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46. Gristick, HB, Wang, H, Bjorkman, PJ (2017) X-ray and EM structures of a natively glycosylated HIV-1 envelope trimer. Acta Cryst. D73: 822–828 PMCID: PMC5633907 [Available on 2018-10-01] doi:10.1107/S2059798317013353

45. Nishimura Y, Gautam R, Chun TW, Sadjadpour R, Foules KE, Shingai M, Klein F, Gazumyan A, Golijanin J, Donaldson M, Donau OK, Plishka RJ, Buckler-White A, Seaman MS, Lifson JD, Koup RA, Fauci AS, Nussenzweig MC, Martin MA. (2017) Early antibody therapy can induce long-lasting immunity to SHIV. Nature 543:559-563. PMCID: PMC5458531 doi.10.1038/nature21435

44. Wang, H, Gristick, HB, Scharf, L, West, AP, Jr, Galimidi, RP, Seaman, MS, Freund, NT, Nussenzweig, MC, Bjorkman, PJ (2017) Asymmetric recognition of HIV-1 Env trimer by V1V2 loop-targeting antibodies. eLife 6: e27389. PMCID: PMC5472438 doi:10.7554/eLife.27389

43. Freund, NT, Wang, H, Scharf, L, Nogueira, L, Horwitz, JA, Bar-On, Y, Golijanin, J, Sievers, SA, Sok, D, Cai, H, Cesar Lorenzi, JC, Halper-Stromberg, A, Toth, I, Piechocka-Trocha, A, Gristick, HB, van Gils, MJ, Sanders, RW, Wang, L-X, Seaman, MS, Burton, DR, Gazumyan, A, Walker, BD, West, AP, Bjorkman, PJ, Nussenzweig, MC(2017). "Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller." Sci Transl Med 9: eaal2144 PMCID: PMC5467220 doi:10.1126/scitranslmed.aal2144

42. Caskey, M, Schoofs, T, Gruell, H, Settler, A, Karagounis, T, Kreider EF, Murrell, B, Pfeifer, N, Nogueira, L, Oliveira, TY, Learn, GH, Cohen, YZ, Lehmann, C, Gillor, D, Shimeliovich, I, Unson-O'Brien, C, Weiland, D, Robles, A, Kummerle, T, Wyen, C, Levin, R, Witmer-Pack, M, Eren, K, Ignacio, C, Kiss, S, West, AP Jr, Mouquet, H, Zingman BS, Gulick, RM, Keler, T, Bjorkman PJ, Seaman, MS, Hahn, BH, Fatkenheuer, G, Schlesinger, SJ, Nussenzweig, MC, Klein, F (2017). Antibody 10-1074 suppresses viremia in HIV-1-infected individuals. Nat Med 23: 185-191 PMCID: PMC5467219 doi:10.1038/nm.4268


41. Bournazos S, Wang TT, Ravetch JV. (2016) The Role and Function of Fcγ Receptors on Myeloid Cells. Microbiol Spectr Dec;4(6). PMCID: PMC5240797 doi:10.1128/microbiolspec.MCHD-0045-2016

40. Wang, H, Cohen, AA, Galimidi, RP, Gristick, HB, Jensen, GJ, Bjorkman, PJ (2016). Cryo-EM structure of a CD4-bound open HIV-1 Envelope trimer reveals structural rearrangements of the gp120 V1V2 loop. Proc Natl Acad Sci USA published ahead of print Oct 31.PMCID: PMC5135367 [Available on 2017-05-15] doi:10.1073/pnas.1615939113

39. Gristick, HB, von Boehmer, L, West, AP, Jr, Schamber, M, Gazumyan, A, Golijanin, J, Seaman, MS, Fätkenheuer, G, Klein, F, Nussenzweig, MC, Bjorkman, PJ (2016) Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site. Nature Struct Mol Biol 23:906–915 PMCID: PMC5127623 doi:10.1038/nsmb.3291

38. Steichen JM, Kulp DW, Tokatlian T, Escolano A, Dosenovic P, Stanfield RL, McCoy LE, Ozorowski G, Hu X, Kalyuzhniy O, Briney B, Schiffner T, Garces F, Freund NT, Gitlin AD, Menis S, Georgeson E, Kubitz M, Adachi Y, Jones M, Mutafyan AA, Yun DS, Mayer CT, Ward AB, Burton DR, Wilson IA, Irvine DJ, Nussenzweig MC, Schief WR. HIV Vaccine Design to Target Germline Precursors of Glycan- Dependent Broadly Neutralizing Antibodies. Immunity 45:483-96. PMCID: PMC5040827 doi:10.1016/j.immuni.2016.08.016

37. Escolano A, Steichen JM, Dosenovic P, Kulp DW, Golijanin J, Sok D, Freund NT, Gitlin AD, Oliveira T, Araki T, Lowe S, Chen ST, Heinemann J, Yao KH, Georgeson E, Saye-Francisco KL, Gazumyan A, Adachi Y, Kubitz M, Burton DR, Schief WR, Nussenzweig MC (2016) Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice. Cell 166:1445-1458.e12. PMCID: PMC5019122 [Available on 2017-09-08] doi:10.1016/j.cell.2016.07.030

36. Scheid JF, Horwitz JA, Bar-On Y, Kreider EF, Lu CL, Lorenzi JC, Feldmann A, Braunschweig M, Nogueira L, Oliveira T, Shimeliovich I, Patel R, Burke L, Cohen YZ, Hadrigan S, Settler A, Witmer-Pack M, West AP Jr, Juelg B, Keler T, Hawthorne T, Zingman B, Gulick RM, Pfeifer N, Learn GH, Seaman MS, Bjorkman PJ, Klein F, Schlesinger SJ, Walker BD, Hahn BH, Nussenzweig MC, Caskey M. (2016) HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption. Nature 535: 556-560. PMCID: PMC5034582 doi:10.1038/nature18929.

35. Bournazos S, Gazumyan A, Seaman MS, Nussenzweig MC, Ravetch JV (2016) Bispecific anti-HIV-1 antibodies with enhanced breadth and potency. Cell 16:1609–1620 PMCID: PMC4970321 doi:10.1016/j.cell.2016.04.050.

34. Lu CL, Murakowski DK, Bournazos S, Schoofs T, Sarkar D, Halper-Stromberg A, Horwitz JA, Nogueira L, Golijanin J, Gazumyan A, Ravetch JV, Caskey M, Arup K. Chakraborty AK, Nussenzweig MC (2016) Enhanced clearance of HIV-1-infected cells by anti-HIV-1 broadly neutralizing antibodies in vivo. Science 352:1001-1004. PMCID: PMC 5126967 doi:10.1126/science.aaf1279.

33. Schoofs, T, Klein, F, Braunschweig, M, Kreider, EF, Feldmann, A, Nogueira, L, Oliveira, T, Lorenzi, JC, Parrish, EH, Learn, GH, West, AP, Bjorkman, PJ, Schlesinger, SJ, Seaman, MS, Czartoski, J, McElrath, MJ, Pfeifer, N, Hahn, BH, Caskey, M, & Nussenzweig, MC (2016) HIV-1 Therapy with Monoclonal Antibody 3BNC117 Elicits Host Immune Responses against HIV-1. Science 352:997-1001. PMCID: PMC5151174 doi:10.1126/science.aaf0972.

32. Gautam, R, Nishimura, Y, Pegu, A, Nason, MC, Klein, F, Gazumyan, A, Golijanin, J, Buckler-White, A, Sadjadpour, R, Wang, K, Mankoff, Z, Schmidt, SD, Lifson, J, Mascola, JR, Nussenzweig, MC, Martin MA (2016) A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges. Nature 533:105–109 PMCID: PMC5127204 doi:10.1038/nature17677.

31. Scharf, L, West, AP, Jr, Sievers, SA, Chen, C, Jiang, S, Gao, H, Gray, MD, McGuire, AT, Scheid, JF, Nussenzweig, MC, Stamatatos, L, Bjorkman, PJ (2016) Structural basis for germline antibody recognition of HIV-1 immunogens. eLife 5:e13783. PMCID: PMC4811768 doi:10.7554/eLife.13783

30. McGuire AT, Gray MD, Dosenovic P, Gitlin AD, Freund NT, Petersen J, Correnti C, Johnsen W, Kegel R, Stuart AB, Glenn J, Seaman MS, Schief WR, Strong RK, Nussenzweig MC, Stamatatos L (2016) Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice. Nat Commun 2016 7:10618. PMCID: PMC477007 doi:10.1038/ncomms10618.

29. Ahmed, AA, Keremane, SR, Vielmetter, J, Bjorkman, PJ (2016) Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa. J Struct Biol. 194:78-89. PMCID: PMC4769027 doi:10.1016/j.jsb.2016.02.001

28: Halper-Stromberg A, Nussenzweig MC. (2016) Towards HIV-1 remission: potential roles for broadly neutralizing antibodies. J Clin Invest 2016 126:415-23. Epub 2016 Jan 11. Review. PMCID: PMC4731188 doi:10.1172/JCI80561

27. Davenport, YW, West, AP, Jr., Bjorkman, PJ (2016) Structure of an HIV-2 gp120 in complex with CD4. J Virol 90:2112-2118. PMCID: PMC4733984 doi:10.1128/JVI.02678-15


26. Zolla-Pazner, S, Cohen, SS, Boyd, D, Kong, X-P, Seaman, M Nussenzweig, MC, Klein, F, Overbaugh, J, Totrov, M (2015) Structure/Function studies involving the V3 region of the HIV-1 envelope delineate multiple factors that affect neutralization sensitivity. J Virol 90:636-49. PMCID: PMC4702699 doi:10.1128/JVI.01645-15

25. Freund, NT, Horwitz, JA, Nogueira, L, Sievers, SA, Scharf, L, Scheid, JF, Gazumyan, A, Liu, C, Velinzon, K, Goldenthal, A, Sanders, RW, Moore, JP, Bjorkman, PJ, Seaman, MS, Walker, BD, Klein, F. Nussenzweig, MC (2015) A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo. PLoS Pathog 11:e1005238. PMCID: PMC4627763 doi:10.1371/journal.ppat.1005238

24. Scharf, L, Wang, H, Gao, H, Chen, S, McDowall, AW, Bjorkman, PJ (2015) Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env. Cell 162:1379–13. PMCID: PMC4587768 doi:10.1016/j.cell.2015.08.035

23. Dosenovic, P, von Boehmer, L, Escolano, A, Jardine, J, Freund, NT, Gitlin, AD, McGuire, AT, Kulp, DW, Oliveira, T, Scharf, L, Pietzsch, J, Gray, MD, Cupo, A, van Gils, MJ, Yao, KH, Liu, C, Gazumyan, A, Seaman, MS, Björkman, PJ, Sanders, RW, Moore, JP, Stamatatos, L, Schief, WR, Nussenzweig, MC (2015) Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice. Cell 161:1505-15. PMCID: PMC4604566 doi:10.1016/j.cell.2015.06.003

22. Yoon, H, Macke, J, West, AP Jr, Foley, B, Bjorkman, PJ, Korber, B, Yusim, K (2015) CATNAP: a tool to compile, analyze and tally neutralizing antibody panels.Nucleic Acids Res 43:W213-9. PMCID: PMC4489231 doi:10.1093/nar/gkv404

21. Zhou, T, Lynch, RM, Chen, L, Acharya, P, Wu, X, Doria-Rose, NA, Joyce, MG, Lingwood, D, Soto, C, Bailer, RT, Ernandes, MJ, Kong, R, Longo, NS, Louder, MK, McKee, K, O'Dell, S, Schmidt, SD, Tran, L, Yang, Z, Druz, A, Luongo, TS, Moquin, S, Srivatsan, S, Yang, Y, Zhang, B, Zheng, A, Pancera, M, Kirys, T, Georgiev, IS, Gindin, T, Peng, HP, Yang, AS; NISC Comparative Sequencing Program, Mullikin, JC, Gray, MD, Stamatatos, L, Burton, DR, Koff, WC, Cohen, MS, Haynes, BF, Casazza, JP, Connors, M, Corti, D, Lanzavecchia, A, Sattentau, QJ, Weiss, RA, West, AP Jr., Bjorkman, PJ, Scheid, JF, Nussenzweig, MC, Shapiro, L, Mascola, JR, Kwong, PD (2015) Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell 161:1-13.PMCID: PMC4683157 doi: 10.1016/j.cell.2015.05.007

20. Sievers, SA, Scharf, L, West, AP Jr., Bjorkman, PJ (2015) Antibody engineering for increased potency,breadth and half-life. Curr Opin HIV AIDS 10:151-159. PMCID: PMC4465343 doi:10.1097/COH.0000000000000148

19. Galimidi, RP, Klein, JS, Politzer, MS, Bai, S, Seaman, MS, Nussenzweig, MC, West, AP Jr., Bjorkman, PJ (2015) Intra-Spike Crosslinking Overcomes Antibody Evasion by HIV-1. Cell 160:433-446. PMCID: PMC4401576 doi:10.1016/j.cell.2015.01.016

18. Cohn LB, Silva IT, Oliveira TY, Rosales RA, Parrish EH, Learn GH, Hahn BH,
Czartoski JL, McElrath MJ, Lehmann C, Klein F, Caskey M, Walker BD, Siliciano JD,
Siliciano RF, Jankovic M, Nussenzweig MC. (2015) HIV-1 integration landscape during
latent and active infection. Cell 160:420-32. PMCID: PMC4371550 doi:10.1016/j.cell.2015.01.020


17. Klein, F, Nogueira, L, Nishimura, Y, Phad, G, West, AP Jr., Halper-Stromberg, A, Horwitz, JA, Gazumyan, A, Liu, C, Eisenreich, TR, Lehmann, C, Fätkenheuer, G, Williams, C, Shingai, M, Martin, MA, Bjorkman, PJ, Seaman, MS, Zolla-Pazner, S, Karlsson Hedestam, GB, Nussenzweig, MC (2014) Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants. J Exp Med 211 12:2361-72. PMC4235636 doi:10.1084/jem.20141050

16. Halper-Stromberg A, Lu CL, Klein F, Horwitz JA, Bournazos S, Nogueira L, Eisenreich TR, Liu C, Gazumyan A, Schaefer U, Furze RC, Seaman MS, Prinjha R, Tarakhovsky A, Ravetch JV, Nussenzweig MC (2014) Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice. Cell 2014 158:989-99. PMCID: PMC4163911 doi:10.1016/j.cell.2014.07.043

15. *Klein, JS, *Jiang, S, *Galimidi, RP, Keeffe, JR, Bjorkman, PJ (2014) Design and characterization of structured protein linkers with differing flexibilities Protein Eng Des and Sel 27:325-330. (* these authors contributed equally to the work) PMCID: PMC4191447 doi: 10.1093/protein/gzu043

14. Bournazos S, Klein F, Pietzsch J, Seaman MS, Nussenzweig MC, Ravetch JV (2014) Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity. Cell 158:1243-53. PMCID: PMC4167398 doi:10.1016/j.cell.2014.08.023.

13. Ahmed, AA, Giddens, J, Pincetic, A, Lomino JV, Ravetch, JV, Wang, L-X, Bjorkman, PJ (2014) Structural characterization of anti-inflammatory Immunoglobulin G Fc proteins. J Mol Biol 426:3166-3179. PMCID: PMC4159253 doi: 10.1016/j.jmb.2014.07.006

12. Scharf, L, Scheid, JF, Lee, JH, West, AP, Chen, C, Gao, H, Gnanapragasam, PNP, Mares, R, Seaman, MS, Ward, AB, Nussenzweig, MC, Bjorkman, PJ (2014) Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike. Cell Reports 7:785–795. PMCID: PMC4109818 doi:10.1016/j.celrep.2014.04.001

11. West, AP Jr., Scharf, L, Scheid, JF, Klein, F, Bjorkman PJ Nussenzweig, MC (2014) Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy. Cell 156:633-648. PMCID: PMC4041625 doi:10.1016/j.cell.2014.01.052


10. Barouch, DH, Whitney, JB, Moldt, B, Klein, F, Oliveira, TY, Liu, J, Stephenson, KE, Chang, HW, Shekhar, K, Gupta, S, Nkolola, JP, Seaman, MS, Smith, KM, Borducchi, EN, Cabra,l C, Smith, JY, Blackmore, S, Sanisetty, S, Perry, JR, Beck, M, Lewis, MG, Rinaldi, W, Chakraborty, AK, Poignard, P, Nussenzweig, MC, Burton, DR (2013) Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature 503:224-8. PMCID: PMC4017780 doi:10.1038/nature12744. Epub 2013 Oct 30.

9. Shingai, M, Nishimura, Y, Klein, F, Mouquet, H, Donau, OK, Plishka, R, Buckler-White, A, Seaman, M, Piatak, M Jr, Lifson, JD, Dimitrov, DS, Nussenzweig, MC, Martin, MA (2013) Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature 503:277-80. PMCID: PMC4133787 doi: 10.1038/nature12746. Epub 2013 Oct 30. PubMed PMID: 24172896.

8. Horwitz, JA, Halper-Stromberg, A, Mouquet, H, Gitlin, AD, Tretiakova, A, Eisenreich, TR, Malbec, M, Gravemann, S, Billerbeck, E, Dorner, M, Büning, H, Schwartz, O, Knops, E, Kaiser, R, Seaman, MS, Wilson, JM, Rice, CM, Ploss, A, Bjorkman, PJ, Klein, F, Nussenzweig, MC (2013) HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. Proc Natl Acad Sci USA 110:16538-16543. PMCID: PMC3799352 doi:10.1073/pnas.1315295110.

7. Klein, F, Mouquet, H, Dosenovic, P, Scheid, JF, Scharf, L, Nussenzweig, MC (2013) Antibodies in HIV-1 vaccine development and therapy. Science. 341:1199-204. doi: 10.1126/science.1241144.

6. Chuang, GY, Acharya, P, Schmidt, SD, Yang, Y, Louder, MK, Zhou, T, Kwon, YD, Pancera, M, Bailer, RT, Doria-Rose, NA, Nussenzweig, MC, Mascola, JR, Kwong, PD, Georgiev, IS (2013) Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains. J Virol 87(18):10047-58. PMCID: PMC3753990 doi:10.1128/JVI.00984-13. Epub 2013 Jul 10.

5. Gruell, H, Bournazos, S, Ravetch, JV, Ploss, A, Nussenzweig, MC, Pietzsch, J (2013) Antibody and Antiretroviral Preexposure Prophylaxis Prevent Cervicovaginal HIV-1 Infection in a Transgenic Mouse Model. J Virol 87:8535-44. PMCID: PMC3719827 doi:10.1128/JVI.00868-13. Epub 2013 May 29.

4. West, AP Jr, Scharf, L, Horwitz, J, Klein, F, Nussenzweig, MC, Bjorkman PJ (2013) Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues. Proc Natl Acad Sci USA, 110:10598-10603. PMCID: PMC3696754 doi:10.1073/pnas.1309215110

3. Diskin, R, Klein, F, Horwitz, J, Halper-Stromberg, A, Sather, DN, Marcovecchio, PM, Lee, T, West, AP, Gao, H, Seaman, MS, Stamatatos, L, Nussenzweig, MC, Bjorkman, PJ (2013) Restricting HIV-1 Pathways for Escape using Rationally-Designed Anti-HIV-1 Antibodies. J. Exp. Med. 210:1235-49. PMCID: PMC3674693 doi:10.1084/jem.20130221. Epub 2013 May 27.

2. Klein, F, Diskin, R, Scheid, JF, Gaebler, C, Mouquet, H, Fu, BZ; Gnanapragasam, PNP, Seaman, MS, Bjorkman, PJ, Nussenzweig, MC (2013) Somatic mutations of the immunoglobulin framework are essential for broad and potent HIV neutralizing activity. Cell 153:126-38. PMCID: PMC3792590 doi:10.1016/j.cell.2013.03.018

1. Scharf, L, West, AP, Gao, H, Lee, T, Scheid, JF, Nussenzweig, MC, Bjorkman, PJ, Diskin, R (2013) Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody. Proc Natl Acad Sci USA, 110: 6049–54. PMCID: PMC3625305 doi:10.1073/pnas.1303682110


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