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California Institute of Technology
Division of Biology and Biological Engineering
MC 114-96 | 1200 E. California Blvd.,
Pasadena, CA 91125
(626) 395-8351 phone
murphym [at] caltech dot edu
Our laboratory is interested in immune recognition of viral pathogens. We are investigating the immune responses against HIV-1 and other viruses, most recently SARS-CoV-2, in order to develop improved therapeutics and/or vaccines. We use X-ray crystallography, electron microscopy, and biochemistry to study pathogen glycoproteins and host immune proteins. Using structural information and alternate antibody architectures, we are engineering antibody-based reagents with increased potency and breadth. We are also investigating the structural correlates of potent antibody-mediated neutralization of HIV-1, SARS-CoV-2, and hepatitis C virus to better understand what leads to naturally-occurring potent neutralizing antibodies.
Anthony West has developed Variant Database, a SARS-CoV-2 mutation pattern query tool, 06/2021
HIVRADP01 2019 Project:
Developing Immunogens to Elicit Broadly Neutralizing anti-HIV-1Antibodies- 2021 Pearl Meister Greengard Prize: Pamela Bjorkman
- Webinar: Pamela Bjorkman: Viruses, Antiviral
and Vaccines, 04/2020- The HIV Life Cycle
–Donate in memory of Will Lange, 2016
–Earnest C. Watson Lecture, 2015
–TEDxCaltech: New Anti-HIV Agents, 2013
–Traveling with Purpose - Volunteering in India, 2012
–World AIDS Day - News Conf on KNBC-TV, 2012
–LA Theatre Works: Rosalind Franklin, 2011
–Rachel Galimidi wins Clauser Doctoral Prize, 2016
–Louise Scharf, AIDS Vaccine Barcelona, 2013
–Gwen Owens, Crystals in space, 2013
–Gwen Owens in CASIS video, 2013
@bjorkmanlab