 doi:10.1371/journal.pone.0247963

229. Livanos, AE, Jha, D, Cossarini, F, Gonzalez-Reiche, AS, Tokuyama, M, Aydillo, T, Parigi, TL, Ladinsky, MS, Ramos, I, Dunleavy, K, Lee, B, Dixon, R, Chen, ST, Martinez-Delgado, G, Nagula, S, Bruce, EA, Ko, HM, Glicksberg, BS, Nadkarni, G, Pujadas, E, Reidy, J, Naymagon, S, Grinspan, A, Ahmad, J, Tankelevich, M, Bram, Y, Gordon, R, Sharma, K, Houldsworth, J, Britton, GJ, Chen-Liaw, A, Spindle, MP, Plitt, T, Wang, P, Cerutti, A, Faith, JJ, Colombel, J-F, Kenigsberg, E, Argmann, C, Merad, M, Gnjatic, S, Harpaz, N, Danese, S, Cordon-Cardo, C, Rahman, A, Schwartz, RE, Kumta, NA, Aghemo, A, Bjorkman, PJ, Petralia F, van Bakel, H, Garcia-Sastre, A, Mehandru, S (2021) Intestinal host response to SARS-CoV-2 infection and COVID-19 outcomes in patients with gastrointestinal symptoms. Gastroenterology 160: 2435-2450.e34. PMCID: PMC7931673 doi:10.1053/j.gastro.2021.02.056

228. Wang, Z, Schmidt, F, Weisblum, Y, Muecksch, F, Barnes, CO, Finkin, S, Schaefer-Babajew, D, Cipolla, M, Gaebler, C, Lieberman, JA, Yang, Z, Abernathy, ME, Huey-Tubman, KE, Hurley, A, Turroja, M, West, KA, Gordon, K, Millard, KG, Ramos, V, Da Silva, J, Xu, J, Colbert, RA, Patel, R, Dizon, J, Unson-O’Brien, C, Shimeliovich, I, Gazumyan, A, Caskey, M, Bjorkman, PJ, Casellas, R, Hatziioannou, T, Bieniasz, PD, Nussenzweig, MC (2021) mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants. Nature 592: 616–622. PMCID: PMC7836122 doi:10.1038/s41586-021-03324-6

227. Hensley, MK, Bain, WG, Jacobs, J, Nambulli, S, Parikh, U, Cillo, A, Staines, B, Heaps, A, Sobolewski, MD, Rennick, LJ, Macatangay, BJC, Klamar-Blain, C, Kitsios, GD, Methé, B, Somasundaram, A, Bruno, T, Cardello, C, Shan, F, Workman, C, Ray, P, Ray, A, Lee, J, Sethi, R, Schwarzmann, WE, Ladinsky, MS, Bjorkman, PJ, Vignali, DA, Duprex, WP, Agha, ME, Mellors, JW, McCormick, KD, Morris, A, Haidar, G (2021) Intractable COVID-19 and Prolonged SARS-CoV-2 Replication in a CAR-T-cell Therapy Recipient: A Case Study. Clin Infect Dis. 73: e815-e821 PMCID: PMC7929077 doi:10.1093/cid/ciab072225.

226. Gaebler, C, Wang, Z, Lorenzi, JCC, Muecksch, F, Finkin, S, Tokuyama, M, Cho, A, Jankovic, M, Schaefer-Babajew, D, Oliveira, TY, Cipolla, M, Viant, C, Barnes, CO, Bram, Y, Breton, G, Hägglöf, T, Mendoza, P, Hurley, A, Turroja, M, Gordon, K, Millard, KG, Ramos, V, Schmidt, F, Weisblum, Y, Jha, D, Tankelevich, M, Martinez-Delgado, G, Yee, J, Patel, R, Dizon, J, Unson-O’Brien, C, Shimeliovich, I, Robbiani, DF, Zhao, Z, Gazumyan, A, Schwartz, RE, Hatziioannou, T, Bjorkman, PJ, Mehandru, S, Bieniasz, PD, Caskey, M, Nussenzweig, MC (2021) Evolution of Antibody Immunity to SARS-CoV-2. Nature 591: 639-644. PMCID: PMC7654855 doi:10.1038/s41586-021-03207-w

225. Cohen, AA, Gnanapragasam, PNP, Lee, YE, Hoffman, PR, Ou, S, Kakutani, LM, Keeffe, JR, Wu, H-J, Howarth, M, West, AP, Barnes, CO, Nussenzweig, MC, Bjorkman, PJ (2021) Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice. Science 371: 735-741. PMCID: PMC7928838 doi:10.1126/science.abf6840
Abstract: http://science.sciencemag.org/cgi/content/abstract/science.abf6840?ijkey=Jl4Y1IU5.GGrM&keytype=ref&siteid=sci
Reprint: http://science.sciencemag.org/cgi/rapidpdf/science.abf6840?ijkey=Jl4Y1IU5.GGrM&keytype=ref&siteid=sci
Full Text: http://science.sciencemag.org/cgi/content/full/science.abf6840?ijkey=Jl4Y1IU5.GGrM&keytype=ref&siteid=sci

224. Bárcena, M, Barnes, CO, Beck, M, Bjorkman, PJ, Canard, B, Gao, GF, Gao, Y, Hilgenfeld, R, Hummer, G, Patwardhan, A, Santoni, G, Saphire, EO, Schaffitzel, C, Schendel, SL, Smith, JL, Thorn, A, Veesler, D, Zhang, P, Zhou, Q. (2021) Structural biology in the fight against COVID-19. Nat Struct Mol Biol 28: 2-7. doi:10.1038/s41594-020-00544-8

2020

223. Linsky, TW, Vergara, R, Codina, N, Nelson, JW, Walker, MJ, Su, W, Barnes, CO, Hsiang, T-Y, Esser-Nobis, K, Yu, K, Reneer, ZB, Hou, YJ, Priya, T, Mitsumoto, M, Pong, A, Lau, UY, Mason, ML, Chen, J, Chen, A, Berrocal, T, Peng, H, Clairmont, NS, Castellanos, J, Lin, Y-R, Josephson-Day, A, Baric, RS, Fuller, DH, Walkey, CD, Ross, TM, Swanson, R, Bjorkman, PJ, Gale Jr., M, Blancas-Mejia, LM, Yen, H-L, Silva, D-A (2020) De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2. Science 370: 1208-1214. PMCID: PMC7920261 doi:10.1126/science.abe0075

222. Wang, Z, Barnes, CO, Gautam, R, Cetrulo Lorenzi, JC, Mayer, CT, Oliveira, TY, Ramos, V, Cipolla, M, Gordon, KM, Gristick, HB, West, AP, Nishimura, Y, Raina, H, Seaman, MS, Gazumyan, A, Martin, M, Bjorkman, PJ, Nussenzweig, MC, Escolano, A (2020) A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch. eLife 9 :e61991. PMCID: PMC7577740 doi:10.7554/eLife.61991

221. Barnes, CO, Jette, CA, Abernathy, ME, Dam, K-M A, Esswein, SR, Gristick, HB, Malyutin, AG, Sharaf, NG, Huey-Tubman, KE, Lee, YE, Robbiani, DF, Nussenzweig, MC, West, AP, Bjorkman, PJ (2020) SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature 588: 682-687. PMCID PMC8092461 doi:10.1038/s41586-020-2852-1

220. Bain, WG, Peñaloza, HF, Ladinsky, MS, van der Geest, R, Sullivan, M, Ros, M,Kitsios, GD, Methe, B, McVerry, BJ, Morris, A, Watson, AM, Watkins, SC, St Croix, CM, Stolz, DB, Bjorkman, PJ, Lee, JS (2021) Lower respiratory tract myeloid cells harbor SARS-CoV-2 and display an inflammatory phenotype, CHEST 159: 963-966. PMCID: PMC7671922 doi:10.1016/j.chest.2020.10.083

219. Ladinsky, MS, Gnanapragasam, PNP, Yang, Z, West Jr., AP, Kay, MS, Bjorkman PJ (2020) Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate. eLife 9: e58411. PMCID: PMC7394545 doi:10.7554/eLife.58411

218. Hoffmann, MAG, Bar-On, Y, Yang, Z, Gristick, HB, Gnanapragasam, PNP, Vielmetter, J, Nussenzweig, MC, Bjorkman, PJ (2020) Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells, Proc Natl Acad Sci USA. 117: 18719-18728. PMCID: PMC7414181 doi:10.1073/pnas.2010320117

217. Barnes, CO, West Jr., AP, Huey-Tubman, KE, Hoffmann, MAG, Sharaf, NG, Hoffman, PR, Koranda, N, Gristick, HB, Gaebler, C, Muecksch, F, Cetrulo Lorenzi, JC, Finkin, S, Hägglöf, T, Hurley, A, Millard, KG, Weisblum, Y, Schmidt, F, Hatziioannou, T, Bieniasz, PD, Caskey, M, Robbiani, DF, Nussenzweig, MC, Bjorkman, PJ (2020) Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies, Cell 182: 828-842. PMCID: PMC7311918 doi:10.1016/j.cell.2020.06.025

216. Robbiani, DF, Gaebler, C, Muecksch, F, Lorenzi, JCC, Wang, Z, Cho, A, Agudelo, M, Barnes, CO, Gazumyan, A, Finkin, S, Hägglöf, T, Oliveira, TY, Viant, C, Hurley, A, Hoffmann, HH, Millard, KG, Kost, RG, Cipolla, M, Gordon, K, Bianchini, F, Chen, ST, Ramos, V, Patel, R, Dizon, J, Shimeliovich, I, Mendoza, P, Hartweger, H, Nogueira, L, Pack, M, Horowitz, J, Schmidt, F, Weisblum, Y, Michailidis, E, Ashbrook, AW, Waltari, E, Pak, JE, Huey-Tubman, KE, Koranda, N, Hoffman, PR, West AP Jr, Rice, CM, Hatziioannou, T, Bjorkman, PJ, Bieniasz, PD, Caskey, M, Nussenzweig, MC (2020) Convergent antibody responses to SARS-CoV-2 in convalescent individuals. Nature 584: 437-442. PMCID: PMC7442695 doi:10.1038/s41586-020-2456-9.

215. Esswein, SR, Gristick, HB, Jurado, A, Peace, A, Keeffe, JR, Lee, YE, Voll, AV, MacDonald, MR, Rice, CM, Nussenzweig, MC, Robbiani, DF, Bjorkman, PJ (2020) Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody. Proc Natl Acad Sci USA 117: 9865-9875. PMCID: PMC7211955 doi:10.1073/pnas.1919269117

214. Van Rompay, KKA, Coffey, LL, Kapoor, T, Gazumyan, A, Keesler, RI, Jurado, A, Peace, A, Agudelo, M, Watanabe, J, Usachenko, J, Singapuri, A, Immareddy, R, Ardeshir, A, Stuart, JB, Bournazos, S, Ravetch, JV, Balderes, PJ, Lorenz, IC, Esswein, SR, Keeffe, JR, Bjorkman, PJ, Wang, Q, Rice, CM, MacDonald, MR, Nussenzweig, MC, Robbiani, DF (2020) A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques. Proc Natl Acad Sci USA. 117: 7981-7989. PMCID PMC7149495 doi:10.1073/pnas.2000414117

213. Flyak, AI, Ruiz, SE, Salas, J, Rho, S, Bailey, JR, Bjorkman, PJ (2020) An ultralong CDRH2 in an HCV neutralizing antibody demonstrates structural plasticity of antibodies against the E2 glycoprotein. eLife 9: e53169. PMCID: PMC7064334 doi:10.7554/eLife.53169

212. *Schommers, P, *Gruell, H, *Abernathy, ME, Tran, M-K, Dingens, AS, Gristick, HB, Barnes, CO, Schoofs, T, Schlotz, M. Vanshylla, K, Kreer, C, Weiland, D, Holtick U, Scheid, C, Valter, MM, van Gils, MJ, Sanders RW, Vehreschild, JJ, Cornely, OA, Lehmann, C, Fatkenheuer, G, Seaman, MS, Bloom, JD, Bjorkman PJ, Klein, F. (2020) Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody. Cell 180: 471-489. *co-first authors. PMCID: PMC7042716 doi:10.1016/j.cell.2020.01.010

211. Bjorkman PJ. (2020) Can we use structural knowledge to design a protective vaccine against HIV-1? HLA 95: 95-103. doi:10.1111/tan.13759

2019

210. Yang, Z, Wang, H, Liu, AZ, Gristick, HB, Bjorkman, PJ (2019) Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody reveals intermediate states induced by CD4 binding. Nature Struct Mol Biol 26: 1167-1175. PMCID: PMC6899201 doi:10.1038/s41594-019-0344-5

209. Einav, T, Yazdi, S, Coey, A, Bjorkman, PJ, Phillips, R (2019) Harnessing Avidity: Quantifying the Entropic and Energetic Effects of Linker Length and Rigidity for Multivalent Binding of Antibodies to HIV-1. Cell Systems 9:466-474. PMCID: PMC689228 doi:10.1016/j.cels.2019.09.007

208 Ladinsky, MS, Khamaikawin, W, Jung, Y, Lin, S, Lam, J, An, DS, Bjorkman, PJ, Kieffer, C (2019) Mechanisms of virus dissemination in bone marrow of HIV-1–infected humanized BLT mice. eLife 8: e46916. PMCID: PMC6839903 doi:10.7554/eLife.46916

207. Bublitz, DC, Chadwick, GL, Magyar, JS, Sandoz, KM, Brooks, DM, Mesnage, S, Ladinsky, MS, Garber, AI, Bjorkman, PJ, Orphan, VJ, McCutcheon, JP (2019) Peptidoglycan Production by an Insect-Bacterial Mosaic. Cell 179: 1-10. PMCID: PMC6838666 doi:10.1016/j.cell.2019.08.054

206. *Escolano, A, *Gristick, HB, Abernathy, ME, Merkenschlager, J, Gautam, R, Oliveira, TY, Pai, J, West, AP, Barnes, CO, Cohen, AA, Wang, H, Golijanin, J, Yost, D, Keeffe, JR, Wang, Z, Zhao, P, Yao, K-H, Bauer, J, Nogueira, L, Gao, H, Voll, AV, Montefior, DC, Seaman, MS, Gazumyan, A, Silva, M, McGuire, AT, Stamatatos, L, Irvine, DJ, Wells, L, Martin, MA, Bjorkman, PJ, Nussenzweig, MC (2019) Immunization expands HIV-1 glycan patch-specific B-cells in mice and macaques. Nature 570: 468-73. *co-first authors. PMCID: PMC6657810 doi:10.1038/s41586-019-1250-z

205. *Schoofs, T, *Barnes, CO, Suh-Toma, N, Golijanin, J, Schommers, P, Gruell, H, West, AP, Back, F, Lee, YE, Nogueria, L, Georgiev, IS, Bailer, RT, Czartoski, J, Mascola, JR, Seaman, MS, McElrath, MJ, Doria-Rose, NA, Klein, F, Nussenzweig, MC, Bjorkman, PJ (2019) Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope. Immunity 50: 1513-29. *co-first authors. PMCID: PMC6591006 doi:10.1016/j.immuni.2019.04.014

204. Ladinsky, MS, Araujo, LP, Zhang, X, Veltri, J, Galan-Diez, M, Soualhi, S, Lee, C, Irie, K, Pinker, EY, Narushima, S, Bandyopadhyay, S, Nagayama, M, Elhenawy, W, Coombes, BK, Ferraris, RP, Honda, K, Iliev, ID, Gao, N, Bjorkman PJ, Ivanov, II (2019) Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis. Science 363: eaat4042, 08 Mar 2019. PMCID: PMC6708280 doi:10.1126/science.aat4042

203. Uchil, PD, Pi, R, Haugh, KA, Ladinsky, MS, Ventura, JD, Barrett, BS, Santiago, ML, Bjorkman, PJ, Kassiotis, G, Sewald, X, Mothes, W. (2019) A Protective Role for the Lectin CD169/Siglec-1 against a Pathogenic Murine Retrovirus. Cell Host Microbe 25: 87-100. PMCID: PMC6331384 doi:10.1016/j.chom.2018.11.011

2018

202. Kinchen, VJ, Zahid, MN, Flyak, AI, Soliman, MG, Learn, GH, Wang, S, Davidson, E, Doranz, BJ, Ray, SC, Cox, AL, Crowe, JE Jr, Bjorkman, PJ, Shaw, GM, Bailey, JR. (2018) Broadly Neutralizing Antibody Mediated Clearance of Human Hepatitis C Virus Infection. Cell Host Microbe 24: 717-730.e5. PMCID: PMC6250073 doi:10.1016/j.chom.2018.10.012

201. Flyak, AI, Ruiz, S, Colber,t MD, Luong, T, Crowe, JE Jr, Bailey, JR, Bjorkman, PJ. (2018) HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design. Cell Host Microbe 24: 703-716. PMCID: PMC6258177 doi:10.1016/j.chom.2018.10.009

200. Keeffe, JR, Van Rompay, KKA, Olsen, PC, Wang, Q, Gazumyan, A, Azzopardi, SA, Schaefer-Babajew, D, Lee, YE, Stuart, JB, Singapuri, A, Watanabe, J, Usachenko, J, Ardeshir, A, Saeed, M, Agudelo, M, Eisenreich, T, Bournazos, S, Oliveira, TY, Rice, CM, Coffey, LL, MacDonald, MR, Bjorkman, PJ, Nussenzweig, M, Robbiani, DF. (2018). A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates. Cell Rep 25: 1385-1394 e1387. PMCID: PMC6268006 doi:10.1016/j.celrep.2018.10.031

199. Wang, H*, Barnes, CO*, Yang, Z, Nussenzweig, MC, Bjorkman, PJ (2018) Partially-open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion. Cell Host and Microbe 24: 579-592.e4. (*these authors contributed equally to the work) PMCID: PMC6185872 doi:10.1016/j.chom.2018.09.003

198. Mendoza, P, Gruell, H, Nogueira, L, Pai, JA, Butle,r AL, Millard, K, Lehmann, C, Suárez, I, Oliveira, TY, Lorenz,i JCC, Cohen, YZ, Wyen, C, Kümmerle, T, Karagounis, T, Lu, CL, Handl, L, Unson-O'Brien, C, Patel, R, Ruping, C, Schlotz, M, Witmer-Pack, M, Shimeliovich, I, Kremer, G, Thomas, E, Seaton, KE, Horowitz, J, West, AP Jr, Bjorkman PJ, Tomaras, GD, Gulick, RM, Pfeifer, N, Fätkenheue,r G, Seaman, MS, Klein, F, Caskey, M, Nussenzweig, MC (2018) Combination therapy with anti-HIV-1 antibodies maintains viral suppression. Nature 561: 479-484. PMCID: PMC6166473 doi:10.1038/s41586-018-0531-2

197. Stadtmueller, BM, Bridges, MD, Dam, K-M, Lerch, MT, Huey-Tubman, KE, Hubbell, WL, Bjorkman, PJ (2018) DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions. Immunity Aug 21, 49: 1-12. PMCID: PMC6104740 doi:10.1016/j.immuni.2018.06.017

196. Donaldson, GP, Ladinsky, MS, Yu, KB, Sanders, JG, Yoo, BB, Chou, WC. Conner, ME, Earl, AM, Knight, R, Bjorkman, PJ, Mazmanian, SK (2018) Gut microbiota utilize immunoglobulin A for mucosal colonization. Science 360: 795-800 PMCID: PMC5973787 doi:10.1126/science.aaq0926

195. Barnes, CO, Gristick, HB, Freund, NT, Escolano, A, Lyubimov, AY, Hartweger, H, West Jr, AP, Cohen, AE, Nussenzweig, MC, Bjorkman, PJ (2018) Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope. Nat Commun 9: 1251-1262. PMCID: PMC5871869 doi:10.1038/s41467-018-03632-y

2017

194. Gristick, HB, Wang, H, Bjorkman, PJ (2017) X-ray and EM structures of a natively glycosylated HIV-1 envelope trimer. Acta Cryst. D 73: 822–828. PMCID: PMC5633907 doi:10.1107/S2059798317013353

193. Kieffer, C, Ladinsky, MS, Bjorkman, PJ (2017) Multiscale imaging of HIV-1 transmission in humanized mice. AIDS Res Hum Retroviruses 33(S1):S6-S7. PMCID: PMC5685215 doi:10.1089/AID.2017.0142

192. Chiuppesi, F, Wussow, F, Scharf, L, Contreras, H, Gao, H, Meng, Z, Nguyen, J, Barry, PA, Bjorkman, PJ, Diamond, DJ. (2017) Comparison of homologous and heterologous prime-boost vaccine approaches using Modified Vaccinia Ankara and soluble protein to induce neutralizing antibodies by the human cytomegalovirus pentamer complex in mice. PLoS One 12(8):e0183377. PMCID: PMC5558987 doi:10.1371/journal.pone.0183377

191. Wang, H, Gristick, HB, Scharf, L, West, AP, Jr, Galimidi, RP, Seaman, MS, Freund, NT, Nussenzweig, MC, Bjorkman, PJ (2017) Asymmetric recognition of HIV-1 Env trimer by V1V2 loop-targeting antibodies. eLife 6: e27389. PMCID: PMC5472438 doi:10.7554/eLife.27389

190. Robbiani, DF, Bozzacco, L, Keeffe, JR, Khouri, R, Olsen, PC, Gazumyan, A, Schaefer-Babajew, D, Avila-Rio,s S, Nogueira, L, Pate,l R, Azzopardi, SA, Uhl, LFK, Saeed, M, Sevilla-Reyes, EE, Agudelo, M, Yao, KH, Golijanin, J, Gristick, HB, Lee, YE, Hurley, A, Caskey, M, Pai, J, Oliveira, T, Wunder, EA Jr, Sacramento, G, Nery, N Jr, Orge, C, Costa, F, Reis, MG, Thomas, NM, Eisenreich, T, Weinberger, DM, de Almeida, ARP, West, AP Jr, Rice, CM, Bjorkman, PJ, Reyes-Teran, G, Ko, AI, MacDonald, MR, Nussenzweig, MC (2017) Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico. Cell 169: 597-609. PMCID: PMC5492969 doi:10.1016/j.cell.2017.04.024

189. Gu, M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A (2017) LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Proc Natl Acad Sci USA 114: E2166-E2175. PMCID: PMC5358359 doi:10.1073/pnas.1613916114.

188. Kieffer, C, Ladinsky, MS, Ninh, A, Galimidi, RP, Bjorkman, PJ (2017) Longitudinal imaging of HIV-1 spread in humanized mice with parallel 3D immunofluorescence and electron tomography. eLife 6: e23282. PMCID: PMC5338924 doi:10.7554/eLife.2328

187. Freund, NT, Wang, H, Scharf, L, Nogueira, L, Horwitz, JA, Bar-On, Y, Golijanin, J, Sievers, SA, Sok, D, Cai, H, Cesar Lorenzi, JC, Halper-Stromberg, A, Toth, I, Piechocka-Trocha, A, Gristick, HB, van Gils, MJ, Sanders, RW, Wang, L-X, Seaman, MS, Burton, DR, Gazumyan, A, Walker, BD, West, AP, Bjorkman, PJ, Nussenzweig, MC(2017). Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller. Sci Transl Med 9: eaal2144. PMCID: PMC5467220 doi:10.1126/scitranslmed.aal2144

186. Caskey, M, Schoofs, T, Gruell, H, Settler, A, Karagounis, T, Kreider EF, Murrell, B, Pfeifer, N, Nogueira, L, Oliveira, TY, Learn, GH, Cohen, YZ, Lehmann, C, Gillor, D, Shimeliovich, I, Unson-O'Brien, C, Weiland, D, Robles, A, Kummerle, T, Wyen, C, Levin, R, Witmer-Pack, M, Eren, K, Ignacio, C, Kiss, S, West, AP Jr, Mouquet, H, Zingman BS, Gulick, RM, Keler, T, Bjorkman PJ, Seaman, MS, Hahn, BH, Fatkenheuer, G, Schlesinger, SJ, Nussenzweig, MC, Klein, F (2017). Antibody 10-1074 suppresses viremia in HIV-1-infected individuals. Nat Med 23: 185-191. PMCID: PMC5467219 doi:10.1038/nm.4268

2016

185. Wang, H, Cohen, AA, Galimidi, RP, Gristick, HB, Jensen, GJ, Bjorkman, PJ (2016). Cryo-EM structure of a CD4-bound open HIV-1 Envelope trimer reveals structural rearrangements of the gp120 V1V2 loop. Proc Natl Acad Sci USA 113: E7151-E7158. PMCID: PMC5135367 doi:10.1073/pnas.1615939113

184. Owens, GE, New, DM, Olvera, AI, Manzella, JA, Macon, BL, Dunn, JC, Coopper, DA, Rouleau, RL, Connor, DS, Bjorkman, PJ (2016) Comparative analysis of anti-polyglutamine Fab crystals grown on Earth and in microgravity. Acta Cryst F 72: 762-771. PMCID: PMC5053161 doi:10.1107/S2053230X16014011

183. Gristick, HB, von Boehmer, L, West, AP, Jr., Schamber, M, Gazumyan, A, Golijanin, J, Seaman, MS, Fätkenheuer, G, Klein, F, Nussenzweig, MC, Bjorkman, PJ (2016). Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site. Nat Struct Molec Biol 23: 906-915. PMCID: PMC5127623 doi:10.1038/nsmb.3291

182. Stadtmueller, BM, Yang, Z, Huey-Tubman, KE, Roberts-Mataric, H, Hubbell, WL, and Bjorkman, PJ (2016) Biophysical and biochemical characterization of avian secretory component provides structural insights into the evolution of the polymeric Ig receptor. J Immunol 197: 1408-1414. PMCID: PMC4976031 doi:10.4049/jimmunol.1600463

181. Scheid, JF, Horwitz, JA, Bar-On, Y, Kreider, EF, Lu, CL, Lorenzi, JC, Feldmann, A, Braunschweig, M, Nogueira, L, Oliveira, T, Shimeliovich, I, Pate,l R, Burke, L, Cohen, YZ, Hadrigan, S, Settler, A, Witmer-Pack, M, West, AP Jr, Juelg, B, Kele,r T, Hawthorne, T, Zingman, B, Gulick, RM, Pfeifer, N, Learn, GH, Seaman, MS, Bjorkman, PJ, Klein, F, Schlesinger, SJ, Walker, BD, Hahn, BH, Nussenzweig, MC, Caskey, M. (2016) HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption. Nature 535: 556-560. PMCID: PMC5034582 doi:10.1038/nature18929.

180. Schoofs, T, Klein, F, Braunschweig, M, Kreider, EF, Feldmann, A, Nogueira, L, Oliveira, T, Lorenzi, JC, Parrish, EH, Learn, GH, West, AP, Bjorkman, PJ, Schlesinger, SJ, Seaman, MS, Czartoski, J, McElrath, MJ, Pfeifer, N, Hahn, BH, Caskey, M, & Nussenzweig, MC (2016) HIV-1 Immunotherapy with Monoclonal Antibody 3BNC117 Elicits Host Immune Responses against HIV-1. Science 352: 997-1001. PMCID: PMC5151174 doi:10.1126/science.aaf0972

179. Scharf, L, West, AP, Jr, Sievers, SA, Chen, C, Jiang, S, Gao, H, Gray, MD, McGuire, AT, Scheid, JF, Nussenzweig, MC, Stamatatos, L, Bjorkman, PJ (2016) Structural basis for germline antibody recognition of HIV-1 immunogens. eLife 5:e13783. PMCID: PMC4811768 doi:10.7554/eLife.13783

178. Stadtmueller, BM, Huey-Tubman, KE, López, CJ, Yang, Z, Hubbell, WL, Bjorkman, PJ (2016) The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins. eLife 5:e10640. PMCID: PMC4786434 doi:10.7554/eLife.10640.001

177. Ahmed, AA, Keremane, SR, Vielmetter, J, Bjorkman, PJ (2016) Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa. J Struct Biol. 194: 78-89. PMCID: PMC4769027 doi:10.1016/j.jsb.2016.02.001

176. Ndjamen, B, Joshi, DS, Fraser, SE, Bjorkman, PJ (2016) Characterization of antibody bipolar bridging mediated by the human cytomegalovirus Fc receptor gp68. J Virol. 90: 3262-3267. PMCID: PMC4810659 doi:10.1128/JVI.02855-15

175. Ding S, Veillette M, Coutu M, Prévost J, Scharf L, Bjorkman PJ, Ferrari G, Robinson JE, Stürzel C, Hahn BH, Sauter D, Kirchhoff F, Lewis GK, Pazgier M, Finzi A. (2016) A Highly-Conserved Residue of the HIV-1-gp120 Inner Domain is Important for ADCC Responses Mediated by Anti-Cluster A Antibodies. J Virol. 90 :2127-2134. PMCID: PMC4733974 doi:10.1128/JVI.02779-15

174. Davenport, YW, West, AP, Jr., Bjorkman, PJ (2016) Structure of an HIV-2 gp120 in complex with CD4. J Virol 90 :2112-2118. PMCID: PMC4733984 doi:10.1128/JVI.02678-15

173. Morgand, M, Bouvin-Pley, M, Plantier, JC, Moreau, A, Alessandri, E, Simon, F, Pace, CS, Pancera, M, Ho, DD, Poignard, P, Bjorkman, PJ, Mouquet, H, Nussenzweig, MC, Kwong, PD, Baty, D, Chame, P, Braibant, M, Barin, F (2016) A V1V2 neutralizing epitope is conserved in divergent non-M groups of HIV-1. J Acquir Immune Defic Syndr 71: 237-245. PMCID: PMC4770367 doi:101097/QAI0000000000000854

2015

172. Freund, NT, Horwitz, JA, Nogueira, L, Sievers, SA, Scharf, L, Scheid, JF, Gazumyan, A, Liu, C, Velinzon, K, Goldenthal, A, Sanders, RW, Moore, JP, Bjorkman, PJ, Seaman, MS, Walker, BD, Klein, F, Nussenzweig, MC (2015) A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo. PLoS Pathog 11 :e1005238. PMCID: PMC4627763 doi:101371/journalppat1005238

171. Treweek, JB, Chan, KY, Flytzanis, NC, Yang, B, Deverman, BE, Greenbaum, A, Lignell, A, Xiao, C, Cai, L, Ladinsky, MS, Bjorkman, PJ, Fowlkes, CC, Gradinaru, V (2015) Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping. Nature Protocols 10: 1860-96. PMCID: PMC4917295 doi:101038/nprot2015122

170. Sewald, X, Ladinsky, MS, Uchil, PD, Beloor, J, Pi, R, Herrmann, C, Motamedi, N, Murooka, TT, Brehm, MA, Greiner, DL, Shultz, LD, Mempel, TR, Bjorkman, PJ, Kumar, P, Mothes, W (2015) Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection. Science 350 :563-567. PMCID: PMC4651917 doi:101126/scienceaab2749

169. Scharf, L, Wang, H, Gao, H, Chen, S, McDowall, AW, Bjorkman, PJ (2015) Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env. Cell 162: 1379–13. PMCID: PMC4587768 doi:101016/jcell201508035

168. Dosenovic, P, von Boehmer, L, Escolano, A, Jardine, J, Freund, NT, Gitlin, AD, McGuire, AT, Kulp, DW, Oliveira, T, Scharf, L, Pietzsch, J, Gray, MD, Cupo, A, van Gils, MJ, Yao, KH, Liu, C, Gazumyan, A, Seaman, MS, Björkman, PJ, Sanders, RW, Moore, JP, Stamatatos, L, Schief, WR, Nussenzweig, MC (2015) Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice. Cell 161: 1505-15. PMCID: PMC4604566 doi:101016/jcell201506003

167. Yoon, H, Macke, J, West, AP Jr, Foley, B, Bjorkman, PJ, Korber, B, Yusim, K, (2015) CATNAP: a tool to compile, analyze and tally neutralizing antibody panels. Nucleic Acids Res 43: W213-9. PMCID: PMC4489231 doi:101093/nar/gkv404

166. Owens, GE, New, D M, West, AP Jr, Bjorkman, PJ (2015) Anti-polyQ antibodies recognize a short polyQ stretch in both normal and mutant huntingtin exon 1. J Mol Biol 47: 2507-2519. PMCID: PMC4520773 doi:101016/jjmb201505023

165. Zhou, T, Lynch, RM, Chen, L, Acharya, P, Wu, X, Doria-Rose, NA, Joyce, MG, Lingwood, D, Soto, C, Bailer, RT, Ernandes, MJ, Kong, R, Longo, NS, Louder, MK, McKee, K, O'Dell, S, Schmidt, SD, Tran, L, Yang, Z, Druz, A, Luongo, TS, Moquin, S, Srivatsan, S, Yang, Y, Zhang, B, Zheng, A, Pancera, M, Kirys, T, Georgiev, IS, Gindin, T, Peng, HP, Yang, AS; NISC Comparative Sequencing Program, Mullikin, JC, Gray, MD, Stamatatos, L, Burton, DR, Koff, WC, Cohen, MS, Haynes, BF, Casazza, JP, Connors, M, Corti, D, Lanzavecchia, A, Sattentau, QJ, Weiss, RA, West, AP Jr, Bjorkman, PJ, Scheid, JF, Nussenzweig, MC, Shapiro, L, Mascola, JR, Kwong, PD (2015) Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell 161: 1-13. PMCID: PMC4683157 doi: 101016/jcell201505007.

164. Barbian, HJ, Decker, JM, Bibollet-Ruche, F, Galimidi, RP, West, AP Jr, Learn, GH, Parrish, NF, Iyer, SS, Li ,Y, Pace, CS, Song, R, Huang, Y, Denny, TN, Mouquet, H, Martin, L, Acharya, P, Zhang, B, Kwong, PD, Mascola, JR, Verrips, CT, Strokappe, NM, Rutten, L, McCoy, LE, Weiss, RA, Brown, CS, Jackson, R, Silvestri, G, Connors, M, Burton, DR, Shaw, GM, Nussenzweig, MC, Bjorkman, PJ, Ho, DD, Farzan, M, Hahn, BH (2015) Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas. MBio 6: e00296-15. PMCID: PMC4453581 doi:101128/mBio00296-15.

163. Sievers, SA, Scharf, L, West, AP Jr, Bjorkman, PJ (2015) Antibody engineering for increased potency,
breadth and half-life. Curr Opin HIV AIDS 10: 151-159. PMCID: PMC4465343 doi:101097/COH0000000000000148.

162. Galimidi, RP, Klein, JS, Politzer, MS, Bai, S, Seaman, MS, Nussenzweig, MC, West, AP Jr, Bjorkman, PJ (2015) Intra-Spike Crosslinking Overcomes Antibody Evasion by HIV-1. Cell 160: 433-446. PMCID: PMC4401576 doi:101016/jcell201501016.

161. Bjorkman, PJ (2015) Not Second Class: The First Class II MHC Crystal Structure. J Immunol 194: 3-4. doi:104049/jimmunol1402828.

2014

160. Klein, F, Nogueira, L, Nishimura, Y, Phad, G, West, AP Jr, Halper-Stromberg, A, Horwitz, JA, Gazumyan, A, Liu, C, Eisenreich, TR, Lehmann, C, Fätkenheuer, G, Williams, C, Shingai, M, Martin, MA, Bjorkman, PJ, Seaman, MS, Zolla-Pazner, S, Karlsson Hedestam, GB, Nussenzweig, MC (2014) Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants. J Exp Med 211: 2361-2372. PMCID: PMC4235636 doi:101084/jem20141050

159. Bouvin-Pley, M, Morgand, M, Meyer, L, Goujard, C, Moreau, A, Mouquet, H, Nussenzweig, M, Pace, C, Ho, D, Bjorkman, PJ, Baty, D, Chames, P, Pancera, M, Kwong, PD, Poignard, P, Barin, F, Braibant, M (2014) Drift of the HIV-1 envelope glycoprotein gp120 toward increased neutralization resistance over the course of the epidemic: a comprehensive study using the most potent and broadly neutralizing monoclonal antibodies. J Virol 88: 13910-13917. PMCID: PMCID: PMC4248973 doi:101128/JVI02083-14

158. *Klein, JS, *Jiang, S, *Galimidi, RP, Keeffe, JR, Bjorkman, PJ (2014) Design and characterization of structured protein linkers with differing flexibilities. Protein Eng Des and Sel 27: 325-330. (* these authors contributed equally to the work) PMCID: PMC4191447 doi: 101093/protein/gzu043

157. Shingai, M, Donau, OK, Plishka, RJ, Buckler-White, A, Mascola, JR, Nabel, GJ, Nason, MC, Montefiori, D, Moldt, B, Poignard, P, Diskin, R, Bjorkman, PJ, Eckhaus, MA, Klein, F, Mouquet, H, Cetrulo Lorenzi, JC, Gazumyan, A, Burton, DR, Nussenzweig, MC, Martin, MA, Nishimura, Y (2014) Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques. J Exp Med 211: 2061-2074. PMCID: PMC4172223 doi:101084/jem20132494

156. Ahmed, AA, Giddens, J, Pincetic, A, Lomino JV, Ravetch, JV, Wang, L-X, Bjorkman, PJ (2014) Structural characterization of anti-inflammatory Immunoglobulin G Fc proteins. J Mol Biol 426: 3166-3179. PMCID: PMC4159253 doi: 101016/jjmb201407006

155. Scharf, L, Scheid, JF, Lee, JH, West, AP, Chen, C, Gao, H, Gnanapragasam, PNP, Mares, R, Seaman, MS, Ward, AB, Nussenzweig, MC, Bjorkman, PJ (2014) Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike. Cell Rep 7: 785–795. PMCID: PMC4109818 doi: 101016/jcelrep201404001

154. Ndjamen, B, Farley, AH, Lee, T, Fraser, SE, Bjorkman, PJ (2014) The herpes virus Fc receptor gE-gI mediates antibody bipolar bridging to clear viral antigens from the cell surfac.e PLoS Pathogens 10:e1003961. PMCID: PMC3946383 doi: 101371/journalppat1003961

153. West, AP Jr, Scharf, L, Scheid, JF, Klein, F, Bjorkman PJ Nussenzweig, MC, (2014) Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy. Cell 156: 633-648. PMCID: PMC4041625 doi:101016/jcell201401052

152. Ladinsky, MS, Kieffer, C, Olson, G, Deruaz, M, Vrbanac, V, Tager, AM, Kwon, DS, Bjorkman, PJ (2014) Electron tomography of HIV-1 infection in gut-associated lymphoid tissue. PLoS Pathog 10 :e003899. PMCID: PMC3907528 doi: 101371/journalppat1003899

2013

151. Wu Y, West AP, Kim HJ, Thornton ME, Ward AB, Bjorkman PJ (2013) Structural basis for enhanced neutralization of HIV-1 by a dimeric IgG form of the glycan-recognizing antibody 2G12. Cell Rep 5:1443-1455. PMCID: PMC3919625 doiorg/101016/jcelrep201311015

150. Horwitz JA, Halper-Stromberg A, Mouquet H, Gitlin AD, Tretiakova A, Eisenreich TR, Malbec M, Gravemann S, Billerbeck E, Dorner M, Büning H, Schwartz O, Knops E, Kaiser R, Seaman MS, Wilson JM, Rice CM, Ploss A, Bjorkman PJ, Klein F, Nussenzweig MC (2013) HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. Proc Natl Acad Sci USA 110: 16538-16543. PMCID: PMC3799352 doi:101073/pnas1315295110

149. West, AP Jr, Scharf, L, Horwitz, J, Klein, F, Nussenzweig, MC, Bjorkman PJ (2013) Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residue.s Proc Natl Acad Sci USA 110: 10598-10603. PMCID: PMC3696754 doi:101073/pnas1309215110

148. Diskin, R, Klein, F, Horwitz, J, Halper-Stromberg, A, Sather, DN, Marcovecchio, PM, Lee, T, West, AP, Gao, H, Seaman, MS, Stamatatos, L, Nussenzweig, MC, Bjorkman, PJ (2013) Restricting HIV-1 Pathways for Escape using Rationally-Designed Anti-HIV-1 Antibodies. J Exp Med 210: 1235-49. PMCID: PMC3674693 doi:101084/jem20130221 Epub 2013 May 27

147. Parrish, NF, Gao, F, Li, H, Giorgi, EE, Barbian, HJ, Parrish, EH, Zajic, L, Iyer, SS, Decker, JM, Kumar, A, Hora, B, Berg, A, Cai, F, Hopper, J, Denny, TN, Ding, H, Ochsenbauer, C, Kappes, JC, Galimidi, RP, West, AP Jr, Bjorkman, PJ, Wilen, CB, Doms, RW, O'Brien, M, Bhardwaj, N, Borrow, P, Haynes, BF, Muldoon, M, Theiler, JP, Korber, B, Shaw, GM, Hahn, BH (2013) Phenotypic properties of transmitted founder HIV-1. Proc Natl Acad Sci USA 110: 6626-33. PMCID: PMC3637789 doi:101073/pnas1304288110

146. Klein, F, Diskin, R, Scheid, JF, Gaebler, C, Mouquet, H, Fu, BZ; Gnanapragasam, PNP, Seaman, MS, Bjorkman, PJ, Nussenzweig, MC (2013) Somatic mutations of the immunoglobulin framework are essential for broad and potent HIV neutralizing activit.y Cell 153: 126-38. PMCID: PMC3792590 doi:101016/jcell201303018

145. Scharf, L, West, AP, Gao, H, Lee, T, Scheid, JF, Nussenzweig, MC, Bjorkman, PJ, Diskin, R (2013) Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody. Proc Natl Acad Sci USA 110: 6049–54. PMCID: PMC3625305 doi:101073/pnas1303682110

2012

144. Mouquet H*, Scharf L*, Euler Z Liu Y, Eden C, Scheid JF, Halper-Stromberg A, Gnanapragasam PN, Spencer DI, Seaman MS, Schuitemaker H, Feizi T, Nussenzweig MC, Bjorkman PJ (2012) Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodie.s Proc Natl Acad Sci USA 109: E3268–E3277. PMCID: PMC3511153 doi:101073/pnas1217207109 (* these authors contributed equally to the work)

143. Klein F, Halper-Stromberg A, Horwitz JA, Gruell H, Scheid JF, Bournazos S, Mouquet H, Spatz LA, Diskin R, Abadir A, Zang T, Dorner M, Billerbeck E, Labitt RN, Gaebler C, Marcovecchio PM, Incesu RB, Eisenreich TR, Bieniasz PD, Seaman MS, Bjorkman PJ, Ravetch JV, Ploss A, Nussenzweig MC (2012) HIV therapy by a combination of broadly neutralizing antibodies in humanized mice. Nature 492: 118-122. doi:101038/nature11604

142. Pietzsch J, Gruell H, Bournazos S, Donovan BM, Klein F, Diskin R, Seaman MS, Bjorkman PJ, Ravetch JV, Ploss A, Nussenzweig MC (2012) A mouse model for HIV-1 entry. Proc Natl Acad Sci USA 109: 15859-64 Epub 2012 Sep 10. PMCID: PMC3465400 doi:101073/pnas1213409109

141. West AP Jr, Diskin R, Nussenzweig MC, Bjorkman PJ (2012) Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120. Proc Natl Acad Sci USA 109: E2083-90 Epub 2012 Jun 27. PMCID: PMC3409792 doi:101073/pnas1208984109

140. Ladinsky MS, Huey-Tubman KE, Bjorkman PJ (2012) Electron Tomography of Late Stages of FcRn-Mediated Antibody Transcytosis in Neonatal Rat Small Intestine. Mol Biol Cell 23: 2537-2545. PMCID: PMC3386217 doi:101091/mbcE12-02-0093

2011

139. Diskin, R, Scheid, JF, Marcovecchio, PM, West, AP, Jr, Klein, F, Gao, H, Gnanapragasam, PNP, Abadir, A, Seaman, MS, Nussenzweig, MC, Bjorkman PJ (2011) Increasing the potency and breadth of an HIV antibody by using structure-based rational design. Science 334: 1289-1293. PMCID: PMC323231 doi:101126/science1213782

138. West, AP, Jr, Galimidi, RP, Gnanapragasam, PNP, Bjorkman, PJ (2011) Single chain Fv-based anti-HIV proteins: Potential and Limitations. J Virol 86: 195-202. PMCID: PMC3255864 doi:101128/JVI05848-11

137. Bai, Y, Ye, L, Tesar, DB, Song, H, Zhao D, Bjorkman PJ, Roopenian DC, Zhu, X (2011) Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport. Proc Natl Acad Sci USA 108: 18406-18411. PMCID: PMC3215070 doi:101073/pnas1115348108

136. Keeffe, JR, Gnanapragasam, PNP, Gillespie, SK, Yong, J, Bjorkman, PJ, Mayo, SL (2011) Designed oligomers of cyanovirin show enhanced HIV neutralization. Proc Natl Acad Sci USA 108: 14079-14084. PMCID: PMC3161612 doi:101073/pnas1108777108

135. He, Y, Bjorkman, PJ (2011) Structure of FcRY, an avian immunoglobulin receptor related to mammalian mannose receptors, and its complex with IgY. Proc Natl Acad Sci USA 108: 12431–12436 .PMCID: PMC3145690 doi:101073/pnas1106925108

134. Scheid, JF, Mouquet, H Ueberheide, B, Diskin, R, Klein, F, Olivera, TY, Pietzsch, J, Fenyo, D, Abadir, A, Velinzon, K, Hurley, A, Myung, S, Boulad, F, Poignard, P, Burton, D, Pereyra, F, Ho, DD, Walker, BD, Seaman, MS, Bjorkman, PJ, Chait, BT, Nussenzweig, MC (2011) Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science 333: 1633-1637. doi:101126/science1207227

133. Luo XM, Lei MYY, Feidi RA, West AP Jr, Balazs AB, Bjorkman, PJ, Yang, L Baltimore D (2010) Dimeric 2G12 as a Potent Protection against HIV-1. PLoS Pathog 6(12): e1001225. PMCID: PMC3002980 doi:101371/journalppat1001225

132. Yang, F, West, AP, Jr, Bjorkman, PJ (2011) Crystal structure of a hemojuvelin-binding fragment of neogenin at 18 Å. J Struct Biol 174: 239-244. PMCID: PMC3074981 doi:101016/jjsb201010005

2010

131. Klein, JS*, Webster, A*, Gnanapragasam, PNP, Galimidi, RP, and Bjorkman, PJ (2010) A dimeric form of the HIV-1 antibody 2G12 elicits potent antibody-dependent cellular cytotoxicity. AIDS 24:1633-1640. PMCID: PMC2898891 doi:101097/QAD0b013e32833ad8c8 Erratum in: AIDS 2010 Oct 23;24(16):2601
(*these authors contributed equally to the work)

130. Jerdeva, GV, Tesar, DB, Huey-Tubman, KE, Ladinsky, MS, Fraser, SE, and Bjorkman, PJ (2010) Comparison of FcRn- and pIgR-mediated transport in MDCK cells by fluorescence confocal microscopy. Traffic 11: 1205-1220. PMCID: PMC2975666 doi:101111/j1600-0854201001083x

129. Klein, JS, Bjorkman, PJ (2010) Few and far between: how HIV may be evading antibody avidity. PLoS Pathogens 6(5): e1000908. PMCID: PMC2877745 doi:101371/journalppat1000908

128. Diskin, R, Marcovecchio, PM, Bjorkman, PJ (2010) Structure of a clade C HIV gp120 plus CD4 and a CD4-induced antibody reveals anti-CD4 polyreactivity. Nature Struct Mol Biol 17: 608-613. PMCID: PMC2949298 doi:101038/nsmb1796

127. Tesar, DB & Bjorkman, PJ (2010) An intracellular traffic jam: Fc receptor-mediated transport of Immunoglobulin G. Curr Opin Struct Biol 20: 1-8. PMCID: PMC2865255 doi:101016/jsbi201001010

126. Li, L, Fang, CJ, Ryan, JC, Niemi, EC, Lebrón, JA, Bjorkman, PJ, Arase, H, Torti, FM Torti, SV, Nakamura, MC, Seaman, WE (2010) Binding and uptake of H-ferritin is mediated by human transferrin receptor-1. Proc Natl Acad Sci USA 107: 3505-3510. PMCID: PMC2840523 doi:101073/pnas0913192107

125. West, AP, Jr, Galimidi, RP, Foglesong, CP, Gnanapragasam, PNP, Klein, JS, Bjorkman, PJ (2010) Evaluation of alternative CD4-CD4i antibody architectures yields potent, broadly cross-reactive anti-HIV reagents. J Virol 84: 261-269. PMCID: PMC2798438 doi:101128/JVI01528-09

2009

124. Yang, Z, West, AP, Jr, Bjorkman, PJ (2009) Crystal structure of TNFalpha complexed with a poxvirus MHC-related TNF binding protein. Nature Struct Mol Biol 16: 1189-1191. PMCID: PMC2819277 doi:101038/nsmb1683

123. *He, Y, Jensen, GJ, Bjorkman, PJ (2009) Nanogold as a specific marker for electron cryotomography. Microscopy and Microanalysis 15: 183-188. PMCID: PMC2785728
doi:101017/S1431927609090424

*Selected as the best Biological Sciences paper in Microscopy and Microanalysis in 2009

122. Klein, JS, Gnanapragsam, PNP, Galimidi, RP, West, AP, Jr, Bjorkman, PJ (2009) Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10. Proc Natl Acad Sci USA 106: 7385-7390. PMCID: PMC2678646 doi:101073/pnas0811427106

121. He, Y, Jensen, GJ, Bjorkman, PJ (2009) Cryoelectron tomography of homophilic adhesion mediated by the neural cell adhesion molecule L1. Structure 17: 460-471. PMCID: PMC2744468 doi:101016/jstr200901009

120. Rice, AE, Mendez, MJ, Hokanson, CA, Rees, DC, Bjorkman, PJ (2009) Investigation of the biophysical and cell biological properties of ferroportin, a multi-pass integral membrane protein iron exporter. J Mol Biol 386: 717-732. PMCID: PMC2677177 doi:101016/jjmb200812063

119. West, AP, Jr, Galimidi, RP, Foglesong, CP, Gnanapragasam, PNP, Huey-Tubman, KE, Klein, JS, Suzuki, M, Tiangco, NE, Vielmetter, J, Bjorkman, PJ (2009) Design and expression of a dimeric form of the anti-HIV antibody 2G12 with increased neutralization potency. J Virology 83: 98-104. PMCID: PMC2612297 doi:101128/JVI01564-08

2008

118. He, W, Ladinsky, MS, Huey-Tubman KE, Jensen, GJ, McIntosh, JR, Bjorkman, PJ (2008) FcRn-mediated antibody transport across epithelial cells revealed by electron tomography. Nature 455: 542-546. PMCID: PMC2773227 doi:101038/nature07255

117. Arnon, TI, Kaiser, JT, West, AP Jr, Olson, R, Diskin, R, Viertlboeck, BC, Gobel, TW, Bjorkman, PJ (2008) The crystal structure of CHIR-AB1, a primordial avian classical Fc receptor. J Mol Biol 381: 1012-1024. PMCID: PMC2603183 doi:101016/jjmb200806082

116. Zhang, A-S, Yang, F, Meyer, K, Hernandez, C, Chapman-Arvedon, T, Bjorkman, PJ, Enns, CA (2008) Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane. J Biol Chem 283: 17494-17502. PMCID: PMC2427329 doi:101074/jbcM710527200

115. Morphew, M, He, W, Bjorkman, P J, and McIntosh, J R (2008) Silver enhancement of nanogold particles during freeze substitution fixation for electron microscopy. J Microscopy 230: 263-267. PMCID: PMC2722379 doi:101111/j1365-2818200801983x

114. Yang, Z and Bjorkman, PJ (2008) Structure of UL18, a Peptide-Binding Viral MHC Mimic, Bound to a Host Inhibitory Recepto.r Proc Natl Acad Sci USA 105: 10095-10100. PMCID: PMC2465803 doi:101073/pnas0804551105

113. Schmidt, PJ, Toran, PT, Giannetti, AM Bjorkman, PJ, Andrews, NC (2008) The transferrin receptor modulates HFE-dependent regulation of hepcidin expression. Cell Metabolism 7: 205-214. PMCID: PMC2292811 doi:101016/jcmet200711016

112. Yang, F, West, AP, Jr, Allendorph, G, Choe, S, Bjorkman, PJ (2008) Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains. Biochemistry 47: 4237-4245. PMCID: PMC2819367 doi:101021/bi800036h

111. Tesar, DB, Cheung, EJ, and Bjorkman, PJ (2008) The chicken yolk sac IgY receptor, a mammalian mannose receptor family member, transcytoses IgY across polarized epithelial cells. Mol Biol of the Cell 19: 1587-1593. PMCID: PMC2291411 doi:101091/mbcE07-09-0972

110. Sprague, ER, Reinhard, H, Cheung, EJ, Farley, AH, Trujillo, RD, Hengel, H, Bjorkman, PJ (2008) The human cytomegalovirus Fc receptor gp68 binds the Fc CH2-CH3 interface of IgG. J Virology 82: 3490-3499. PMCID: PMC2268481 doi:101128/JVI01476-07

2007

109. He, W, Kivork, C, Machinani, S Morphew, MK, Gail, AM, Tesar, DB, Tiangco, NE, McIntosh, JM, Bjorkman, PJ (2007) A freeze substitution fixation-based gold enlarging technique for EM studies of endocytosed nanogold-labeled molecules. J Struct Biol 160: 103-113. PMCID: PMC2076746 doi:101016/jjsb200707004

108. Ja, WW, West, AP Jr, Delker, SL, Bjorkman, PJ, Benzer, S, Roberts, RW (2007) Extension of Drosophila lifespan with a G protein-coupled receptor inhibitor. Nature Chemical Biology 3: 415-419. PMCID: PMC2803097 doi:101038/nchembio20072

107. Li, P, Huey Tubman, KE, Gao, T, Li, X, West, AP Jr, Bennett, MJ, Bjorkman, PJ (2007) The structure of a poly-Gln/anti-poly-Gln complex reveals binding according to a linear lattice model. Nature Structural & Molecular Biology 14: 381-387. doi:101038/nsmb1234

2006

106. Bjorkman, PJ (2006) Finding the groove. Nature Immunology 7: 787-789. doi:101038/ni0806-787

105. Tesar, DB, Tiangco, NE, Bjorkman, PJ (2006) Ligand valency affects FcRn-mediated transcytosis, recycling, and intracellular trafficking Traffic 7: 1-16. doi:101111/j1600-0854200600457x

104. Olson, R, Dulac, C, Bjorkman, PJ (2006) MHC homologs in the nervous system - They haven't lost their groove Curr Opin Neurobiology 16: 351-357. doi:101016/jconb200605007

103. Hamburger, AE, Bjorkman, PJ, Herr, AB (2006) Structural insights into antibody-mediated mucosal immunity Current Topics in Microbiology and Immmunology 308:173-204. dio:101007/3-540-30657-9_8

102. Sprague, ER, Wang, C, Baker, D, Bjorkman, PJ (2006) Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging. Public Library of Science (PLoS): Biology 4: 525-536. doi:101371/journalpbio0040148

101. Kacskovics, I, Kis, Z, Mayer, B, West, AP, Tiangco, NE, Tilahun, M, Cervenak, L, Bjorkman, PJ, Goldsby, RA, Szenci, O, and Hammarström, L (2006) FcRn mediates elongated serum half-life of human IgG in the cattle. International Immunology 18: 525-536. doi:101093/intimm/dxh393

100. McDermott, LC, Freel, JA, West, AP, Bjorkman, PJ, and Kennedy, MW (2006) Zn-Alpha2-glycoprotein, an MHC Class I-Related Glycoprotein Regulator of Adipose Tissues: Modification or Abrogation of Ligand Binding by Site-Directed Mutagenesis. Biochemistry Published on Web, January 16, 2006. doi:101021/bi051881v

2005

99. Giannetti AM, Halbrooks PJ, Mason AB, Vogt TM, Enns CA, Bjorkman PJ (2005) The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin. Structure 13:1613-23. doi:101016/jstr200507016

98. Zhang AS, West AP Jr, Wyman AE, Bjorkman PJ, Enns CA (2005) Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells. J Biol Chem 280:33885-94. doi:101074/jbcM506207200

97. Halbrooks PJ, Giannetti AM, Klein JS, Bjorkman PJ, Larouche JR, Smith VC, MacGillivray RT, Everse SJ, Mason AB (2005) Composition of pH-sensitive triad in C-lobe of human serum transferrin Comparison to sequences of ovotransferrin and lactoferrin provides insight into functional differences in iron release. Biochemistry 44: 15451-15460. doi:101021/bi0518693

96. Olson, R, Huey-Tubman, KE, Dulac, C, and Bjorkman, PJ (2005) Structure of a Pheromone Receptor-Associated MHC Molecule with an Open and Empty Groove. Public Library of Science: Biology 3:1436-1448. doi:101371/journalpbio0030257

95. Hamburger, AE, West Jr, AP, Hamburger, ZA, Hamburger,P, Bjorkman, PJ (2005) Crystal structure of a secreted insect ferritin reveals a symmetrical arrangement of heavy and light chains. J Mol Biol 349:558-569. doiorg/doi:101016/jjmb200503074

94. Davis, MI, Bennett, MJ, Thomas, LM, and Bjorkman, PJ (2005) Crystal structure of prostate-specific memb rane antigen, a tumor marker and peptidase. Proc Natl Acad Sci USA 102:5981-5986. doi 101073/pnas0502101102

93. Luo, R, Mann, B, Lewis, WS, Rowe, A, Heath, R Stewart, ML, Hamburger, AE, Sivakolundu, S, Lacy, ER, Bjorkman, PJ, Tuomanen, E, Kriwacki, RW (2005) Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae. EMBO J 24:34-43. doi:101038/sjemboj7600490

2004

92. Hamburger, AE, West, AP, Jr, Bjorkman, PJ (2004) Crystal structure of a polymeric immunoglobulin-binding fragment of the human polymeric immunoglobulin receptor. Structure 12:1925-1935. doi:101016/jstr200409006

91. Delker, SL, West, AP, Jr, McDermott, L, Kennedy, MW, Bjorkman, PJ (2004) Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein. J Struct Biol 148:205-213. doi:101016/jjsb200404009

90. Giannetti AM, and Bjorkman, PJ (2004) HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface. J Biol Chem 279:25866-25875. doi:101074/jbcM401467200

89. West, AP, Jr, Herr, AB, and Bjorkman, PJ (2004) The chicken yolk sac IgY receptor, a functional equivalent of the mammalian MHC-related Fc receptor, is a phospholipase A2 receptor homolog. Immunity 20:601-610. doi:101016/S1074-7613(04)00113-X

88. Sprague, ER, Martin, WL, Bjorkman, PJ (2004) pH-dependence and stoichiometry of binding to the Fc region of IgG by the herpes simplex virus Fc receptor gE-gI. J Biol Chem 279:14184-14193. doi:101074/jbcM313281200.

2003

8.7. Giannetti AM, Snow, PM, Zak, O, and Bjorkman, PJ (2003) Mechanism for Multiple Ligand Recognition by the Human Transferrin Receptor. Public Library of Science: Biology 1:341-350. doi:101371/journalpbio0000051

86. Willcox, BE, Thomas, LE, Bjorkman, PJ (2003) Crystal structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor. Nat Immunol 4:913-919. doi:101038/ni961

85. Herr, AB, Ballister, ER, Bjorkman, PJ (2003) Insights into IgA-mediated immune responses from the crystal structures of human FcaRI and its complex with IgA1-Fc. Nature 423:614-620. doi:101038/nature01685

84. Herr, AB, White, CL, Milburn, C, Wu, C, & Bjorkman, PJ (2003) Bivalent binding of IgA1 to FcaRI suggests a mechanism for cytokine activation of IgA phagocytosis. J Mol Biol 327:645-657. doi:101016/S0022-2836(03)00149-9

83. Vogt, TM, Blackwell, AD, Giannetti, AM, West, AP, Jr, Bjorkman, PJ, Enns, CA (2003) Heterotypic interactions between TfR2 and TfR. Blood 101: 2008-2014. doi:101182/blood-2002-09-2742

2002

82. Willcox BE, Thomas LM, Chapman, TL, Heikema AP, West Jr, AP, Bjorkman PJ (2002) Crystal Structure of LIR-2 (ILT4) at 18Å: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18. BioMedCentral Structural Biology 2: 1-9. doi:101186/1472-6807-2-6

81. Bennett, MJ, Huey-Tubman, KE, Herr, AB, West, AP, Jr, Ross, SA, Bjorkman, PJ (2002) A linear lattice model for polyglutamine in CAG expansion diseases. Proc Natl Acad Sci USA 99:11634-11639. doi:101073/pnas182393899

2001

80. West, AP, Jr, Giannetti, AM, Herr, AB, Bennett, MJ, Nangiana, JS, Pierce, JR, Snow, PM, and Bjorkman, PJ (2001) Mutational Analysis of the Transferrin Receptor Reveals Overlapping HFE and Transferrin Binding Sites. J Mol Biol 313: 385-397. doi:101006/jmbi20015048

79. Kennedy, MW, Heikema, AP, Cooper, A, Bjorkman, PJ, and Sanchez, LM (2001) Hydrophobic ligand binding by ZAG, a soluble fat-depleting factor related to class I MHC proteins. J Biol Chem 276: 35008-35013. doi:101074/jbcC100301200

78. O'Callaghan, CA, Cerwenka, A, Willcox, BE, Lanier, LL, and Bjorkman, PJ (2001) Molecular Competition for NKG2D: H60 and RAE1 Compete Unequally for NKG2D with Dominance of H60. Immunity 15: 201-211. doi:101016/S1074-7613(01)00187-X

77. Martin, WL, West, Jr, AP, Gan, L, Bjorkman, PJ (2001) Crystal structure at 28 Å of an FcRn/heterodimeric Fc complex: mechanism of pH dependent binding. Molecular Cell 7: 867-877. doi:101016/S1097-2765(01)00230-1

76. West, AP, Llamas, LL, Snow, PM Benzer, S, and Bjorkman, PJ (2001) Crystal structure of the ectodomain of methuselah: A Drosophila G protein-coupled receptor associated with extended life-span. Proc Natl Acad Sci, USA 98: 3744-3749. doi:101073/pnas051625298

75. Liu, Y, Misulovin, Z, and Bjorkman, PJ (2001) The molecular mechanism of sulfated carbohydrate recognition by the cysteine-rich domain of mannose receptor. J Mol Biol 305: 481-490. doi:101006/jmbi20004326

2000

74. West, AP, Bennett, MJ, Sellers, VM, Andrews, NC, Enns, CA, Bjorkman PJ (2000) Comparisons of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem 275: 38135-38138. doi:101074/jbcC000664200

73. Chapman, TL, Heikema, AP, West, AP, and Bjorkman, PJ (2000) Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2). Immunity 13:727-736. doi:101016/S1074-7613(00)00071-6

72. West, AP Bjorkman, PJ (2000) Crystal structure and immunoglobulin G binding properties of the human MHC-related Fc receptor. Biochemistry 39: 9698-9708. doi:101021/bi000749m

71. Liu, Y, Chirino, AJ, Leteux, C, Feizi, T, Misulovin, Z, Nussenzweig, MC, Bjorkman, PJ (2000) Crystal Structure of the Cysteine Rich Domain of Mannose Receptor Complexed with a Sulfated Carbohydrate Ligand. J Exp Med 191: 1105-1116 Published online Mar 27 2000. doi:101084/jem19171105
70. Bennett, MJ, Lebrón, JA & Bjorkman, PJ (2000) Crystal structure of the hereditary hemochromatosis protein HFE complexed with transferrin receptor. Nature 403: 46-53. doi:101038/47417
1999

69. Lebrón, JA, West, AP, Bjorkman, PJ (1999) The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor. J Mol Biol 294: 239-245. doi:org/101006/jmbi19993252.

68. Chapman, TL, Heikema, AP & Bjorkman, PJ (1999) The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral MHC homolog UL18. Immunity 11: 603-613. doi:org/101016/S1074-7613(00)80135-1

67. Martin, WL & Bjorkman, PJ (1999) Characterization of the 2:1 complex between the class I MHC-related Fc receptor and its Fc ligand in solution. Biochemistry 38: 12639-12647.

66. Hamburger, ZA, Brown, MS, Isberg, RR & Bjorkman, PJ (1999) Crystal structure of invasin: a bacterial integrin-binding protein. Science 286: 291-295.

65. Hanke, T, Takizawa, H McMahon, CW, Busch, DH, Pamer, EG, Miller, JD, Altman, JD, Liu, Y, Cado, D, Lemonnier, FA, Bjorkman, PJ, & Raulet, DH (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11, 67-77.

64. Sánchez, LM, Penny, DM & Bjorkman, PJ (1999) Stoichiometry of the interaction between the MHC-related Fc receptor and its Fc ligand. Biochemistry 38: 9471-9476.

63. Lebrón, JA & Bjorkman, PJ (1999) The Transferrin Receptor Binding Site on HFE, the Class I MHC-Related Protein Mutated in Hereditary Hemochromatosis. J Mol Biol 289: 1109-1118.

62. Sánchez, LM*, Chirino, AJ* & Bjorkman, PJ (1999) Crystal structure of human Zn-alpha2-glycoprotein: a fat-depleting factor related to MHC molecules. Science 283: 1914-1919 (* these authors contributed equally to the work).

61. Chapman, TL, You, I, Joseph, IM, Bjorkman, PJ, Morrison, SL & Raghavan, M (1999) Characterization of the interaction between the herpes simplex virus type I Fc receptor and Immunoglobulin G. J Biol Chem 274: 6911-6919.

60. Lebrón, JA, Shen, H, Bjorkman, PJ, & Ou, S (1999) Tolerization of adult mice to immunodominant proteins before monoclonal antibody production. J Immunol Meth 222/1-2: 59-63.

1998

59. Su, X-D, Gastinel, LN, Vaughn, DE, Faye, I, Poon, P, & Bjorkman, PJ (1998) Crystal structure of hemolin: A horseshoe shape with implications for homophilic adhesion. Science 281: 991-995.

58. Lebrón, JA*, Bennett, MJ*, Vaughn, DE, Chirino, AJ, Snow, PM, Mintier, GA, Feder, JN, & Bjorkman, PJ (1998) Crystal Structure of the Hemochromatosis Protein HFE and Characterization of its Interaction with Transferrin Receptor. Cell 93:111-123 (* these authors contributed equally to the work).

57. Feder, JN, Penny, DM, Irrinke, A, Lee, VK, Lebrón, JA, Watson, N, Tsuchihashi, Z, Sigal, E, Bjorkman, PJ & Schatzman, RC (1998) The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA 95: 1472-1477.

56. Weng, Z, Gulukota, K, Vaughn, DE, Bjorkman, PJ, and DeLisi, C (1998) Computational determination of the structure of rat Fc bound to the neonatal Fc receptor. J Mol Biol 282: 217-225.

55. Leong, CC, Chapman, TL, Bjorkman, PJ, Formankova, D, Mocarski, ES, Phillips, JH, & Lanier, LL (1998) Modulation of natural killer cell cytotoxicity in human cytomegalovirus infection: The role of endogenous class I MHC and a viral class I homolog. J Exp Med 187: 1681-1687.

54. Wilson, IA & Bjorkman, PJ (1998) Unusual MHC-like molecules: CD1, Fc receptor, the hemochromatosis gene product, and viral homologs. Curr Opin in Immunol 10: 67-73.

53. Vaughn, DE & Bjorkman, PJ (1998) Structural basis of pH dependent antibody binding by the neonatal Fc receptor. Structure 6: 63-73.

52. Chapman, TL and Bjorkman, PJ (1998) Characterization of a murine cytomegalovirus class I MHC homolog: Comparison to MHC molecules and to the human cytomegalovirus MHC homolog. J Virol 72: 460-466.

1997

51. Vaughn, DE, Milburn, CM, Penny, DM, Martin, WLM, Johnson, JL and Bjorkman, PJ (1997) Identification of critical IgG binding epitopes on the neonatal Fc receptor. J Mol Biol 274: 597-607.

50. West, AP, Bjorkman, PJ, Dougherty, DA and Lester, HA (1997) Expression and circular dichroism studies of the extracellular domain of the a subunit of the nicotinic acetylcholine receptor. J Biol Chem 272: 25468-25473.

49. Vaughn, DE and Bjorkman, PJ (1997) High affinity binding of the neonatal Fc receptor to its IgG ligand requires receptor immobilization. Biochemistry 36: 9374-9380.

48. Morgan, CS, Holton, JM, Olafson, BD, Bjorkman, PJ, Mayo, SL (1997) Circular dichroism determination of class I MHC-peptide equilibrium dissociation constants. Protein Science 6: 1771-1773.

47. Bjorkman, PJ (1997) MHC restriction in three dimensions: A view of T cell receptor/ligand interactions. Cell 89: 167-170.

46. Sánchez, LM, López-Otín, C, and Bjorkman, PJ (1997) Biochemical characterization and crystallization of human Zn-alpha2-glycoprotein, a soluble class I MHC homolog. Proc Natl Acad Sci USA 94: 4626-4630.

1996

45. Gakamsky, D, PJ Bjorkman, and I Pecht (1996) Peptide Interaction with a class I major histocompatibility complex-encoded molecule: Allosteric control of the ternary complex stability. Biochemistry 35: 14841-14848.

44. Raghavan, M, JA Lébrón, JL Johnson, and PJ Bjorkman (1996) Extended repertoire of permissible peptide ligands for HLA-B*2702. Protein Science 5: 2080-2088.

43. Raghavan, M and PJ Bjorkman (1996) Fc receptors and their interactions with immunoglobulins. Ann Rev Cell Dev Biol 12: 181-220.

42. Vaughn, DE and PJ Bjorkman (1996) The (Greek) Key to structures of neural adhesion molecules. Neuron 16: 261-273.

1995

41. Raghavan, M, VR Bonagura, SL Morrison, and PJ Bjorkman (1995) Analysis of the pH dependence of neonatal Fc receptor/Immunoglobulin G interaction using antibody and receptor variants. Biochemistry 34: 14649-14657.

40. Fahnestock, ML, JL Johnson, RMR Feldman, JM Neveu, WS Lane, and PJ Bjorkman (1995) The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides. Immunity 3: 583-590.

39. Raghavan, M, Y Wang, and PJ Bjorkman (1995) Effects of Receptor Dimerization on the Interaction between the class I MHC-related Fc Receptor and Immunoglobulin G. Proc Natl Acad Sci USA 92: 11200-11204.

38. Raghavan, Mand PJ Bjorkman (1995) BIAcore: A microchip-based system for analyzing the formation of macromolecular complexes. Structure 3: 331-333.

1994

37. Bjorkman, PJ and WP Burmeister (1994) Structure of two classes of MHC molecules elucidated: Crucial differences and similarities. Curr Opin in Struct Biol 4: 852-856.

36. Burmeister, WP, AH Huber, and PJ Bjorkman (1994) Crystal structure of the complex of rat neonatal Fc receptor with Fc. Nature 372: 379-383.

35. Burmeister, WP, LN Gastinel, NE Simister, ML Blum, and PJ Bjorkman (1994) Crystal structure at 2.2 Å resolution of the rat neonatal Fc receptor. Nature 372: 336-343.

34. Strong, RK, DM Penny, RMR Feldman, LP Weiner, JJ Boniface, MM Davis, and PJ Bjorkman (1994) Engineering and expression of a secreted murine T cell receptor with reduced N-linked glycosylation. J Immunol 153: 4111-4121.

33. Strong, RK, D Vaughn, PJ Bjorkman, and PM Snow (1994) Expression and crystallization of the extracellular domains of Drosophila fasciclin III. J Mol Biol 241: 483-487.

32. Raghavan, M, LN Gastinel, MY Chen, and PJ Bjorkman (1994) Investigation of the interaction between the class I MHC-related Fc receptor and its immunoglobulin G ligand. Immunity 1: 303-315.

31. Fahnestock, ML, JL Johnson, RMR Feldman, TJ Tsomides, J Mayer, L Narhi and PJ Bjorkman (1994) The effects of peptide length and composition on binding to an empty class I MHC heterodimer. Biochemistry 33: 8149-8158.

30. Huber, AH, Y-ME Wang, AJ Bieber and PJ Bjorkman (1994) Crystal structure of tandem type III fibronectin domains from Drosophila neuroglian at 2.1 Å. Neuron 12: 717-731.

29. Fahnestock, ML, M McMillan, JM Dadgari and PJ Bjorkman (1994) Phosphatidyl inositol linked forms of a murine class I MHC molecule expressed on CHO cells retain peptide binding capability and alloreactivity International. Immunology 6: 307-314.

1993

28. Raghavan, M, LN Gastinel and PJ Bjorkman (1993) The class I major histocompatibility complex related Fc receptor shows pH-dependent stability differences correlating with immunoglobulin binding and release. Biochemistry 32: 8654-8660.

27. Bjorkman, PJ and DC Wiley (1993) The human class I histocompatibility antigen, HLA-A2. Structure 1: xiv-xv.

26. Huber, AH, LN Gastinel, RF Kelly and PJ Bjorkman (1993) Crystallization and stoichiometry of binding of a complex between a rat intestinal Fc receptor and Fc. J Mol Biol 230: 1077-1083.

25. Wang, W-C, K Zinn and PJ Bjorkman (1993) Expression, structural and functional studies of fasciclin I, an insect cell adhesion molecule. J Biol Chem 268: 1448-1455.

1992

24. Fahnestock, ML, I Tamir, L Narhi and PJ Bjorkman (1992) Thermal stability comparison of purified empty and peptide filled forms of a class I MHC molecule. Science 258: 1658-1662.

23. Gastinel, LN, NE Simister and PJ Bjorkman (1992) Expression and crystallization of a soluble and functional form of an Fc receptor related to class I MHC molecules. Proc Natl Acad Sci USA 89: 638-642.

1991

22. Devaux, B, PJ Bjorkman, C Stevenson, W Greif, JF Elliott, C Sagerstrom, C Clayberger, AM Krensky and MM Davis (1991) Generation of monoclonal antibodies against soluble human T cell receptor polypeptides. Eur J Immunology 21: 2111-2119.

21. Saper, MA, PJ Bjorkman and DC Wiley (1991) Refined structure of the human histocompatibility antigen HLA-A2 at 26Å resolution. J Mol Biol 219: 277-319.

1990

20. Chamow, SM, DH Peers, RA Byrn, MG Mulkerrin, RJ Harris, W-C Wang, PJ Bjorkman, DJ Capon and A Ashkenazi (1990) Enzymatic cleavage of an immunoadhesin generates crystallizable, Fd-like fragments of an immunoglobulin gene superfamily member, CD4. Biochemistry 29: 9885-9891.

19. Davis, MM, B F de St Groth, LJ Berg, A Lin, B Devaux, C Sagerstrom, JF Elliott and PJ Bjorkman (1990) Selection of an ab T-cell antigen receptor in vivo and expression in vitro in a soluble form. In Current Topics in Membranes and Transport, 36: 155-159, 1990.

18. Bjorkman, PJ and MM Davis (1990) Structure of a human histocompatibility molecule: Implications for its interactions with peptides and T cell receptors. In Use of X-ray Crystallography in the Design of Antiviral Agents, (eds W Graeme Laver and Gillian M Air) pp 19-34.

17. Bjorkman, PJand P Parham (1990) Structure, function and diversity of class I major histocompatibility complex molecules. Ann Rev Biochem 90: 253-88.

1989

16. Garrett, TPJ, MA Saper, B Samraoui, PJ Bjorkman and D CWiley (1989) Structure/function studies of major histocompatibility antigens. Transplantation Proceedings 21:l, 588-590.

15. Davis, MM, BF de St Groth, A Lin, B Devaux, C Sagerström, JF Elliott, and PJ Bjorkman (1989) Selection of an ab T cell antigen receptor in vivo and engineering a solulizable form In the Proceedings of the 7th International Congress of Immunology, Progress in Immunology VII, pp 16-21.

14. Davis, MM, LJ Berg, AY Lin, B F de St Groth, B Devaux, CG Sagerström, PJ Bjorkman, JF Elliott (1989) TCR recognition and Selection in vivo. In Symposium on Immunological Recognition (Proceedings) Cold Spring Harbor Lab Press, pp 119-128.

13. Bjorkman, PJ and MM Davis (1989) A model for the interaction of a T cell receptor with a peptide-MHC complex. In Symposium on Immunological Recognition (Proceedings) Cold Spring Harbor Lab Press, pp 365-373.

12. Garrett, TPJ, MA Saper, PJ Bjorkman, JL Strominger and DCWiley (1989) Specificity pockets for the side chains of peptide antigens in HLA-Aw68. Nature 342: 692-9.6

11. Madden, D, M ASaper, TPJ Garrett, PJ Bjorkman, JL Strominger, and DC Wiley (1989) A comparison of orthorhombic and monoclinic crystal structures of HLA-A2. In Symposium on Immunological Recognition (Proceedings) Cold Spring Harbor Lab Press p 353-359.

1988

10. Bjorkman, PJ, WS Bennett and DC Wiley (1988) Data collection from very thin HLA crystals using synchrotron radiation. In Proceedings of Brookhaven Symposium in Biology No 35 on Synchrotron Radiation in Structural Biology, Plenum Publishing Corporation, New York, NY, p 123-131.

9. Saper, MA, PJ Bjorkman and DC Wiley (1988) Iterative molecular averaging and phase refinement of two HLA-A2 crystal forms. In Proceedings of the Daresbury Study Weekend , 5-6 February, (eds S Phillips, E Dodson, and S Bailey), Science and Engineering Research Council, pp 39-48.

8. Davis, MM and PJ Bjorkman (1988) T cell antigen receptor genes and T cell recognition. Nature 334: 395-402.

7. Brown, JH, T Jardetsky, MA Saper, B Samraoui, PJ Bjorkman and DC Wiley (1988) A hypothetical model of the foreign antigen binding site of class II histocompatibility antigens. Nature 332: 845-850.

1987

6. Bjorkman, PJ, MA Saper, B Samraoui, WS Bennett, JL Strominger and DC Wiley (1987) The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329: 512-518.

5. Bjorkman, PJ, MA Saper, B Samraoui, WS Bennett, JL Strominger and DC Wiley (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329: 506-512.

1985

4. Bjorkman, PJ, JL Strominger and DC Wiley (1985) Crystallization and x-ray diffraction studies on the histocompatibility antigens HLA-A2 and HLA-A28 from human cell membranes. J Mol Biol 186: 205-210.

1984

3. Bjorkman, PJ Crystallographic studies of HLA. PhD Thesis, Harvard University, June, l984.

1979

2. Lee, TD, GB Birrell, PJ Bjorkman and JFW Keana (1979) Azethoxyl Nitroxide Spin Labels: ESR studies involving thiourea crystals, model membrane systems and chromatophores, and chemical reduction with ascorbate and dithiothreitol. Biochim Biophys Acta 550: 369-383.

1976

1. Bjorkman, PJ and LB Church (1976) Comparison of zinc/copper ratios in tissues of a control group versus victims of atheroschlerotic heart disease. Proc Oregon Acad Sciences 78.