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Projects:

1. Nussenzweig. Obtain new human antibodies that neutralize HIV strains resistant to current bNAbs and produce mouse models to examine how B cells producing bNAbs develop from their progenitors in vivo.

2. Ravetch. Investigate the contributions of Fc effector function to the newly-isolated HIV bNAbs in vitro and in a new in vivo mouse model for HIV entry.

3. Bjorkman. Determine the structural correlates of broad and potent neutralization and improved effector functions.


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Caltech rockefeller univ NIGMS