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Our laboratory is interested in immune recognition of viral pathogens. We are particularly interested in understanding the immune response against HIV-1 and influenza in order to develop improved therapeutics. We use X-ray crystallography, electron microscopy, and biochemistry to study pathogen envelope glycoproteins and host immune response proteins. Using structural information and alternate antibody architectures, we are engineering antibody-based reagents with increased potency and breadth. We are also investigating the structural correlates of broad and potent antibody-mediated neutralization of HIV-1 to better understand what leads to naturally-occurring broad and potent antibodies. In related work, we use 3D imaging techniques such as electron tomography and fluorescent microscopy to investigate HIV/SIV infection in animal and human tissues.

Earnest C. Watson Lecture, 2015
TEDxCaltech: Visualizing and Engineering
New Anti-HIV Agents, 2013

Traveling with Purpose - Volunteering in India, 2012
World AIDS Day - News Conference on KNBC-TV, 2012
LA Theatre Works interview about
Rosalind Franklin with Pamela Bjorkman, 2011


–Louise Scharf’s talk at AIDS Vaccine, 2013
–Crystals in space - interview with
graduate student Gwen Owen, 2013


HIVRAD P01 Project - Development, Structure, and Function of Broadly Neutralizing anti-HIV Antibodies



California Institute of Technology
Division of Biology and Biological Engineering
MC 114-96 | 1200 E. California Blvd.,
Pasadena, CA 91125
(626) 395-8351 phone | 626) 792-3683 fax
murphym [at] caltech dot edu