Publications
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Del Real MM, Rothenberg EV. Architecture of a lymphomyeloid developmental switch controlled by PU.1, Notch and Gata3. Development. 140(6), 1207-19
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Yui MA, Feng N, Zhang JA, Liaw CY, Rothenberg EV, Longmate JA. Loss of T cell progenitor checkpoint control underlies leukemia initiation in rag1-deficient nonobese diabetic mice. J Immunol. 190(7), 3276-88
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Manesso E, Chickarmane V, Kueh HY, Rothenberg EV, Peterson C. Computational modelling of T-cell formation kinetics: output regulated by initial proliferation-linked deferral of developmental competence. J R Soc Interface. 10(78), 20120774
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Zhang JA, Mortazavi A, Williams BA, Wold BJ, Rothenberg EV. Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity. Cell. 149(2), 467-82
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Rothenberg EV. Transcriptional drivers of the T-cell lineage program. Curr Opin Immunol. 24(2), 132-8
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Zarnegar MA, Rothenberg EV. Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer. Oncogene. 31(43), 4647-54
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Kueh HY, Rothenberg EV. 2011. Regulatory gene network circuits underlying T-cell development from multipotent progenitors. Wiley Interdiscip. Rev. Syst. Biol. Med. 4(1), 79-102
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Rothenberg EV, Zhang JA. 2011. T-Cell Identity and Epigenetic Memory. Curr Top Microbiol Immunol. 356, 117-43
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Rothenberg EV. 2011.T cell lineage commitment: identity and renunciation. J Immunol 186(12), 6649-55.
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Feng N, Vegh P, Rothenberg EV, Yui MA. 2011. Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice. J Immunol 186(2), 826-37.
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Rothenberg EV. 2010. Lineage determination in the immune system. Immunol Rev. 238(1), 5-11
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Rothenberg EV, Zhang J, Li L. 2010. Multilayered specification of the T-cell lineage fate. Immunol Rev. 238(1), 150-68.
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Zarnegar MA, Chen J, Rothenberg EV. 2010. Cell-type-specific activation and repression of PU.1 by a complex of discrete, functionally specialized cis-regulatory elements. Mol. Cell Biol. 30(20), 4922-39.
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Li L, Leid M, Rothenberg EV. 2010. An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b. Science. 329(5987), 89-93
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Yui MA, Feng N, Rothenberg EV. 2010. Fine-scale staging of T cell lineage commitment in adult mouse thymus. J Immunol. 185(1), 284-93
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David-Fung, E.-S., Butler R, Buzi G, Yui, M. A., Diamond, R. A., Anderson M, Rowen L, and Rothenberg, E. V. 2009. Transcription factor expression dynamics of early T-lymphocyte specification and commitment . Developmental Biology 325(2), 444-467 .
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Rothenberg EV, Scripture-Adams DD. 2008. Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination. Semin. Immunol. 20, 236-246 .
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Georgescu C, Longabaugh W, Scripture-Adams D, David-Fung E, Yui M, Zarnegar M, and Bolouri H, and Rothenberg EV. 2008. A gene regulatory network armature for T lymphocyte specification. PNAS 105(51), 20100-20105.
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Rothenberg, E. V., Moore, J. E., and Yui, M. A. 2008. Launching the T-lineage developmental programme. Nat. Rev. Immunol. 8, 9-21.
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Taghon, T., Yui, M. A., and Rothenberg, E. V. 2007. Mast cell lineage diversion of T lineage precursor cells by the essential T cell transcription factor GATA-3. Nat. Immunol. 8, 845-855.
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Rothenberg, E. V. 2007. Negotiation of the T-lineage fate decision by transcription factor interplay and microenvironmental signals. Immunity 26, 690-702.
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Tydell, C. C., David-Fung, E.-S., Moore, J. E., Rowen, L., Taghon, T., and Rothenberg, E. V. 2007. Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway. J. Immunol. 179, 421-438.
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Rothenberg, E. V. 2007. Regulatory factors for initial T-lymphocyte lineage specification. Curr. Opin. Hematol. 14, 322-329.
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Rothenberg, E. V. 2007. Cell lineage regulators in B and T cell development. Nat. Immunol. 8, 441-444.
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Taghon T, Yui MA, Pant R, Diamond RA, Rothenberg EV. 2006. Developmental and molecular characterization of emerging β- and γδ-selected pre-T cells in the adult mouse thymus Immunity. 24, 53-64.
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Franco, C. B., Scripture-Adams, D. D., Proekt, I., Taghon, T., Weiss, A. H., Yui, M. A., Adams, S. L., Diamond, R. A., and Rothenberg, E. V. 2006. Notch/Delta signaling constrains re-engineering of pro-T cells by PU.1. Proc. Natl. Acad. Sci. USA 103, 11993-11998.
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David-Fung, E.-S., Yui, M. A., Morales, M., Wang, H., Taghon, T., Diamond, R. A., and Rothenberg, E. V. 2006. Progression of regulatory gene expression states in fetal and adult pro-T cell development. Immunol. Rev. 209, 212-236.
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Taghon, T., David, E.-S., Zúñiga-Pflücker, J. C., and Rothenberg, E. V. 2005. Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling. Genes Dev. 19, 965-978.
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Dionne, C. J., Tse, K. Y., Weiss, A. H., Franco, C. B., Wiest, D. L., Anderson, M. K., and Rothenberg, E. V. 2005. Subversion of T lineage commitment by PU.1 in a clonal cell line system. Devel. Biol. 280, 448-466.
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Rothenberg, E. V. and Taghon, T. 2005. Molecular genetics of T-cell development. Annu. Rev. Immunol. 23, 601-649.
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Warren, L. A. and Rothenberg, E. V. 2003. Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors. Curr. Opin. Immunol. 15, 166-175.
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Hernández-Hoyos, G., Anderson, M. K., Wang, C., Rothenberg, E. V., and Alberola-Ila, J. 2003. GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation. Immunity 19, 83-94.
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Rothenberg, E. V. and Dionne, C. J. 2002. Lineage plasticity and commitment in T-cell development. Immunol. Rev. 187, 96-115.
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Rothenberg, E. V. 2002. T lineage specification and commitment: a gene regulation perspective. Semin. Immunol. 14, 431-440.
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Anderson, M. K., Hernandez-Hoyos, G., Dionne, C. J., Arias, A. M., Chen, D., and Rothenberg, E. V. 2002. Definition of regulatory network elements for T-cell development by perturbation analysis with PU.1 and GATA-3. Devel. Biol. 246, 103-121.
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Rothenberg, E. V. and Anderson, M. K. 2002. Elements of transcription factor network design for T-lineage specification. Devel. Biol. 246, 29-44.
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Anderson, M. K., Weiss, A. H., Hernandez-Hoyos, G., Dionne, C. J., and Rothenberg, E. V. 2002. Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage. Immunity 16, 285-296.