2011

139. Diskin, R, Scheid, JF, Marcovecchio, PM, West, AP, Jr, Klein, F, Gao, H, Gnanapragasam, PNP, Abadir, A, Seaman, MS, Nussenzweig, MC, Bjorkman PJ (2011) Increasing the potency and breadth of an HIV antibody by using structure-based rational design. Science 334: 1289-1293. PMCID: PMC3232316 [Available on 2012/6/2] doi:10.1126/science.1213782
Abstract: http://www.sciencemag.org/cgi/content/abstract/science.1213782?ijkey=OdaHdAIwZneXc&keytype=ref&siteid=sci
Reprint: http://www.sciencemag.org/cgi/rapidpdf/science.1213782?ijkey=OdaHdAIwZneXc&keytype=ref&siteid=sci

138. West, AP, Jr., Galimidi, RP, Gnanapragasam, PNP, Bjorkman, PJ (2011) Single chain Fv-based anti-HIV proteins: Potential and Limitations. J. Virol. 86:195-202. doi:10.1128/JVI.05848-11

137. Bai, Y., Ye, L., Tesar, D.B., Song, H., Zhao. D., Bjorkman. P.J., Roopenian. D.C., Zhu, X. (2011) Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport. Proc. Natl. Acad. Sci. USA 108:18406-18411. PMCID: PMC3215070 [Available on 2012/5/8] doi:10.1073/pnas.1115348108

136. Keeffe, J.R., Gnanapragasam, P.N.P., Gillespie, S.K., Yong, J., Bjorkman, P.J., Mayo, S.L. (2011) Designed oligomers of cyanovirin show enhanced HIV neutralization. Proc. Natl. Acad. Sci. USA 108: 14079-14084. PMCID: PMC3161612 [Available on 2012/2/23] doi:10.1073/pnas.1108777108

135. He, Y., Bjorkman, P.J. (2011) Structure of FcRY, an avian immunoglobulin receptor related to mammalian mannose receptors, and its complex with IgY. Proc. Natl. Acad. Sci. USA 108:12431–12436. PMCID: PMC3145690 doi:10.1073/pnas.1106925108

134. Scheid, J.F., Mouquet, H. Ueberheide, B., Diskin, R., Klein, F., Olivera, T.Y., Pietzsch, J., Fenyo, D., Abadir, A., Velinzon, K., Hurley, A., Myung, S., Boulad, F., Poignard, P., Burton, D., Pereyra, F., Ho, D.D., Walker, B.D., Seaman, M.S., Bjorkman, P.J., Chait, B.T, Nussenzweig, M.C. (2011) Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science 333: 1633-1637. doi:10.1126/science.1207227

133. Luo X.M., Lei M.Y.Y., Feidi R.A., West A.P. Jr., Balazs A.B., Bjorkman, P.J., Yang, L. Baltimore D. (2010) Dimeric 2G12 as a Potent Protection against HIV-1. PLoS Pathog 6(12): e1001225. PMCID: PMC3002980 doi:10.1371/journal.ppat.1001225

132. Yang, F., West, A.P., Jr., Bjorkman, P.J. (2011) Crystal structure of a hemojuvelin-binding fragment of neogenin at 1.8 Å. J. Struct. Biol. 174: 239-244. PMCID: PMC3074981 doi:10.1016/j.jsb.2010.10.005

2010

131. Klein, J.S.*, Webster, A.*, Gnanapragasam, P.N.P., Galimidi, R.P., and Bjorkman, P.J. (2010) A dimeric form of the HIV-1 antibody 2G12 elicits potent antibody-dependent cellular cytotoxicity. AIDS 24: 1633-1640. PMCID: PMC2898891 doi:10.1097/QAD.0b013e32833ad8c8. Erratum in: AIDS. 2010 Oct 23;24(16):2601.
(*these authors contributed equally to the work)

130. Jerdeva, G.V., Tesar, D.B., Huey-Tubman, K.E., Ladinsky, M.S., Fraser, S.E, and Bjorkman, P.J. (2010) Comparison of FcRn- and pIgR-mediated transport in MDCK cells by fluorescence confocal microscopy. Traffic 11: 1205-1220. PMCID: PMC2975666 doi:10.1111/j.1600-0854.2010.01083.x

129. Klein, J.S., Bjorkman, P.J. (2010) Few and far between: how HIV may be evading antibody avidity. PLoS Pathogens 6(5): e1000908. PMCID: PMC2877745 doi:10.1371/journal.ppat.1000908

128. Diskin, R, Marcovecchio, PM, Bjorkman, P.J. (2010) Structure of a clade C HIV gp120 plus CD4 and a CD4-induced antibody reveals anti-CD4 polyreactivity. Nature Struct. Mol. Biol. 17: 608-613. PMCID: PMC2949298 doi:10.1038/nsmb.1796

127. Tesar, D.B. & Bjorkman, P.J. (2010) An intracellular traffic jam: Fc receptor-mediated transport of Immunoglobulin G. Curr. Opin. Struct. Biol. 20: 1-8. PMCID: PMC2865255 doi:10.1016/j.sbi.2010.01.010

126. Li, L, Fang, CJ, Ryan, JC, Niemi, EC, Lebrón, JA, Bjorkman, PJ, Arase, H, Torti, FM Torti, SV, Nakamura, MC, Seaman, WE (2010) Binding and uptake of H-ferritin is mediated by human transferrin receptor-1. Proc Natl Acad Sci USA 107: 3505-3510. PMCID: PMC2840523 doi:10.1073/pnas.0913192107

125. West, A.P., Jr., Galimidi, R.P., Foglesong, C.P., Gnanapragasam, P.N.P., Klein, J.S., Bjorkman, P.J. (2010) Evaluation of alternative CD4-CD4i antibody architectures yields potent, broadly cross-reactive anti-HIV reagents. J. Virol. 84: 261-269. PMCID: PMC2798438 doi:10.1128/JVI.01528-09

2009

124. Yang, Z., West, A.P., Jr., Bjorkman, P.J. (2009) Crystal structure of TNFalpha complexed with a poxvirus MHC-related TNF binding protein. Nature Struct. Mol. Biol. 16: 1189-1191. PMCID: PMC2819277 doi:10.1038/nsmb.1683

123. *He, Y., Jensen, G.J., Bjorkman, P.J. (2009) Nanogold as a specific marker for electron cryotomography. Microscopy and Microanalysis 15: 183-188. PMCID: PMC2785728
doi:10.1017/S1431927609090424

*Selected as the best Biological Sciences paper in Microscopy and Microanalysis in 2009.

122. Klein, J.S., Gnanapragsam, P.N.P., Galimidi, R.P., West, A.P., Jr., Bjorkman, P.J. (2009) Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10. Proc. Natl. Acad. Sci. USA 106: 7385-7390. PMCID: PMC2678646 doi:10.1073/pnas.0811427106

121. He, Y., Jensen, G.J., Bjorkman, P.J. (2009) Cryoelectron tomography of homophilic adhesion mediated by the neural cell adhesion molecule L1. Structure 17: 460-471. PMCID: PMC2744468 doi:10.1016/j.str.2009.01.009

120. Rice, A.E., Mendez, M.J., Hokanson, C.A., Rees, D.C., Bjorkman, P.J. (2009) Investigation of the biophysical and cell biological properties of ferroportin, a multi-pass integral membrane protein iron exporter. J. Mol. Biol. 386: 717-732. PMCID: PMC2677177 doi:10.1016/j.jmb.2008.12.063

119. West, A.P., Jr., Galimidi, R.P., Foglesong, C.P., Gnanapragasam, P.N.P., Huey-Tubman, K.E., Klein, J.S., Suzuki, M., Tiangco, N.E., Vielmetter, J., Bjorkman, P.J. (2009) Design and expression of a dimeric form of the anti-HIV antibody 2G12 with increased neutralization potency. J. Virology 83: 98-104. PMCID: PMC2612297 doi:10.1128/JVI.01564-08

2008

118. He, W., Ladinsky, M.S., Huey-Tubman K.E., Jensen, G.J., McIntosh, J.R., Bjorkman, P.J. (2008) FcRn-mediated antibody transport across epithelial cells revealed by electron tomography. Nature 455: 542-546. PMCID: PMC2773227 doi:10.1038/nature07255

117. Arnon, T.I., Kaiser, J.T., West, A.P. Jr., Olson, R., Diskin, R., Viertlboeck, B.C., Gobel, T.W., Bjorkman, P.J. (2008) The crystal structure of CHIR-AB1, a primordial avian classical Fc receptor. J. Mol. Biol. 381: 1012-1024. PMCID: PMC2603183 doi:10.1016/j.jmb.2008.06.082

116. Zhang, A.-S., Yang, F., Meyer, K., Hernandez, C., Chapman-Arvedon, T., Bjorkman, P.J, Enns, C.A. (2008) Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane. J. Biol. Chem. 283: 17494-17502. PMCID: PMC2427329 doi:10.1074/jbc.M710527200

115. Morphew, M., He, W., Bjorkman, P. J., and McIntosh, J. R. (2008). Silver enhancement of nanogold particles during freeze substitution fixation for electron microscopy. J Microscopy 230: 263-267. PMCID: PMC2722379 doi:10.1111/j.1365-2818.2008.01983.x

114. Yang, Z. and Bjorkman, P.J. (2008) Structure of UL18, a Peptide-Binding Viral MHC Mimic, Bound to a Host Inhibitory Receptor. Proc. Natl. Acad. Sci. USA 105: 10095-10100. PMCID: PMC2465803 doi:10.1073/pnas.0804551105

113. Schmidt, P.J., Toran, P.T., Giannetti, A.M. Bjorkman, P.J., Andrews, N.C. (2008) The transferrin receptor modulates HFE-dependent regulation of hepcidin expression. Cell Metabolism 7: 205-214. PMCID: PMC2292811 doi:10.1016/j.cmet.2007.11.016

112. Yang, F., West, A.P., Jr., Allendorph, G., Choe, S., Bjorkman, P.J. (2008) Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains. Biochemistry 47: 4237-4245. PMCID: PMC2819367 doi:10.1021/bi800036h

111. Tesar, D.B., Cheung, E.J., and Bjorkman, P.J. (2008) The chicken yolk sac IgY receptor, a mammalian mannose receptor family member, transcytoses IgY across polarized epithelial cells. Mol. Biol. of the Cell 19: 1587-1593. PMCID: PMC2291411 doi:10.1091/mbc.E07-09-0972

110. Sprague, E.R., Reinhard, H., Cheung, E.J., Farley, A.H., Trujillo, R.D., Hengel, H., Bjorkman, P.J. (2008) The human cytomegalovirus Fc receptor gp68 binds the Fc CH2-CH3 interface of IgG. J. Virology 82: 3490-3499. PMCID: PMC2268481 doi:10.1128/JVI.01476-07

2007

109. He, W., Kivork, C., Machinani, S. Morphew, M.K., Gail, A.M., Tesar, D.B., Tiangco, N.E., McIntosh, J.M., Bjorkman, P.J. (2007). A freeze substitution fixation-based gold enlarging technique for EM studies of endocytosed nanogold-labeled molecules. J. Struct. Biol. 160: 103-113. PMCID: PMC2076746 doi:10.1016/j.jsb.2007.07.004

108. Ja, W.W., West, A.P. Jr., Delker, S.L., Bjorkman, P.J., Benzer, S., Roberts, R.W. (2007) Extension of Drosophila lifespan with a G protein-coupled receptor inhibitor. Nature Chemical Biology 3: 415-419. PMCID: PMC2803097 doi:10.1038/nchembio.2007.2

107. Li, P., Huey Tubman, K.E., Gao, T., Li, X., West, A.P. Jr., Bennett, M.J., Bjorkman, P.J. (2007) The structure of a poly-Gln/anti-poly-Gln complex reveals binding according to a linear lattice model. Nature Structural & Molecular Biology 14: 381-387. doi:10.1038/nsmb1234

2006

106. Bjorkman, PJ (2006) Finding the groove. Nature Immunology 7: 787-789.doi:10.1038/ni0806-787

105. Tesar, D.B., Tiangco, N.E., Bjorkman, P.J. (2006) Ligand valency affects FcRn-mediated transcytosis, recycling, and intracellular trafficking. Traffic 7: 1-16. doi:10.1111/j.1600-0854.2006.00457.x

104. Olson, R., Dulac, C., Bjorkman, P.J. (2006) MHC homologs in the nervous system - They haven't lost their groove. Curr. Opin. Neurobiology 16: 351-357. doi:10.1016/j.conb.2006.05.007

103. Hamburger, A.E., Bjorkman, P.J., Herr, A.B. (2006) Structural insights into antibody-mediated mucosal immunity. Current Topics in Microbiology and Immmunology 308:173-204.dio:10.1007/3-540-30657-9_8

102. Sprague, E.R., Wang, C., Baker, D., Bjorkman, P.J. (2006) Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging. Public Library of Science (PLoS): Biology 4: 525-536. doi:10.1371/journal.pbio.0040148

101. Kacskovics, I., Kis, Z., Mayer, B., West, A.P., Tiangco, N.E., Tilahun, M., Cervenak, L., Bjorkman, P.J., Goldsby, R.A., Szenci, O., and Hammarström, L. (2006) FcRn mediates elongated serum half-life of human IgG in the cattle. International Immunology 18: 525-536. doi:10.1093/intimm/dxh393

100. McDermott, L.C., Freel, J.A., West, A.P., Bjorkman, P.J., and Kennedy, M.W. (2006) Zn-Alpha2-glycoprotein, an MHC Class I-Related Glycoprotein Regulator of Adipose Tissues: Modification or Abrogation of Ligand Binding by Site-Directed Mutagenesis. Biochemistry. Published on Web, January 16, 2006. doi:10.1021/bi051881v

2005

99. Giannetti AM, Halbrooks PJ, Mason AB, Vogt TM, Enns CA, Bjorkman PJ. (2005) The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin. Structure. 13:1613-23. doi:10.1016/j.str.2005.07.016

98. Zhang AS, West AP Jr, Wyman AE, Bjorkman PJ, Enns CA. (2005) Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells. J Biol Chem. 280:33885-94. doi:10.1074/jbc.M506207200

97. Halbrooks P.J., Giannetti A.M., Klein J.S., Bjorkman P.J., Larouche J.R., Smith V.C., MacGillivray R.T., Everse S.J., Mason A.B. (2005) Composition of pH-sensitive triad in C-lobe of human serum transferrin. Comparison to sequences of ovotransferrin and lactoferrin provides insight into functional differences in iron release. Biochemistry 44: 15451-15460. doi:10.1021/bi0518693

96. Olson, R., Huey-Tubman, K.E., Dulac, C., and Bjorkman, P.J. (2005) Structure of a Pheromone Receptor-Associated MHC Molecule with an Open and Empty Groove. Public Library of Science: Biology 3:1436-1448. doi:10.1371/journal.pbio.0030257

95. Hamburger, A.E., West Jr., A.P., Hamburger, Z.A., Hamburger,P., Bjorkman, P.J. (2005) Crystal structure of a secreted insect ferritin reveals a symmetrical arrangement of heavy and light chains. J. Mol. Biol. 349:558-569. doi.org/doi:10.1016/j.jmb.2005.03.074

94. Davis, M.I., Bennett, M.J., Thomas, L.M., and Bjorkman, P.J. (2005) Crystal structure of prostate-specific memb rane antigen, a tumor marker and peptidase. Proc. Natl. Acad. Sci. USA 102:5981-5986. doi 10.1073/pnas.0502101102

93. Luo, R., Mann, B., Lewis, W.S., Rowe, A., Heath, R. Stewart, M.L., Hamburger, A.E., Sivakolundu, S., Lacy, E.R., Bjorkman, P.J., Tuomanen, E., Kriwacki, R.W. (2005) Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae. EMBO J., 24:34-43. doi:10.1038/sj.emboj.7600490

2004

92. Hamburger, A.E., West, A.P., Jr., Bjorkman, P.J. (2004) Crystal structure of a polymeric immunoglobulin-binding fragment of the human polymeric immunoglobulin receptor. Structure 12:1925-1935. doi:10.1016/j.str.2004.09.006

91. Delker, S.L., West, A.P., Jr., McDermott, L., Kennedy, M.W., Bjorkman, P.J. (2004) Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein. J. Struct. Biol. 148:205-213. doi:10.1016/j.jsb.2004.04.009

90. Giannetti. A.M., and Bjorkman, P.J. (2004) HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface. J. Biol. Chem 279:25866-25875. doi:10.1074/jbc.M401467200

89. West, A.P., Jr., Herr, A.B., and Bjorkman, P.J. (2004) The chicken yolk sac IgY receptor, a functional equivalent of the mammalian MHC-related Fc receptor, is a phospholipase A2 receptor homolog. Immunity 20:601-610. doi:10.1016/S1074-7613(04)00113-X

88. Sprague, E.R., Martin, W.L., Bjorkman, P.J. (2004) pH-dependence and stoichiometry of binding to the Fc region of IgG by the herpes simplex virus Fc receptor gE-gI. J. Biol. Chem 279:14184-14193. doi:10.1074/jbc.M313281200

2003

87. Giannetti. A.M., Snow, P.M., Zak, O., and Bjorkman, P.J. (2003) Mechanism for Multiple Ligand Recognition by the Human Transferrin Receptor. Public Library of Science: Biology 1:341-350. doi:10.1371/journal.pbio.0000051

86. Willcox, B.E., Thomas, L.E., Bjorkman, P.J. (2003) Crystal structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor. Nat. Immunol. 4:913-919. doi:10.1038/ni961

85. Herr, A.B., Ballister, E.R., Bjorkman, P.J. (2003) Insights into IgA-mediated immune responses from the crystal structures of human FcaRI and its complex with IgA1-Fc. Nature 423:614-620. doi:10.1038/nature01685

84. Herr, A.B., White, C.L., Milburn, C., Wu, C., & Bjorkman, P.J. (2003) Bivalent binding of IgA1 to FcaRI suggests a mechanism for cytokine activation of IgA phagocytosis. J. Mol. Biol. 327:645-657. doi:10.1016/S0022-2836(03)00149-9

83. Vogt, T.M., Blackwell, A.D., Giannetti, A.M., West, A.P., Jr., Bjorkman, P.J., Enns, CA (2003) Heterotypic interactions between TfR2 and TfR. Blood 101: 2008-2014. doi:10.1182/blood-2002-09-2742

2002

82. Willcox. B.E., Thomas L.M., Chapman, T.L., Heikema A.P., West Jr., A.P., Bjorkman P.J. (2002) Crystal Structure of LIR-2 (ILT4) at 1.8Å: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18. BioMedCentral Structural Biology 2: 1-9. doi:10.1186/1472-6807-2-6

81. Bennett, M.J., Huey-Tubman, K.E., Herr, A.B., West, A.P., Jr., Ross, S.A., Bjorkman, P.J. (2002) A linear lattice model for polyglutamine in CAG expansion diseases. Proc Natl Acad Sci USA 99:11634-11639. doi:10.1073/pnas.182393899

2001

80. West, AP, Jr., Giannetti, AM, Herr, AB, Bennett, MJ, Nangiana, JS, Pierce, JR, Snow, PM, and Bjorkman, PJ (2001) Mutational Analysis of the Transferrin Receptor Reveals Overlapping HFE and Transferrin Binding Sites. J. Mol. Biol. 313 385-397. doi:10.1006/jmbi.2001.5048

79. Kennedy, M.W., Heikema, A.P., Cooper, A., Bjorkman, P.J., and Sanchez, L.M. (2001) Hydrophobic ligand binding by ZAG, a soluble fat-depleting factor related to class I MHC proteins. J. Biol. Chem. 276: 35008-35013. doi:10.1074/jbc.C100301200

78. O'Callaghan, C.A., Cerwenka, A., Willcox, B.E., Lanier, L.L., and Bjorkman, P.J. (2001) Molecular Competition for NKG2D: H60 and RAE1 Compete Unequally for NKG2D with Dominance of H60. Immunity 15: 201-211. doi:10.1016/S1074-7613(01)00187-X

77. Martin, W.L., West, Jr., A.P., Gan, L., Bjorkman, P.J. (2001) Crystal structure at 2.8 Å of an FcRn/heterodimeric Fc complex: mechanism of pH dependent binding. Molecular Cell 7: 867-877. doi:10.1016/S1097-2765(01)00230-1

76. West, A.P., Llamas, L.L., Snow, P.M. Benzer, S., and Bjorkman, P.J. (2001). Crystal structure of the ectodomain of methuselah: A Drosophila G protein-coupled receptor associated with extended life-span. . Proc. Natl. Acad. Sci., USA 98: 3744-3749. doi:10.1073/pnas.051625298

75. Liu, Y., Misulovin, Z., and Bjorkman, P.J. (2001) The molecular mechanism of sulfated carbohydrate recognition by the cysteine-rich domain of mannose receptor. J. Mol. Biol. 305: 481-490. doi:10.1006/jmbi.2000.4326

2000

74. West, A.P., Bennett, M.J., Sellers, V.M., Andrews, N.C., Enns, C.A., Bjorkman P.J. (2000). Comparisons of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J. Biol. Chem. 275: 38135-38138. doi:10.1074/jbc.C000664200

73. Chapman, T.L., Heikema, A.P., West, A.P., and Bjorkman, P.J. (2000). Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2). Immunity 13:727-736. doi:10.1016/S1074-7613(00)00071-6

72. West, A.P. Bjorkman, P.J. (2000) Crystal structure and immunoglobulin G binding properties of the human MHC-related Fc receptor. Biochemistry 39: 9698-9708. doi:10.1021/bi000749m

71. Liu, Y., Chirino, A.J., Leteux, C., Feizi, T., Misulovin, Z., Nussenzweig, M.C., Bjorkman, P.J (2000) Crystal Structure of the Cysteine Rich Domain of Mannose Receptor Complexed with a Sulfated Carbohydrate Ligand. J. Exp. Med. 191: 1105-1116. Published online Mar 27 2000. doi:10.1084/jem.191.7.1105

70. Bennett, M.J., Lebrón, J.A. & Bjorkman, P.J. (2000) Crystal structure of the hereditary hemochromatosis protein HFE complexed with transferrin receptor. Nature 403: 46-53. doi:10.1038/47417

1999

69. Lebrón, J.A., West, A.P., Bjorkman, P.J. (1999) The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor. J. Mol. Biol. 294: 239-245.

68. Chapman, T.L., Heikema, A.P. & Bjorkman, P.J. (1999) The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral MHC homolog UL18. Immunity 11: 603-613.

67. Martin, W.L. & Bjorkman, P.J. (1999) Characterization of the 2:1 complex between the class I MHC-related Fc receptor and its Fc ligand in solution. Biochemistry 38: 12639-12647.

66. Hamburger, Z.A., Brown, M.S., Isberg, R.R. & Bjorkman, P.J. (1999) Crystal structure of invasin: a bacterial integrin-binding protein. Science 286: 291-295.

65. Hanke, T., Takizawa, H. McMahon, C.W., Busch, D.H., Pamer, E.G., Miller, J.D., Altman, J.D., Liu, Y., Cado, D., Lemonnier, F.A., Bjorkman, P.J., & Raulet, D.H. (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11, 67-77.

64. Sánchez, L.M., Penny, D.M. & Bjorkman, P.J. (1999) Stoichiometry of the interaction between the MHC-related Fc receptor and its Fc ligand. Biochemistry 38: 9471-9476.

63. Lebrón, J.A. & Bjorkman, P.J. (1999). The Transferrin Receptor Binding Site on HFE, the Class I MHC-Related Protein Mutated in Hereditary Hemochromatosis. J. Mol. Biol. 289: 1109-1118.

62. Sánchez, L.M.*, Chirino, A.J.* & Bjorkman, P.J. (1999) Crystal structure of human Zn-alpha2-glycoprotein: a fat-depleting factor related to MHC molecules. Science 283: 1914-1919. (* these authors contributed equally to the work)

61. Chapman, T.L., You, I., Joseph, I.M., Bjorkman, P.J., Morrison, S.L. & Raghavan, M. (1999). Characterization of the interaction between the herpes simplex virus type I Fc receptor and Immunoglobulin G. J. Biol. Chem. 274: 6911-6919.

60. Lebrón, J.A., Shen, H., Bjorkman, P.J., & Ou, S. (1999) Tolerization of adult mice to immunodominant proteins before monoclonal antibody production. J. Immunol. Meth. 222/1-2: 59-63.

1998

59. Su, X.-D., Gastinel, L.N., Vaughn, D.E., Faye, I., Poon, P., & Bjorkman, P.J. (1998) Crystal structure of hemolin: A horseshoe shape with implications for homophilic adhesion. Science 281: 991-995.

58. Lebrón, J.A.*, Bennett, M.J.*, Vaughn, D.E., Chirino, A.J., Snow, P.M., Mintier, G.A., Feder, J.N., & Bjorkman, P.J. (1998) Crystal Structure of the Hemochromatosis Protein HFE and Characterization of its Interaction with Transferrin Receptor. Cell 93:111-123. (* these authors contributed equally to the work)

57. Feder, J.N., Penny, D.M., Irrinke, A., Lee, V.K., Lebrón, J.A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P.J. & Schatzman, R.C. (1998) The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc. Natl. Acad. Sci. USA 95: 1472-1477.

56. Weng, Z., Gulukota, K., Vaughn, D.E., Bjorkman, P.J., and DeLisi, C. (1998) Computational determination of the structure of rat Fc bound to the neonatal Fc receptor. J. Mol. Biol. 282: 217-225.

55. Leong, C.C., Chapman, T.L., Bjorkman, P.J., Formankova, D., Mocarski, E.S., Phillips, J.H., & Lanier, L.L. (1998) Modulation of natural killer cell cytotoxicity in human cytomegalovirus infection: The role of endogenous class I MHC and a viral class I homolog. J. Exp. Med. 187: 1681-1687.

54. Wilson, I.A. & Bjorkman, P.J. (1998) Unusual MHC-like molecules: CD1, Fc receptor, the hemochromatosis gene product, and viral homologs. Curr. Opin in Immunol. 10: 67-73.

53. Vaughn, D.E. & Bjorkman, P.J. (1998) Structural basis of pH dependent antibody binding by the neonatal Fc receptor. Structure 6: 63-73.

52. Chapman, T.L. and Bjorkman, P.J. (1998) Characterization of a murine cytomegalovirus class I MHC homolog: Comparison to MHC molecules and to the human cytomegalovirus MHC homolog. J. Virol. 72: 460-466.

1997

51. Vaughn, D.E., Milburn, C.M., Penny, D.M., Martin, W.L.M., Johnson, J.L. and Bjorkman, P.J. (1997) Identification of critical IgG binding epitopes on the neonatal Fc receptor. J. Mol. Biol. 274: 597-607.

50. West, A.P., Bjorkman, P.J., Dougherty, D.A. and Lester, H.A. (1997) Expression and circular dichroism studies of the extracellular domain of the a subunit of the nicotinic acetylcholine receptor. J. Biol. Chem. 272: 25468-25473.

49. Vaughn, D.E. and Bjorkman, P.J. (1997) High affinity binding of the neonatal Fc receptor to its IgG ligand requires receptor immobilization. Biochemistry 36: 9374-9380.

48. Morgan, C.S., Holton, J.M., Olafson, B.D., Bjorkman, P.J., Mayo, S.L. (1997) Circular dichroism determination of class I MHC-peptide equilibrium dissociation constants. Protein Science 6: 1771-1773.

47. Bjorkman, P.J. (1997) MHC restriction in three dimensions: A view of T cell receptor/ligand interactions. Cell 89: 167-170.

46. Sánchez, L.M., López-Otín, C., and Bjorkman, P.J. (1997) Biochemical characterization and crystallization of human Zn-alpha2-glycoprotein, a soluble class I MHC homolog. Proc. Natl. Acad. Sci. USA 94: 4626-4630.

1996

45. Gakamsky, D., P.J. Bjorkman, and I. Pecht (1996) Peptide Interaction with a class I major histocompatibility complex-encoded molecule: Allosteric control of the ternary complex stability. Biochemistry 35: 14841-14848.

44. Raghavan, M., J.A. Lébrón, J.L. Johnson, and P.J. Bjorkman (1996) Extended repertoire of permissible peptide ligands for HLA-B*2702. Protein Science 5: 2080-2088.

43. Raghavan, M. and P.J. Bjorkman (1996) Fc receptors and their interactions with immunoglobulins. Ann. Rev. Cell Dev. Biol. 12: 181-220.

42. Vaughn, D.E. and P.J. Bjorkman (1996) The (Greek) Key to structures of neural adhesion molecules. Neuron 16: 261-273.

1995

41. Raghavan, M., V.R. Bonagura, S.L. Morrison, and P.J. Bjorkman (1995) Analysis of the pH dependence of neonatal Fc receptor/Immunoglobulin G interaction using antibody and receptor variants. Biochemistry 34: 14649-14657.

40. Fahnestock, M.L., J.L. Johnson, R.M.R. Feldman, J.M. Neveu, W.S. Lane, and P.J. Bjorkman (1995) The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides. Immunity 3: 583-590.

39. Raghavan, M., Y. Wang, and P.J. Bjorkman (1995) Effects of Receptor Dimerization on the Interaction between the class I MHC-related Fc Receptor and Immunoglobulin G. Proc. Natl. Acad. Sci. USA 92: 11200-11204.

38. Raghavan, M.and P.J. Bjorkman (1995) BIAcore: A microchip-based system for analyzing the formation of macromolecular complexes. Structure 3:331-333.

1994

37. Bjorkman, P.J. and W.P. Burmeister (1994) Structure of two classes of MHC molecules elucidated: Crucial differences and similarities. Curr. Opin. in Struct. Biol. 4: 852-856.

36. Burmeister, W.P., A.H. Huber, and P.J. Bjorkman (1994) Crystal structure of the complex of rat neonatal Fc receptor with Fc. Nature 372: 379-383.

35. Burmeister, W.P., L.N. Gastinel, N.E. Simister, M.L. Blum, and P.J. Bjorkman (1994) Crystal structure at 2.2 Å resolution of the rat neonatal Fc receptor. Nature 372: 336-343.

34. Strong, R.K., D.M. Penny, R.M.R. Feldman, L.P. Weiner, J.J. Boniface, M.M. Davis, and P.J. Bjorkman (1994) Engineering and expression of a secreted murine T cell receptor with reduced N-linked glycosylation. J. Immunol 153: 4111-4121.

33. Strong, R.K., D. Vaughn, P.J. Bjorkman, and P.M. Snow (1994) Expression and crystallization of the extracellular domains of Drosophila fasciclin III. J. Mol. Biol. 241: 483-487.

32. Raghavan, M., L.N. Gastinel, M.Y. Chen, and P.J. Bjorkman (1994) Investigation of the interaction between the class I MHC-related Fc receptor and its immunoglobulin G ligand. Immunity 1: 303-315.

31. Fahnestock, M.L., J.L. Johnson, R.M.R. Feldman, T.J. Tsomides, J. Mayer, L. Narhi and P.J. Bjorkman (1994) The effects of peptide length and composition on binding to an empty class I MHC heterodimer. Biochemistry 33: 8149-8158.

30. Huber, A.H., Y.-M.E. Wang, A.J. Bieber and P.J. Bjorkman (1994) Crystal structure of tandem type III fibronectin domains from Drosophila neuroglian at 2.1 Å. Neuron 12: 717-731.

29. Fahnestock, M.L., M. McMillan, J.M. Dadgari and P.J. Bjorkman (1994) Phosphatidyl inositol linked forms of a murine class I MHC molecule expressed on CHO cells retain peptide binding capability and alloreactivity. International Immunology 6: 307-314.

1993

28. Raghavan, M., L.N. Gastinel and P.J. Bjorkman (1993) The class I major histocompatibility complex related Fc receptor shows pH-dependent stability differences correlating with immunoglobulin binding and release. Biochemistry 32: 8654-8660.

27. Bjorkman, P.J. and D.C. Wiley (1993) The human class I histocompatibility antigen, HLA-A2. Structure 1: xiv-xv.

26. Huber, A.H., L.N. Gastinel, R.F. Kelly and P.J. Bjorkman. (1993) Crystallization and stoichiometry of binding of a complex between a rat intestinal Fc receptor and Fc. J. Mol. Biol. 230: 1077-1083.

25. Wang, W.-C., K. Zinn and P.J. Bjorkman. (1993) Expression, structural and functional studies of fasciclin I, an insect cell adhesion molecule. J. Biol. Chem. 268: 1448-1455.

1992

24. Fahnestock, M.L., I. Tamir, L. Narhi and P.J. Bjorkman. (1992) Thermal stability comparison of purified empty and peptide filled forms of a class I MHC molecule. Science 258: 1658-1662.

23. Gastinel, L.N., N.E. Simister and P.J. Bjorkman. (1992) Expression and crystallization of a soluble and functional form of an Fc receptor related to class I MHC molecules. Proc. Natl. Acad. Sci USA 89: 638-642.

1991

22. Devaux, B., P.J. Bjorkman, C. Stevenson, W. Greif, J.F. Elliott, C. Sagerstrom, C. Clayberger, A.M. Krensky and M.M. Davis. (1991) Generation of monoclonal antibodies against soluble human T cell receptor polypeptides. Eur J. Immunology 21: 2111-2119.

21. Saper, M.A., P.J. Bjorkman and D.C. Wiley. (1991) Refined structure of the human histocompatibility antigen HLA-A2 at 2.6Å resolution. J. Mol. Biol. 219: 277-319.

1990

20. Chamow, S.M., D.H. Peers, R.A. Byrn, M.G. Mulkerrin, R.J. Harris, W.-C. Wang, P.J. Bjorkman, D.J. Capon and A. Ashkenazi. (1990) Enzymatic cleavage of an immunoadhesin generates crystallizable, Fd-like fragments of an immunoglobulin gene superfamily member, CD4. Biochemistry 29: 9885-9891.

19. Davis, M.M., B. F. de St. Groth, L.J. Berg, A. Lin, B. Devaux, C. Sagerstrom, J.F. Elliott and P.J. Bjorkman. (1990) Selection of an ab T-cell antigen receptor in vivo and expression in vitro in a soluble form. In Current Topics in Membranes and Transport, 36: 155-159, 1990.

18. Bjorkman, P.J. and M.M. Davis. (1990) Structure of a human histocompatibility molecule: Implications for its interactions with peptides and T cell receptors. In Use of X-ray Crystallography in the Design of Antiviral Agents, (eds. W. Graeme Laver and Gillian M. Air) pp. 19-34.

17. Bjorkman, P.J.and P. Parham. (1990) Structure, function and diversity of class I major histocompatibility complex molecules. Ann. Rev. Biochem. 90: 253-88.

1989

16. Garrett, T.P.J., M.A. Saper, B. Samraoui, P.J. Bjorkman and D. C.Wiley. (1989) Structure/function studies of major histocompatibility antigens. Transplantation Proceedings 21:l, 588-590.

15. Davis, M.M., B.F. de St. Groth, A. Lin, B. Devaux, C. Sagerström, J.F. Elliott, and P.J. Bjorkman. (1989) Selection of an ab T cell antigen receptor in vivo and engineering a solulizable form. In the Proceedings of the 7th International Congress of Immunology, Progress in Immunology VII, pp. 16-21.

14. Davis, M.M., L.J. Berg, A.Y. Lin, B. F. de St. Groth, B. Devaux, C.G. Sagerström, P.J. Bjorkman, J.F. Elliott. (1989) TCR recognition and Selection in vivo. In Symposium on Immunological Recognition (Proceedings). Cold Spring Harbor Lab. Press, pp. 119-128.

13. Bjorkman, P.J. and M.M Davis. (1989) A model for the interaction of a T cell receptor with a peptide-MHC complex. In Symposium on Immunological Recognition (Proceedings). Cold Spring Harbor Lab. Press, pp. 365-373.

12. Garrett, T.P.J., M.A. Saper, P.J. Bjorkman, J.L. Strominger and D.C.Wiley. (1989) Specificity pockets for the side chains of peptide antigens in HLA-Aw68. Nature 342: 692-96.

11. Madden, D., M. A.Saper, T.P.J. Garrett, P.J. Bjorkman, J.L. Strominger, and D.C. Wiley. (1989) A comparison of orthorhombic and monoclinic crystal structures of HLA-A2. In Symposium on Immunological Recognition (Proceedings). Cold Spring Harbor Lab. Press. p. 353-359

1988

10. Bjorkman, P.J., W.S. Bennett and D.C. Wiley. (1988) Data collection from very thin HLA crystals using synchrotron radiation. In Proceedings of Brookhaven Symposium in Biology No. 35 on Synchrotron Radiation in Structural Biology, Plenum Publishing Corporation, New York, NY, p. 123-131.

9. Saper, M.A., P.J. Bjorkman and D.C. Wiley. (1988) Iterative molecular averaging and phase refinement of two HLA-A2 crystal forms. In Proceedings of the Daresbury Study Weekend , 5-6 February, (eds. S. Phillips, E. Dodson, and S. Bailey), Science and Engineering Research Council, pp. 39-48.

8. Davis, M.M. and P.J. Bjorkman. (1988) T cell antigen receptor genes and T cell recognition. Nature 334: 395-402.

7. Brown, J.H., T. Jardetsky, M.A. Saper, B. Samraoui, P.J. Bjorkman and D.C. Wiley. (1988) A hypothetical model of the foreign antigen binding site of class II histocompatibility antigens. Nature 332:845-850.

1987

6. Bjorkman, P.J., M.A. Saper, B. Samraoui, W.S. Bennett, J.L. Strominger and D.C. Wiley. (1987) The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329:512-518.

5. Bjorkman, P.J., M.A. Saper, B. Samraoui, W.S. Bennett, J.L. Strominger and D.C. Wiley. (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329:506-512.

1985

4. Bjorkman, P.J., J.L. Strominger and D.C. Wiley. (1985) Crystallization and x-ray diffraction studies on the histocompatibility antigens HLA-A2 and HLA-A28 from human cell membranes. J. Mol. Biol. 186:205-210.

1984

3. Bjorkman, P.J. Crystallographic studies of HLA. PhD Thesis, Harvard University, June, l984.

1979

2. Lee, T.D., G.B. Birrell, P.J. Bjorkman and J.F.W. Keana. (1979) Azethoxyl Nitroxide Spin Labels: ESR studies involving thiourea crystals, model membrane systems and chromatophores, and chemical reduction with ascorbate and dithiothreitol. Biochim. Biophys. Acta 550:369-383.

1976

1. Bjorkman, P.J. and L.B. Church. (1976) Comparison of zinc/copper ratios in tissues of a control group versus victims of atheroschlerotic heart disease. Proc. Oregon Acad. Sciences 78.