The Bjorkman Group at Caltech


BJÖRKPeople BJÖRKLab Information BJÖRKTeaching BJ Ö RKPublications BJÖRKStructures BJÖRK Protocols Plasmid requests (Addgene) Lab mAbs & other reagents Safety \| Lab stuff Instrument sign-up calendar Bjorklab ordering STRUCTURAL BIOLOGY RELATED GROUPS Clemons Lab \| Hoelz Lab Jensen Lab \| Mayo Lab \| Rees Lab Molecular Observatory SSRL beamtime/Crystal trays Protein Expression Center WEBSITES OF INTEREST Caltech Biological Imaging Center Rosen Bioengineering Center External fellowships for grad student Fellowships Resources for postdocs Integrated structural biology platforms History of Crystallography WebofScience \| CITLibrary \| PubMed CITdirectory \| CITaccess BBE Seminars CRYSTALLOGRAPHY RESOURCES	Our laboratory is interested in immune recognition of viral pathogens. We are particularly interested in understanding the immune response against HIV-1 and influenza in order to develop improved therapeutics. We use X-ray crystallography, electron microscopy, and biochemistry to study pathogen envelope glycoproteins and host immune response proteins. Using structural information and alternate antibody architectures, we are engineering antibody-based reagents with increased potency and breadth. We are also investigating the structural correlates of broad and potent antibody-mediated neutralization of HIV-1 to better understand what leads to naturally-occurring broad and potent antibodies. In related work, we use 3D imaging techniques such as electron tomography and fluorescent microscopy to investigate HIV/SIV infection in animal and human tissues. - Donate to Udayan orphanage in memory of Will Lange, 2016 –Earnest C. Watson Lecture, 2015 –TEDxCaltech: Visualizing and Engineering New Anti-HIV Agents, 2013 –Traveling with Purpose - Volunteering in India, 2012 –World AIDS Day - News Conf on KNBC-TV, 2012 –LA Theatre Works: Rosalind Franklin, 2011 -Rachel Galimidi wins Clauser Doctoral Prize, 2016 –Louise Scharf, AIDS Vaccine Barcelona, 2013 - Gwen Owens, Crystals in space, 2013 - Gwen Owens in CASIS video, 2013 HIVRAD P01 Project - Development, Structure, and Function of Broadly Neutralizing anti-HIV Antibodies California Institute of Technology Division of Biology and Biological Engineering MC 114-96 \| 1200 E. California Blvd., Pasadena, CA 91125 (626) 395-8351 phone \| 626) 792-3683 fax murphym [at] caltech dot edu