Our Research

The Gradinaru Lab uses advanced technologies such as optogenetics, CLARITY, physiology, imaging, and behavior to understand and develop therapies for neurological diseases.

Lecture on Machine Learning Assisted Directed Evolution

NIH Director's Blog highlights recent G-Lab research

Scientific American features our work on Delivery Vectors that Cross the Blood-Brain Barrier

Short talk on Deep Brain Stimulation, Optogenetics, and CLARITY for the Stanford Big Data 2015

Gradinaru/Newman Collaboration Yields 3D View of Bacterial Infection by MiPACT tissue clearing [Video] [Caltech Press Release]

Scientific American 10 World Changing Ideas 2014 features our group's work on Transparent Organisms

CBS News on "Single-cell phenotyping within transparent intact tissue through whole-body clearing. Cell, 2014"

The World Economic Forum Blog: Interview about Optogenetics and CLARITY

Short Version: TEDxCaltech: The Brain, January 2013

Long Version: Watson Richard C. Biedebach Memorial Lecture, December 2012 (Available on iTunes U)

Positions currently available

Please email your CV and a cover page detailing your future research or position type interests to Dr. Viviana Gradinaru (viviana@caltech.edu).

Gradinaru Lab News


Viviana recieves the 2020 Vilcek Prize for Creative Promise in Biomedical Science!


Congratulations to Elliot for being selected as a 2019 Bridge to Independence Award fellow by the Simons Foundation Autism Research Initiative!


Lab members share their research projects as a part of Graduate Student Scientific Storytelling supported by Tianqiao and Chrissy Chen Institute for Neuroscience.

David Brown: Programming Biology with Viruses

Tatyana Dobreva: Engineering Garbage Cases for Neuronal Waste

Xinhong Chen: Engineering a better delivery vehicle for gene therapy

Xiaozhe Ding: Making larger 'shipping boxes' for Genes


Michael and Grigorios' work on Settling the Debate on Serotonin's Role in Sleep is now out in "Neuron". Congratulations!


Viviana is featured in the Neuron "Voices" article Driving the Next Steps with Technology, celebrating 30 years of Neuron, where she discusses recent advances and neuroscience applications of adeno-associated viral vectors.


Rose's AAV protocols paper is featured as the cover of Nature Protocols.


Viviana is promoted to Professor of Neuroscience and Biological Engineering. Congratulations!


Our lab just published a review paper on Viral strategies for targening CNS/PNS.


Congratulations to Jenny who just received NARSAD Young Investigator Grant!


Ken's AAV paper is featured as the cover of Nature Neuroscience.


Viviana, Ryan and Jenny participated in "Advanced Technologies in Molecular Neuroscience" course at the Cold Spring Harbor Lab and taught tissue clearing methods. (Image: PACT clearing of Thy1-eYFP mouse brain)


Ken's paper on novel engineered AAVs is published in Nature Neuroscience.


Ryan's work on DRN dopamine neurons is published in Neuron.


Dr. Ken Chan, GLab's first PhD recipient, won the (1) Demetriades-Tsafka-Kokkalis Prize in Entrepreneurship or Related Fields and the (2) Lawrence L. and Audrey W. Ferguson Prize for his thesis work on viral vectors and tissue clearing. Congratulations!!


Alon and Ken's paper on bone CLARITY is published in Science Translational Medicine.


Discussing neurodegeneration with Bill Gates at Caltech.


Viviana is featured in the Neuron "Voices" article Global Collaboration, Learning from Other Fields.


Viviana receives Peter Gruss Young Investigator Award!


We collaborated with the Newman lab for Microbial Imaging after PACT - "Exposing the 3D biogeography and metabolic states of pathogens in cystic fibrosis sputum via hydrogel embedding, clearing and rRNA labeling". Paper here.


Jenny's review on tissue clearing and viral vectors for mapping biological circuits is now in Current Opinion in Biotechnology.


Cheng's paper out in Neuron!


Viviana is awarded a PECASE!: "Presidential Early Career Awards for Scientists and Engineers, the highest honor bestowed by the United States Government on science and engineering professionals in the early stages of their independent research careers."


Ben's paper out in Nature Biotechnology on Delivering genes across the blood-brain barrier


Nature News and Views on Optogenetic Voltage Sensors


If you use tissue clearing - these detailed protocols just out in Nature Protocols will help!


Spying on Opsins.


Viviana is a Sloan Fellow in Neuroscience.


Glab is awarded a BRAIN initiative grant in collaboration with Changhuei Yang's group at Caltech.


Viviana is elected to the Allen Brain Institute Next Generation Leaders Council.


Nick and Claire's paper on voltage sensing with Archer 1 has been published in Nature Communications.


Glab's first paper has been published in Cell.

Old News Archive

Life in the GLab


G-Lab members participated in Beaver 5k!


Uninspired? On Creative Work.


Picture of the Month!


Lindsay and Jenny performed the first in vivo electrophysiology experiment with optogenetics.


Happy birthday, Claire!