Our laboratory is interested in protein-protein interactions, particularly those mediating immune recognition. We use X-ray crystallography and biochemistry to study purified proteins, and electron and confocal microscopy to examine protein complexes in cells. Some of our work focuses upon homologs and mimics of class I major histocompatibility complex (MHC) proteins, which normally function in peptide presentation to T cells. MHC homologs have similar three-dimensional structures, but different functions including immune functions (IgG transport by the neonatal Fc receptor, FcRn; evasion of the immune response by viral MHC mimics), and non-immune functions (regulation of iron or lipid metabolism by HFE and ZAG). We focus on three interrelated areas: (1) structure/function studies of homologs and mimics of MHC proteins; (2) cell biological studies of antibody receptors, for example, the MHC-related neonatal Fc receptor; and (3) designing antibodies with increased efficacy against HIV.
TEDxCaltech: Visualizing and Engineering New Anti-HIV Agents
Traveling with Purpose - Volunteering in India
World AIDS Day - News Conference on KNBC-TV
HIVRAD P01 Project - Development, Structure, and Function of Broadly Neutralizing anti-HIV Antibodies
Crystals in space - interview with graduate student Gwen Owens
Louise Scharf’s talk at AIDS Vaccine, 2013
LA Theatre Works interview about Rosalind Franklin with Pamela Bjorkman
Hughes Medical Institute
Division of Biology and Biological Engineering, 114-96
California Institute of Technology
1200 E. California Blvd.
Pasadena, CA 91125
(626) 395-8351 phone
626) 792-3683 fax
murphym [at] caltech dot edu