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1) All publications supported by HIVRAD funding must be in compliance with NIH's mandatory Public Access Policy (http://publicaccess.nih.gov/). The NIH will delay processing of an award if publications supported by a grant are not in compliance with this policy.
2) Each publication, press release, or other document about research supported by an NIH award must include an acknowledgment of NIH award support and a disclaimer such as “Research reported in this publication was supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number P01AI100148. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.” Prior to issuing a press release concerning the outcome of this research, please notify the NIH awarding IC in advance to allow for coordination.

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2021

13. Jette, CA, Barnes, CO, Kirk, SM, Melillo, B, Smith, III AB, Bjorkman, PJ (2021) Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation. Nat Commun Mar 29;12(1):1950 doi:10.1038/s41467-021-21816-x

12. Viant, C, Escolano, A, Chen, ST, Nussenzweig, MC. (2021) Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells. STAR Protoc. Mar 15;2(2):100389. PMCID: PMC7985702 doi:10.1016/j.xpro.2021.100389

11. Nishimura Y, Donau OK, Dias J, Ferrando-Martinez S, Jesteadt E, Sadjadpour R, Gautam R, Buckler-White A, Geleziunas R, Koup RA, Nussenzweig MC, Martin MA. (2021) Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia. J Exp Med 218 (1):e20201214. PMCID: PMC7953630 doi:10.1084/jem.20201214.

2020

10. Viant C, Weymar GHJ, Escolano A, Chen S, Hartweger H, Cipolla M, Gazumyan A, Nussenzweig MC. (2020) Antibody Affinity Shapes the Choice between Memory and Germinal Center B Cell Fates. Cell 183: 1298-1311.e11. PMCID: PMC7722471 doi:10.1016/j.cell.2020.09.063.

9. Wang, Z, Barnes, CO, Gautam, R, Cetrulo Lorenzi, JC, Mayer, CT, Oliveira, TY, Ramos, V, Cipolla, M, Gordon, KM, Gristick, HB, West, AP, Nishimura, Y, Raina, H, Seaman, MS, Gazumyan, A, Martin, M, Bjorkman, PJ, Nussenzweig, MC, Escolano, A (2020) A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch. eLife 9 :e61991. PMCID: PMC7577740 doi:10.7554/eLife.61991

8. Jette, CA, Barnes, CO, Kirk, SM, Melillo, B, Smith III, AB, Bjorkman PJ (2020) Cryo-EM Structures of HIV-1 trimer bound to CD4-mimetics M48U1 and BNM-III-170 adopt a CD4-bound open conformation. bioRxiv doi:10.1101/2020.08.21.261974

7. *Schommers, P, *Gruell, H, *Abernathy, ME, Tran, M-K, Dingens, AS, Gristick, HB, Barnes, CO, Schoofs, T, Schlotz, M. Vanshylla, K, Kreer, C, Weiland, D, Holtick U, Scheid, C, Valter, MM, van  Gils, MJ, Sanders RW, Vehreschild, JJ, Cornely, OA, Lehmann, C, Fatkenheuer, G, Seaman, MS, Bloom, JD, Bjorkman PJ, Klein, F. (2020) Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody. Cell 180: 471-489 *co-first authors. PMCID: PMC7042716 doi:10.1016/j.cell.2020.01.010

6. Wang, Z, Merkenschlager, J, Chen, ST, Oliveira, TY, Ramos, V, Gordon, KM, Ya,o KH, Jankovic, M, Nussenzweig, M, Escolano, A (2020) Isolation of single HIV-1 Envelope specific B cells and antibody cloning from immunized rhesus macaques. J Immunol Methods 478:112734 PMCID: PMC6961706 doi:10.1016/j.jim.2019.112734

5. Cohen, AA, Yang, Z, Gnanapragasam, P, Ou, S, Dam, K-M, Wang, H, Bjorkman, PJ (2020) Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers. bioRxiv. doi:10.1101/2020.01.18.911388

2019

4. Yang, Z, Wang, H, Liu, AZ, Gristick, HB, Bjorkman, PJ (2019) Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody reveals intermediate states induced by CD4 binding. Nature Struct Mol Biol 26: 1167-1175 PMCID: PMC6899201 doi:10.1038/s41594-019-0344-5

3. Einav, T, Yazdi, S, Coey, A, Bjorkman, PJ, Phillip,s R. (2019) Harnessing Avidity: Quantifying the Entropic and Energetic Effects of Linker Length and Rigidity for Multivalent Binding of Antibodies to HIV-1. Cell Syst. 9: 466-474 PMCID: PMC6892280 doi:10.1016/j.cels.2019.09.007

2. *Escolano, A, *Gristick, HB, Abernathy, ME, Merkenschlager, J, Gautam, R, Oliveira, TY, Pai, J, West, AP, Barnes, CO, Cohen, AA, Wang, H, Golijanin, J, Yost, D, Keeffe, JR, Wang, Z, Zhao, P, Yao, K-H, Bauer, J, Nogueira, L, Gao, H, Voll, AV, Montefior, DC, Seaman, MS, Gazumyan, A, Silva, M, McGuire, AT, Stamatatos, L, Irvine, DJ, Wells, L, Martin, MA, Bjorkman, PJ, Nussenzweig, MC (2019) Immunization expands HIV-1 glycan patch-specific B-cells in mice and macaques. Nature 570: 468-73. *co-first authors. PMCID: PMC6657810 doi:10.1038/s41586-019-1250-z

1. *Schoofs, T, *Barnes, CO, Suh-Toma, N, Golijanin, J, Schommers, P, Gruell, H, West, AP, Back, F, Lee, YE, Nogueria, L, Georgiev, IS, Bailer, RT, Czartoski, J, Mascola, JR, Seaman, MS, McElrath, MJ, Doria-Rose, NA, Klein, F, Nussenzweig, MC, Bjorkman, PJ (2019) Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope. Immunity 50: 1513-29. *co-first authors. PMCID: PMC6591006 doi:10.1016/j.immuni.2019.04.014

 

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> previous publications 2013-2018

2018

56. Wang, H*, Barnes, CO*, Yang, Z, Nussenzweig, MC, Bjorkman, PJ (2018) Partially-open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion. Cell Host and Microbe 24: 579-592.e4. (*these authors contributed equally to the work) PMCID: PMC6185872 doi:10.1016/j.chom.2018.09.003

55. Barnes, CO, Gristick, HB, Freund, NT, Escolano, A, Lyubimov, AY, Hartweger, H, West Jr, AP, Cohen, AE, Nussenzweig, MC, Bjorkman, PJ (2018) Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope. Nat Commun 9: 1251-1262. PMCID: PMC5871869 doi:10.1038/s41467-018-03632-y

54. Stadtmueller, BM, Bridges, MD, Dam, K-M, Lerch, MT, Huey-Tubman, KE, Hubbell, WL, Bjorkman, PJ (2018) DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions. Immunity Aug 21, 49: 1-12. PMCID: PMC6104740 doi:10.1016/j.immuni.2018.06.017

53. Cohn LB, da Silva IT, Valieris R, Huang AS, Lorenzi JCC, Cohen YZ, Pai JA, Butler AL, Caskey M, Jankovic M, Nussenzweig MC. (2018) Clonal CD4+ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation. Nat Med 24: 604-609. PMCID: PMC5972543 doi:10.1038/s41591-018-0017-7

52. Gautam R, Nishimura Y, Gaughan N, Gazumyan A, Schoofs T, Buckler-White A, Seaman MS, Swihart BJ, Follmann DA, Nussenzweig MC, Martin MA. (2018) A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection. Nat Med 24: 610-616. doi:10.1038/s41591-018-0001-2

2017

51. Bournazos S, Wang TT, Dahan R, Maamary J, Ravetch JV (2017) Signaling by Antibodies: Recent Progress. Annu Rev Immunol 35: 285-311. PMCID: PMC5613280 doi:10.1146/annurev-immunol-051116-052433

50. Bournazos S, Ravetch JV (2017) Anti-retroviral antibody FcγR-mediated effector functions. Immunol Rev 275: 285-295. Review doi:10.1111/imr.12482

49. Gristick, HB, Wang, H, Bjorkman, PJ (2017) X-ray and EM structures of a natively glycosylated HIV-1 envelope trimer. Acta Cryst. D73: 822–828 PMCID: PMC5633907 doi:10.1107/S2059798317013353

48. Mayer, CT, Gazumyan, A, Kara, EE, Gitlin, AD, Golijanin, J, Viant, C, Pai, J, Oliveira, TY, Wang, Q, Escolano, A, Medina-Ramirez, M, Sanders, RW, Nussenzweig, MC (2017) The microanatomic segregation of selection by apoptosis in the germinal center. Science 358 (6360). pii: eaao2602. Epub 2017 Sep 21 doi:10.1126/science.aao2602

47. Bournazos, S, Ravetch, JV (2017) Fcγ Receptor Function and the Design of Vaccination Strategies. Immunity 47: 224-233 PMCID: PMC5573140 doi:10.1016/j.immuni.2017.07.009

46. Horwitz JA, Bar-On Y, Lu CL, Fera D, Lockhart AAK, Lorenzi JCC, Nogueira L, Golijanin J, Scheid JF, Seaman MS, Gazumyan A, Zolla-Pazner S, Nussenzweig MC (2017) Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo. Cell 170: 637-648 PMCID: PMC5554461 doi:10.1016/j.cell.2017.06.048

45. Nishimura Y, Gautam R, Chun TW, Sadjadpour R, Foules KE, Shingai M, Klein F, Gazumyan A, Golijanin J, Donaldson M, Donau OK, Plishka RJ, Buckler-White A, Seaman MS, Lifson JD, Koup RA, Fauci AS, Nussenzweig MC, Martin MA. (2017) Early antibody therapy can induce long-lasting immunity to SHIV. Nature 543: 559-563. PMCID: PMC5458531 doi.10.1038/nature21435

44. Wang, H, Gristick, HB, Scharf, L, West, AP, Jr, Galimidi, RP, Seaman, MS, Freund, NT, Nussenzweig, MC, Bjorkman, PJ (2017) Asymmetric recognition of HIV-1 Env trimer by V1V2 loop-targeting antibodies. eLife 6: e27389. PMCID: PMC5472438 doi:10.7554/eLife.27389

43. Freund, NT, Wang, H, Scharf, L, Nogueira, L, Horwitz, JA, Bar-On, Y, Golijanin, J, Sievers, SA, Sok, D, Cai, H, Cesar Lorenzi, JC, Halper-Stromberg, A, Toth, I, Piechocka-Trocha, A, Gristick, HB, van Gils, MJ, Sanders, RW, Wang, L-X, Seaman, MS, Burton, DR, Gazumyan, A, Walker, BD, West, AP, Bjorkman, PJ, Nussenzweig, MC(2017). "Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller." Sci Transl Med 9: eaal2144 PMCID: PMC5467220 doi:10.1126/scitranslmed.aal2144

42. Caskey, M, Schoofs, T, Gruell, H, Settler, A, Karagounis, T, Kreider EF, Murrell, B, Pfeifer, N, Nogueira, L, Oliveira, TY, Learn, GH, Cohen, YZ, Lehmann, C, Gillor, D, Shimeliovich, I, Unson-O'Brien, C, Weiland, D, Robles, A, Kummerle, T, Wyen, C, Levin, R, Witmer-Pack, M, Eren, K, Ignacio, C, Kiss, S, West, AP Jr, Mouquet, H, Zingman BS, Gulick, RM, Keler, T, Bjorkman PJ, Seaman, MS, Hahn, BH, Fatkenheuer, G, Schlesinger, SJ, Nussenzweig, MC, Klein, F (2017). Antibody 10-1074 suppresses viremia in HIV-1-infected individuals. Nat Med 23: 185-191 PMCID: PMC5467219 doi:10.1038/nm.4268

2016

41. Bournazos S, Wang TT, Ravetch JV. (2016) The Role and Function of Fcγ Receptors on Myeloid Cells. Microbiol Spectr Dec;4(6). PMCID: PMC5240797 doi:10.1128/microbiolspec.MCHD-0045-2016

40. Wang, H, Cohen, AA, Galimidi, RP, Gristick, HB, Jensen, GJ, Bjorkman, PJ (2016). Cryo-EM structure of a CD4-bound open HIV-1 Envelope trimer reveals structural rearrangements of the gp120 V1V2 loop. Proc Natl Acad Sci USA published ahead of print Oct 31.PMCID: PMC5135367 doi:10.1073/pnas.1615939113

39. Gristick, HB, von Boehmer, L, West, AP, Jr, Schamber, M, Gazumyan, A, Golijanin, J, Seaman, MS, Fätkenheuer, G, Klein, F, Nussenzweig, MC, Bjorkman, PJ (2016) Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site. Nature Struct Mol Biol 23:906–915 PMCID: PMC5127623 doi:10.1038/nsmb.3291

38. Steichen JM, Kulp DW, Tokatlian T, Escolano A, Dosenovic P, Stanfield RL, McCoy LE, Ozorowski G, Hu X, Kalyuzhniy O, Briney B, Schiffner T, Garces F, Freund NT, Gitlin AD, Menis S, Georgeson E, Kubitz M, Adachi Y, Jones M, Mutafyan AA, Yun DS, Mayer CT, Ward AB, Burton DR, Wilson IA, Irvine DJ, Nussenzweig MC, Schief WR. HIV Vaccine Design to Target Germline Precursors of Glycan- Dependent Broadly Neutralizing Antibodies. Immunity 45:483-96. PMCID: PMC5040827 doi:10.1016/j.immuni.2016.08.016

37. Escolano A, Steichen JM, Dosenovic P, Kulp DW, Golijanin J, Sok D, Freund NT, Gitlin AD, Oliveira T, Araki T, Lowe S, Chen ST, Heinemann J, Yao KH, Georgeson E, Saye-Francisco KL, Gazumyan A, Adachi Y, Kubitz M, Burton DR, Schief WR, Nussenzweig MC (2016) Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice. Cell 166:1445-1458.e12. PMCID: PMC5019122 doi:10.1016/j.cell.2016.07.030

36. Scheid JF, Horwitz JA, Bar-On Y, Kreider EF, Lu CL, Lorenzi JC, Feldmann A, Braunschweig M, Nogueira L, Oliveira T, Shimeliovich I, Patel R, Burke L, Cohen YZ, Hadrigan S, Settler A, Witmer-Pack M, West AP Jr, Juelg B, Keler T, Hawthorne T, Zingman B, Gulick RM, Pfeifer N, Learn GH, Seaman MS, Bjorkman PJ, Klein F, Schlesinger SJ, Walker BD, Hahn BH, Nussenzweig MC, Caskey M. (2016) HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption. Nature 535: 556-560. PMCID: PMC5034582 doi:10.1038/nature18929.

35. Bournazos S, Gazumyan A, Seaman MS, Nussenzweig MC, Ravetch JV (2016) Bispecific anti-HIV-1 antibodies with enhanced breadth and potency. Cell 16:1609–1620 PMCID: PMC4970321 doi:10.1016/j.cell.2016.04.050.

34. Lu CL, Murakowski DK, Bournazos S, Schoofs T, Sarkar D, Halper-Stromberg A, Horwitz JA, Nogueira L, Golijanin J, Gazumyan A, Ravetch JV, Caskey M, Arup K. Chakraborty AK, Nussenzweig MC (2016) Enhanced clearance of HIV-1-infected cells by anti-HIV-1 broadly neutralizing antibodies in vivo. Science 352:1001-1004. PMCID: PMC 5126967 doi:10.1126/science.aaf1279.

33. Schoofs, T, Klein, F, Braunschweig, M, Kreider, EF, Feldmann, A, Nogueira, L, Oliveira, T, Lorenzi, JC, Parrish, EH, Learn, GH, West, AP, Bjorkman, PJ, Schlesinger, SJ, Seaman, MS, Czartoski, J, McElrath, MJ, Pfeifer, N, Hahn, BH, Caskey, M, & Nussenzweig, MC (2016) HIV-1 Therapy with Monoclonal Antibody 3BNC117 Elicits Host Immune Responses against HIV-1. Science 352:997-1001. PMCID: PMC5151174 doi:10.1126/science.aaf0972.

32. Gautam, R, Nishimura, Y, Pegu, A, Nason, MC, Klein, F, Gazumyan, A, Golijanin, J, Buckler-White, A, Sadjadpour, R, Wang, K, Mankoff, Z, Schmidt, SD, Lifson, J, Mascola, JR, Nussenzweig, MC, Martin MA (2016) A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges. Nature 533:105–109 PMCID: PMC5127204 doi:10.1038/nature17677.

31. Scharf, L, West, AP, Jr, Sievers, SA, Chen, C, Jiang, S, Gao, H, Gray, MD, McGuire, AT, Scheid, JF, Nussenzweig, MC, Stamatatos, L, Bjorkman, PJ (2016) Structural basis for germline antibody recognition of HIV-1 immunogens. eLife 5:e13783. PMCID: PMC4811768 doi:10.7554/eLife.13783

30. McGuire AT, Gray MD, Dosenovic P, Gitlin AD, Freund NT, Petersen J, Correnti C, Johnsen W, Kegel R, Stuart AB, Glenn J, Seaman MS, Schief WR, Strong RK, Nussenzweig MC, Stamatatos L (2016) Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice. Nat Commun 2016 7:10618. PMCID: PMC477007 doi:10.1038/ncomms10618.

29. Ahmed, AA, Keremane, SR, Vielmetter, J, Bjorkman, PJ (2016) Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa. J Struct Biol. 194:78-89. PMCID: PMC4769027 doi:10.1016/j.jsb.2016.02.001

28: Halper-Stromberg A, Nussenzweig MC. (2016) Towards HIV-1 remission: potential roles for broadly neutralizing antibodies. J Clin Invest 2016 126:415-23. Epub 2016 Jan 11. Review. PMCID: PMC4731188 doi:10.1172/JCI80561

27. Davenport, YW, West, AP, Jr., Bjorkman, PJ (2016) Structure of an HIV-2 gp120 in complex with CD4. J Virol 90:2112-2118. PMCID: PMC4733984 doi:10.1128/JVI.02678-15

2015

26. Zolla-Pazner, S, Cohen, SS, Boyd, D, Kong, X-P, Seaman, M Nussenzweig, MC, Klein, F, Overbaugh, J, Totrov, M (2015) Structure/Function studies involving the V3 region of the HIV-1 envelope delineate multiple factors that affect neutralization sensitivity. J Virol 90:636-49. PMCID: PMC4702699 doi:10.1128/JVI.01645-15

25. Freund, NT, Horwitz, JA, Nogueira, L, Sievers, SA, Scharf, L, Scheid, JF, Gazumyan, A, Liu, C, Velinzon, K, Goldenthal, A, Sanders, RW, Moore, JP, Bjorkman, PJ, Seaman, MS, Walker, BD, Klein, F. Nussenzweig, MC (2015) A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo. PLoS Pathog 11:e1005238. PMCID: PMC4627763 doi:10.1371/journal.ppat.1005238

24. Scharf, L, Wang, H, Gao, H, Chen, S, McDowall, AW, Bjorkman, PJ (2015) Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env. Cell 162:1379–13. PMCID: PMC4587768 doi:10.1016/j.cell.2015.08.035

23. Dosenovic, P, von Boehmer, L, Escolano, A, Jardine, J, Freund, NT, Gitlin, AD, McGuire, AT, Kulp, DW, Oliveira, T, Scharf, L, Pietzsch, J, Gray, MD, Cupo, A, van Gils, MJ, Yao, KH, Liu, C, Gazumyan, A, Seaman, MS, Björkman, PJ, Sanders, RW, Moore, JP, Stamatatos, L, Schief, WR, Nussenzweig, MC (2015) Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice. Cell 161:1505-15. PMCID: PMC4604566 doi:10.1016/j.cell.2015.06.003

22. Yoon, H, Macke, J, West, AP Jr, Foley, B, Bjorkman, PJ, Korber, B, Yusim, K (2015) CATNAP: a tool to compile, analyze and tally neutralizing antibody panels.Nucleic Acids Res 43:W213-9. PMCID: PMC4489231 doi:10.1093/nar/gkv404

21. Zhou, T, Lynch, RM, Chen, L, Acharya, P, Wu, X, Doria-Rose, NA, Joyce, MG, Lingwood, D, Soto, C, Bailer, RT, Ernandes, MJ, Kong, R, Longo, NS, Louder, MK, McKee, K, O'Dell, S, Schmidt, SD, Tran, L, Yang, Z, Druz, A, Luongo, TS, Moquin, S, Srivatsan, S, Yang, Y, Zhang, B, Zheng, A, Pancera, M, Kirys, T, Georgiev, IS, Gindin, T, Peng, HP, Yang, AS; NISC Comparative Sequencing Program, Mullikin, JC, Gray, MD, Stamatatos, L, Burton, DR, Koff, WC, Cohen, MS, Haynes, BF, Casazza, JP, Connors, M, Corti, D, Lanzavecchia, A, Sattentau, QJ, Weiss, RA, West, AP Jr., Bjorkman, PJ, Scheid, JF, Nussenzweig, MC, Shapiro, L, Mascola, JR, Kwong, PD (2015) Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell 161:1-13.PMCID: PMC4683157 doi: 10.1016/j.cell.2015.05.007

20. Sievers, SA, Scharf, L, West, AP Jr., Bjorkman, PJ (2015) Antibody engineering for increased potency,breadth and half-life. Curr Opin HIV AIDS 10:151-159. PMCID: PMC4465343 doi:10.1097/COH.0000000000000148

19. Galimidi, RP, Klein, JS, Politzer, MS, Bai, S, Seaman, MS, Nussenzweig, MC, West, AP Jr., Bjorkman, PJ (2015) Intra-Spike Crosslinking Overcomes Antibody Evasion by HIV-1. Cell 160:433-446. PMCID: PMC4401576 doi:10.1016/j.cell.2015.01.016

18. Cohn LB, Silva IT, Oliveira TY, Rosales RA, Parrish EH, Learn GH, Hahn BH,
Czartoski JL, McElrath MJ, Lehmann C, Klein F, Caskey M, Walker BD, Siliciano JD,
Siliciano RF, Jankovic M, Nussenzweig MC. (2015) HIV-1 integration landscape during
latent and active infection. Cell 160:420-32. PMCID: PMC4371550 doi:10.1016/j.cell.2015.01.020

2014

17. Klein, F, Nogueira, L, Nishimura, Y, Phad, G, West, AP Jr., Halper-Stromberg, A, Horwitz, JA, Gazumyan, A, Liu, C, Eisenreich, TR, Lehmann, C, Fätkenheuer, G, Williams, C, Shingai, M, Martin, MA, Bjorkman, PJ, Seaman, MS, Zolla-Pazner, S, Karlsson Hedestam, GB, Nussenzweig, MC (2014) Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants. J Exp Med 211 12:2361-72. PMC4235636 doi:10.1084/jem.20141050

16. Halper-Stromberg A, Lu CL, Klein F, Horwitz JA, Bournazos S, Nogueira L, Eisenreich TR, Liu C, Gazumyan A, Schaefer U, Furze RC, Seaman MS, Prinjha R, Tarakhovsky A, Ravetch JV, Nussenzweig MC (2014) Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice. Cell 2014 158:989-99. PMCID: PMC4163911 doi:10.1016/j.cell.2014.07.043

15. *Klein, JS, *Jiang, S, *Galimidi, RP, Keeffe, JR, Bjorkman, PJ (2014) Design and characterization of structured protein linkers with differing flexibilities Protein Eng Des and Sel 27:325-330. (* these authors contributed equally to the work) PMCID: PMC4191447 doi: 10.1093/protein/gzu043

14. Bournazos S, Klein F, Pietzsch J, Seaman MS, Nussenzweig MC, Ravetch JV (2014) Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity. Cell 158:1243-53. PMCID: PMC4167398 doi:10.1016/j.cell.2014.08.023.

13. Ahmed, AA, Giddens, J, Pincetic, A, Lomino JV, Ravetch, JV, Wang, L-X, Bjorkman, PJ (2014) Structural characterization of anti-inflammatory Immunoglobulin G Fc proteins. J Mol Biol 426:3166-3179. PMCID: PMC4159253 doi: 10.1016/j.jmb.2014.07.006

12. Scharf, L, Scheid, JF, Lee, JH, West, AP, Chen, C, Gao, H, Gnanapragasam, PNP, Mares, R, Seaman, MS, Ward, AB, Nussenzweig, MC, Bjorkman, PJ (2014) Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike. Cell Reports 7:785–795. PMCID: PMC4109818 doi:10.1016/j.celrep.2014.04.001

11. West, AP Jr., Scharf, L, Scheid, JF, Klein, F, Bjorkman PJ Nussenzweig, MC (2014) Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy. Cell 156:633-648. PMCID: PMC4041625 doi:10.1016/j.cell.2014.01.052

2013

10. Barouch, DH, Whitney, JB, Moldt, B, Klein, F, Oliveira, TY, Liu, J, Stephenson, KE, Chang, HW, Shekhar, K, Gupta, S, Nkolola, JP, Seaman, MS, Smith, KM, Borducchi, EN, Cabra,l C, Smith, JY, Blackmore, S, Sanisetty, S, Perry, JR, Beck, M, Lewis, MG, Rinaldi, W, Chakraborty, AK, Poignard, P, Nussenzweig, MC, Burton, DR (2013) Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature 503:224-8. PMCID: PMC4017780 doi:10.1038/nature12744. Epub 2013 Oct 30.

9. Shingai, M, Nishimura, Y, Klein, F, Mouquet, H, Donau, OK, Plishka, R, Buckler-White, A, Seaman, M, Piatak, M Jr, Lifson, JD, Dimitrov, DS, Nussenzweig, MC, Martin, MA (2013) Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature 503:277-80. PMCID: PMC4133787 doi: 10.1038/nature12746. Epub 2013 Oct 30. PubMed PMID: 24172896.

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